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Co-Promotion Agreement - Additional Information (Detail) $ in Thousands | 6 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2016 USD ($) Employee | Dec. 31, 2016 | Dec. 31, 2015 USD ($)
Co-Promotion Agreement [Line Items] |  |  |
Accrued expenses and other current liabilities | $ 31,052 |  | $ 24,226
Co-Promotion Agreement (the Agreement) |  |  |
Co-Promotion Agreement [Line Items] |  |  |
Promotion fee as a percentage of gross margin |  |  | 15.00%
Promotion fee as a percentage gross margin | Scheduled to increase to low twenty percent levels in 2017 and 2018, subject to certain adjustments. |  |
Co-Promotion Agreement (the Agreement) | Scenario, Forecast |  |  |
Co-Promotion Agreement [Line Items] |  |  |
Promotion fee as a percentage of gross margin |  | 19.00% |
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America |  |  |
Co-Promotion Agreement [Line Items] |  |  |
Accrued expenses and other current liabilities | $ 2,700 |  | $ 2,500
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum |  |  |
Co-Promotion Agreement [Line Items] |  |  |
Number of sales representatives | Employee | 250 |  |

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- Definition Co-Promotion Agreement [Line Items] + References No definition available. + Details
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