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Condensed Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Product revenue, net $ 25,307 $ 15,558
Licensing revenue 236 375
Total revenue, net 25,543 15,933
Less: Cost of goods sold 6,896 5,627
Gross margin 18,647 10,306
Operating expenses:    
Selling, general and administrative 28,020 24,741
Research and development 13,730 12,614
Total operating expenses 41,750 37,355
Operating loss (23,103) (27,049)
(Loss) gain on change in fair value of derivative liabilities (1,250) 464
Interest expense, net (5,586) (4,885)
Other expense, net (121) (128)
Loss from operations before taxes (30,060) (31,598)
Benefit from income taxes 289 472
Net loss (29,771) (31,126)
Preferred stock purchase option   (868)
Net loss applicable to common shareholders $ (29,771) $ (31,994)
Loss per share:    
Basic $ (0.16) $ (0.18)
Diluted $ (0.16) $ (0.18)
Weighted average shares:    
Basic 184,052 175,582
Diluted 184,052 175,582