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Nature of Business and Basis of Presentation - Additional Information (Detail)
Patient in Thousands, $ in Thousands
1 Months Ended 6 Months Ended
Mar. 31, 2016
Patient
May 31, 2014
Jan. 31, 2012
Jun. 30, 2016
USD ($)
Segment
Employee
Dec. 31, 2015
USD ($)
Jun. 30, 2015
USD ($)
Dec. 31, 2014
USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Number of operating segments | Segment       1      
REDUCE-IT study, number of patients enrolled | Patient 8            
Cash and cash equivalents       $ 72,491 $ 106,961 $ 136,050 $ 119,539
Total current assets       $ 116,512 143,524    
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Number of sales professionals | Employee       150      
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Number of sales representatives | Employee       250      
Convertible Debt | 2012 Notes              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, earliest redemption date       Jan. 19, 2017      
Convertible senior notes, repurchase price at option of the issuer     100.00%        
Convertible notes, carrying amount net of unamortized discount       $ 15,100 15,100    
Convertible Debt | 2014 Notes              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, earliest redemption date       Jan. 19, 2019      
Convertible senior notes, repurchase price at option of the issuer   100.00%          
Convertible notes, carrying amount net of unamortized discount       $ 98,000 94,600    
Convertible Debt | 2015 Notes              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, earliest redemption date       Jan. 19, 2019      
Convertible notes, carrying amount net of unamortized discount       $ 27,600 $ 27,000    
Convertible Debt | Date One              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, latest redemption date       Jan. 19, 2017      
Convertible Debt | Date Two              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, latest redemption date       Jan. 19, 2022      
Convertible Debt | Date Three              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, latest redemption date       Jan. 19, 2027