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Nature of Business and Basis of Presentation - Additional Information (Detail) Patient in Thousands, $ in Thousands | 1 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Mar. 31, 2016 Patient | May 31, 2014 | Jan. 31, 2012 | Jun. 30, 2016 USD ($) Segment Employee | Dec. 31, 2015 USD ($) | Jun. 30, 2015 USD ($) | Dec. 31, 2014 USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of operating segments | Segment |  |  |  | 1 |  |  |
REDUCE-IT study, number of patients enrolled | Patient | 8 |  |  |  |  |  |
Cash and cash equivalents |  |  |  | $ 72,491 | $ 106,961 | $ 136,050 | $ 119,539
Total current assets |  |  |  | $ 116,512 | 143,524 |  |
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of sales professionals | Employee |  |  |  | 150 |  |  |
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of sales representatives | Employee |  |  |  | 250 |  |  |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, earliest redemption date |  |  |  | Jan. 19, 2017 |  |  |
Convertible senior notes, repurchase price at option of the issuer |  |  | 100.00% |  |  |  |
Convertible notes, carrying amount net of unamortized discount |  |  |  | $ 15,100 | 15,100 |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, earliest redemption date |  |  |  | Jan. 19, 2019 |  |  |
Convertible senior notes, repurchase price at option of the issuer |  | 100.00% |  |  |  |  |
Convertible notes, carrying amount net of unamortized discount |  |  |  | $ 98,000 | 94,600 |  |
Convertible Debt | 2015 Notes |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, earliest redemption date |  |  |  | Jan. 19, 2019 |  |  |
Convertible notes, carrying amount net of unamortized discount |  |  |  | $ 27,600 | $ 27,000 |  |
Convertible Debt | Date One |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, latest redemption date |  |  |  | Jan. 19, 2017 |  |  |
Convertible Debt | Date Two |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, latest redemption date |  |  |  | Jan. 19, 2022 |  |  |
Convertible Debt | Date Three |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, latest redemption date |  |  |  | Jan. 19, 2027 |  |  |

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