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Debt - Additional Information (Detail)
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Dec. 06, 2012
USD ($)
Nov. 30, 2015
USD ($)
shares
$ / shares
May 31, 2014
USD ($)
shares
d
$ / shares
Jan. 31, 2012
USD ($)
shares
$ / shares
Jun. 30, 2016
USD ($)
Dec. 31, 2015
USD ($)
Jun. 30, 2015
USD ($)
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Dec. 31, 2015
USD ($)
Debt Disclosure [Line Items]                    
Gain (loss) on change in fair value of derivative liability         $ 5,810,000   $ (600,000) $ 4,560,000 $ (136,000)  
Carrying amount of debt conversion option over the liability component         11,500,000 $ 11,500,000   11,500,000   $ 11,500,000
Current portion of long-term debt         30,816,000 14,742,000   30,816,000   14,742,000
Other long-term assets         174,000 174,000   174,000   174,000
Exchangeable senior notes, net of discount         125,644,000 136,734,000   125,644,000   136,734,000
Interest payment on notes               7,668,000 5,829,000  
2012 Notes                    
Debt Disclosure [Line Items]                    
Current portion of long-term debt         15,100,000     15,100,000    
Accounting Standards Update 2015-03 | 2014 Notes                    
Debt Disclosure [Line Items]                    
Exchangeable senior notes, net of discount           1,800,000       1,800,000
Accounting Standards Update 2015-03 | 2015 Notes                    
Debt Disclosure [Line Items]                    
Exchangeable senior notes, net of discount           100,000       100,000
Convertible Debt                    
Debt Disclosure [Line Items]                    
Interest expense, contractual coupon interest               2,300,000 2,600,000  
Convertible notes, interest expense               5,700,000 5,600,000  
Accrued interest on convertible note         2,700,000 2,300,000   2,700,000   2,300,000
Convertible Debt | Finance                    
Debt Disclosure [Line Items]                    
Interest payment on notes               2,500,000 2,600,000  
Convertible Debt | 2012 Notes                    
Debt Disclosure [Line Items]                    
Convertible notes, carrying amount net of unamortized discount         15,100,000 15,100,000   15,100,000   15,100,000
Convertible senior notes, principal amount   $ 15,100,000 $ 31,300,000 $ 150,000,000            
Convertible senior notes, stated interest rate       3.50%            
Convertible senior notes, due date       2032            
Proceeds from issuance of convertible debt, net of transaction costs       $ 144,300,000            
Convertible senior notes, payment start date       Jul. 15, 2012            
Convertible senior notes, maturity date       Jan. 15, 2032            
Value of shares in excess of principal amount of Notes based on closing price         11,400,000     11,400,000    
Additional interest rate on notes per annum       0.50%            
Convertible senior notes, repurchase price at option of the issuer       100.00%            
Carrying amount of debt conversion option over the liability component       $ 23,800,000            
Convertible senior notes, fair value         14,686,000 13,637,000   14,686,000   13,637,000
Note, estimated remaining life       24 months            
Convertible senior notes, discount         0 0   0   0
Gain on extinguishment of debt           1,300,000        
Convertible senior notes, repayment   15,900,000                
Convertible senior notes, principal amount purchase   16,200,000                
Convertible Debt | 2012 Notes | American Depository Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes       113.4752            
Convertible senior notes, total ADS into which the debt is exchangeable | shares       1,714,270            
Convertible senior notes, initial exchange price | $ / shares       $ 8.8125            
Convertible Debt | 2012 Notes | Exchanged Debt                    
Debt Disclosure [Line Items]                    
Convertible senior notes, principal amount     118,700,000              
Convertible Debt | 2014 Notes                    
Debt Disclosure [Line Items]                    
Fair value of embedded derivative liability         600,000 2,100,000   600,000   2,100,000
Gain (loss) on change in fair value of derivative liability               1,500,000 1,500,000 1,500,000
Convertible notes, carrying amount net of unamortized discount         98,000,000 94,600,000   98,000,000   94,600,000
Convertible senior notes, principal amount     $ 118,700,000              
Convertible senior notes, stated interest rate     3.50%              
Convertible senior notes, due date     2032              
Convertible senior notes, payment start date     Jul. 15, 2014              
Convertible senior notes, maturity date     Jan. 15, 2032              
Value of shares in excess of principal amount of Notes based on closing price         20,100,000     20,100,000    
Convertible senior notes, repurchase price at option of the issuer     100.00%              
Convertible senior notes, fair value     $ 90,800,000   122,959,000 108,034,000   122,959,000   108,034,000
Convertible senior notes redemption, end date     Jan. 15, 2032              
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days | d     30              
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes     $ 10,100,000              
Convertible senior notes, discount     27,900,000              
Offering costs     2,500,000              
Gain on extinguishment of debt     38,000,000              
Derivative liability at fair value     $ 3,500,000              
Convertible Debt | 2014 Notes | American Depository Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes     384.6154              
Convertible senior notes, total ADS into which the debt is exchangeable | shares     45,666,925              
Convertible senior notes, initial exchange price | $ / shares     $ 2.60              
Convertible Debt | 2014 Notes | Minimum                    
Debt Disclosure [Line Items]                    
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price     110.00%              
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days     20 days              
Convertible Debt | 2015 Notes                    
Debt Disclosure [Line Items]                    
Fair value of embedded derivative liability         200,000 600,000   200,000   600,000
Gain (loss) on change in fair value of derivative liability               400,000   400,000
Convertible notes, carrying amount net of unamortized discount         27,600,000 27,000,000   27,600,000   27,000,000
Interest expense, contractual coupon interest               600,000    
Convertible notes, interest expense               1,200,000    
Convertible senior notes, principal amount   $ 31,300,000                
Convertible senior notes, stated interest rate   3.50%                
Convertible senior notes, due date   2032                
Proceeds from issuance of convertible debt, net of transaction costs   $ 27,500,000                
Convertible senior notes, payment start date   Jan. 15, 2016                
Convertible senior notes, maturity date   Jan. 15, 2032                
Value of shares in excess of principal amount of Notes based on closing price         5,300,000     5,300,000    
Convertible senior notes, fair value   $ 27,500,000     32,378,000 28,448,000   32,378,000   28,448,000
Convertible senior notes, discount   3,800,000                
Offering costs   100,000                
Derivative liability at fair value   $ 500,000                
Convertible Debt | 2015 Notes | American Depository Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes   384.6154                
Convertible senior notes, total ADS into which the debt is exchangeable | shares   12,025,385                
Convertible senior notes, initial exchange price | $ / shares   $ 2.60                
Convertible Debt | 2015 Notes | Minimum                    
Debt Disclosure [Line Items]                    
Beneficial ownership limitation   4.99%                
Convertible Debt | 2015 Notes | Maximum                    
Debt Disclosure [Line Items]                    
Beneficial ownership limitation   19.90%                
Convertible Debt | Other debt outstanding | 2012 Notes                    
Debt Disclosure [Line Items]                    
Convertible senior notes, fair value       $ 126,200,000            
Convertible Debt | Non Cash                    
Debt Disclosure [Line Items]                    
Convertible notes, interest expense               3,400,000 3,000,000  
Convertible Debt | Non Cash | 2014 Notes                    
Debt Disclosure [Line Items]                    
Convertible senior notes, discount         20,700,000 24,100,000   20,700,000   24,100,000
Convertible Debt | Non Cash | 2015 Notes                    
Debt Disclosure [Line Items]                    
Convertible notes, interest expense               600,000    
Convertible senior notes, discount         3,600,000 4,200,000   3,600,000   4,200,000
Convertible Debt | Accounting Standards Update 2015-03 | 2014 Notes                    
Debt Disclosure [Line Items]                    
Other long-term assets           (1,800,000)       (1,800,000)
Convertible Debt | Accounting Standards Update 2015-03 | 2015 Notes                    
Debt Disclosure [Line Items]                    
Other long-term assets           (100,000)       (100,000)
BioPharma Debt                    
Debt Disclosure [Line Items]                    
Amount received at the closing of the agreement $ 100,000,000                  
Maximum repayment of future revenue and receivables 150,000,000       132,100,000     132,100,000    
Repayment under agreement         2,500,000     5,200,000    
Fair value of embedded derivative liability $ 14,600,000                  
Gain (loss) on change in fair value of derivative liability               2,700,000 (800,000)  
Convertible notes, carrying amount net of unamortized discount         92,500,000 $ 91,500,000   92,500,000   $ 91,500,000
BioPharma Debt | Cash                    
Debt Disclosure [Line Items]                    
Interest expense, contractual coupon interest               3,400,000 3,200,000  
BioPharma Debt | Non Cash                    
Debt Disclosure [Line Items]                    
Convertible notes, interest expense               1,000,000 $ 900,000  
BioPharma Debt | August 2016                    
Debt Disclosure [Line Items]                    
Future minimum repayment under agreement         3,300,000     3,300,000    
BioPharma Debt | Fourth quarter of 2016 and first quarter of 2017                    
Debt Disclosure [Line Items]                    
Future minimum repayment under agreement         15,000,000     15,000,000    
BioPharma Debt | May 2017                    
Debt Disclosure [Line Items]                    
Future minimum repayment under agreement         $ 13,000,000     $ 13,000,000