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Nature of Business and Basis of Presentation - Additional Information (Detail) $ in Thousands | 1 Months Ended | 9 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | ---
May 31, 2014 USD ($) | Jan. 31, 2012 USD ($) | Sep. 30, 2016 USD ($) Segment Patient Employee shares | Dec. 31, 2015 USD ($) | Nov. 30, 2015 USD ($) | Sep. 30, 2015 USD ($) | Dec. 31, 2014 USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of operating segments | Segment |  |  | 1 |  |  |  |
REDUCE-IT study, number of patients enrolled and randomized | Patient |  |  | 8,175 |  |  |  |
Cash and cash equivalents |  |  | $ 117,562 | $ 106,961 |  | $ 118,976 | $ 119,539
Total current assets |  |  | 161,180 | 143,524 |  |  |
Proceeds from issuance of common stock, net of transaction costs |  |  | 64,614 |  |  |  |
American Depositary Shares |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of transaction costs |  |  | $ 64,614 |  |  |  |
Issuance of common stock, net of transaction costs (shares) | shares |  |  | 24,265,000 |  |  |  |
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of sales professionals | Employee |  |  | 150 |  |  |  |
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Number of sales representatives | Employee |  |  | 250 |  |  |  |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, earliest redemption date |  | Jan. 19, 2017 |  |  |  |  |
Convertible senior notes, put dates |  |  | May be put back to the Company by the holders on each of January 19, 2017, 2022 and 2027 for cash |  |  |  |
Convertible senior notes, repurchase price at option of the issuer |  | 100.00% |  |  |  |  |
Convertible notes, carrying amount net of unamortized discount |  |  | $ 15,100 | 15,100 |  |  |
Convertible senior notes, principal amount | $ 31,300 | $ 150,000 |  |  | $ 15,100 |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, repurchase price at option of the issuer | 100.00% |  |  |  |  |  |
Convertible notes, carrying amount net of unamortized discount |  |  | 0 | 94,600 |  |  |
Convertible senior notes, principal amount | $ 118,700 |  | 118,700 |  |  |  |
Convertible Debt | 2015 Notes |  |  |  |  |  |  |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] |  |  |  |  |  |  |
Convertible notes, carrying amount net of unamortized discount |  |  | 0 | $ 27,000 |  |  |
Convertible senior notes, principal amount |  |  | $ 31,300 |  |  |  |

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