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Debt - Additional Information (Detail) |  | 1 Months Ended | 3 Months Ended | 9 Months Ended
--- | --- | --- | --- | ---
Dec. 06, 2012 USD ($) | Sep. 30, 2016 USD ($) | Nov. 30, 2015 USD ($) shares $ / shares | May 31, 2014 USD ($) shares d $ / shares | Jan. 31, 2012 USD ($) shares $ / shares | Sep. 30, 2016 USD ($) shares | Dec. 31, 2015 USD ($) | Sep. 30, 2015 USD ($) | Sep. 30, 2016 USD ($) shares | Sep. 30, 2015 USD ($)
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  |  | $ 3,610,000 |  | $ (230,000) | $ 8,170,000 | $ (366,000)
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount |  | $ 93,055,000 |  |  |  | 93,055,000 | $ 91,512,000 |  | 93,055,000 |
Current portion of exchangeable senior notes, net of discount |  | 15,273,000 |  |  |  | 15,273,000 | 2,266,000 |  | 15,273,000 |
Carrying amount of debt conversion option |  | 11,500,000 |  |  |  | 11,500,000 | 11,500,000 |  | 11,500,000 |
Interest payment on notes |  |  |  |  |  |  |  |  | 13,839,000 | 10,225,000
Convertible senior notes, principal amount |  |  |  |  |  |  |  |  | 128,115,000 |
Exchangeable senior notes, net of discount |  |  |  |  |  |  | 136,734,000 |  |  |
Other long-term assets |  | 682,000 |  |  |  | 682,000 | 174,000 |  | 682,000 |
Convertible senior notes, carrying value, exchanged |  | 127,300,000 |  |  |  | 127,300,000 |  |  | 127,300,000 |
Carrying amount of debt conversion option |  |  |  |  |  |  |  |  | 127,437,000 |
Transaction costs |  |  |  |  |  |  |  |  | $ 678,000 |
Common Stock |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares |  |  |  |  |  |  |  |  | 60,311,188 |
Carrying amount of debt conversion option |  |  |  |  |  |  |  |  | $ 40,062,000 |
Accounting Standards Update 2015-03 | 2014 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Exchangeable senior notes, net of discount |  |  |  |  |  |  | 1,800,000 |  |  |
Accounting Standards Update 2015-03 | 2015 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Exchangeable senior notes, net of discount |  |  |  |  |  |  | 100,000 |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, principal amount |  |  |  |  |  |  |  |  | $ 150,000,000 |
Convertible Debt | American Depositary Shares |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares |  |  |  |  |  |  |  |  | 60,311,188 |
Transaction costs |  |  |  |  |  |  |  |  | $ 700,000 |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Interest expense, contractual coupon interest |  |  |  |  |  |  |  |  | 400,000 | 800,000
Convertible senior notes, principal amount |  |  | $ 15,100,000 | $ 31,300,000 | $ 150,000,000 |  |  |  |  |
Convertible senior notes, stated interest rate |  |  |  |  | 3.50% |  |  |  |  |
Current portion of exchangeable senior notes, net of discount |  | 15,100,000 |  |  |  | 15,100,000 |  |  | 15,100,000 |
Convertible senior notes, due date |  |  |  |  | 2032 |  |  |  |  |
Proceeds from issuance of convertible debt, net of transaction costs |  |  |  |  | $ 144,300,000 |  |  |  |  |
Convertible senior notes, payment start date |  |  |  |  | Jul. 15, 2012 |  |  |  |  |
Convertible senior notes, maturity date |  |  |  |  | Jan. 15, 2032 |  |  |  |  |
Value of shares in excess of principal amount of Notes based on closing price |  | 9,600,000 |  |  |  | 9,600,000 |  |  | 9,600,000 |
Additional interest rate on notes per annum |  |  |  |  | 0.50% |  |  |  |  |
Convertible senior notes, repurchase price at option of the issuer |  |  |  |  | 100.00% |  |  |  |  |
Carrying amount of debt conversion option |  |  |  |  | $ 23,800,000 |  |  |  |  |
Convertible senior notes, fair value |  | 15,084,000 |  |  |  | 15,084,000 | 13,637,000 |  | 15,084,000 |
Note, estimated remaining life |  |  |  |  | 24 months |  |  |  |  |
Convertible notes, carrying amount net of unamortized discount |  | 15,100,000 |  |  |  | 15,100,000 | 15,100,000 |  | 15,100,000 |
Accrued interest on convertible note |  | 200,000 |  |  |  | 200,000 | 300,000 |  | 200,000 |
Convertible senior notes, discount |  | 0 |  |  |  | 0 | 0 |  | 0 |
Gain on extinguishment of debt |  |  |  |  |  |  | 1,300,000 |  |  |
Convertible senior notes, repayment |  |  | 15,900,000 |  |  |  |  |  |  |
Convertible senior notes, principal amount purchase |  |  | $ 16,200,000 |  |  |  |  |  |  |
Convertible Debt | 2012 Notes | Finance |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Interest payment on notes |  |  |  |  |  |  |  |  | 500,000 | 1,100,000
Convertible Debt | 2012 Notes | American Depositary Shares |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  |  | 113.4752 |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  |  |  |  | 1,714,270 |  |  |  |  |
Convertible senior notes, initial exchange price | $ / shares |  |  |  |  | $ 8.8125 |  |  |  |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Fair value of embedded derivative liability |  |  |  |  |  |  | 2,100,000 |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  |  |  |  |  | 2,100,000 | 800,000
Interest expense, contractual coupon interest |  |  |  |  |  |  |  |  | 2,900,000 | 3,100,000
Convertible notes, interest expense |  |  |  |  |  |  |  |  | 7,700,000 | 7,700,000
Convertible senior notes, principal amount |  | 118,700,000 |  | $ 118,700,000 |  | 118,700,000 |  |  | 118,700,000 |
Convertible senior notes, stated interest rate |  |  |  | 3.50% |  |  |  |  |  |
Convertible senior notes, due date |  |  |  | 2032 |  |  |  |  |  |
Convertible senior notes, payment start date |  |  |  | Jul. 15, 2014 |  |  |  |  |  |
Convertible senior notes, maturity date |  |  |  | Jan. 15, 2032 |  |  |  |  |  |
Convertible senior notes, repurchase price at option of the issuer |  |  |  | 100.00% |  |  |  |  |  |
Convertible senior notes, fair value |  |  |  | $ 90,800,000 |  |  | 108,034,000 |  |  |
Convertible notes, carrying amount net of unamortized discount |  | 0 |  |  |  | 0 | 94,600,000 |  | 0 |
Accrued interest on convertible note |  | 0 |  |  |  | 0 | 1,900,000 |  | 0 |
Convertible senior notes, principal amount |  | 118,700,000 |  | $ 118,700,000 |  | 118,700,000 |  |  |  |
Exchangeable senior notes, net of discount |  | 0 |  |  |  | $ 0 |  |  | 0 |
Convertible senior notes redemption, end date |  |  |  | Jan. 15, 2032 |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days | d |  |  |  | 30 |  |  |  |  |  |
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes |  |  |  | $ 10,100,000 |  |  |  |  |  |
Convertible senior notes, discount |  |  |  | 27,900,000 |  |  |  |  |  |
Offering costs |  |  |  | 2,500,000 |  |  |  |  |  |
Gain on extinguishment of debt |  |  |  | 38,000,000 |  |  |  |  |  |
Derivative liability at fair value |  |  |  | $ 3,500,000 |  |  |  |  |  |
Convertible Debt | 2014 Notes | Non Cash |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible notes, interest expense |  |  |  |  |  |  |  |  | 4,800,000 | 4,600,000
Convertible senior notes, discount |  |  |  |  |  |  | 24,100,000 |  |  |
Convertible Debt | 2014 Notes | Finance |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Interest payment on notes |  |  |  |  |  |  |  |  | 4,200,000 | 4,200,000
Convertible Debt | 2014 Notes | American Depositary Shares |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  | 384.6154 |  |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  |  |  | 45,666,925 |  |  |  |  |  |
Convertible senior notes, initial exchange price | $ / shares |  |  |  | $ 2.60 |  |  |  |  |  |
Convertible Debt | 2014 Notes | Final As-Adjusted | American Depositary Shares |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  |  |  | 402.0746 |  |  |  |
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares |  |  |  |  |  | 47,739,925 |  |  |  |
Convertible Debt | 2015 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Fair value of embedded derivative liability |  |  |  |  |  |  | 600,000 |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  |  |  |  |  | 600,000 |
Interest expense, contractual coupon interest |  |  |  |  |  |  |  |  | 800,000 |
Convertible notes, interest expense |  |  |  |  |  |  |  |  | 1,700,000 |
Convertible senior notes, principal amount |  | 31,300,000 |  |  |  | $ 31,300,000 |  |  | 31,300,000 |
Convertible senior notes, stated interest rate |  |  | 3.50% |  |  |  |  |  |  |
Convertible senior notes, due date |  |  | 2032 |  |  |  |  |  |  |
Proceeds from issuance of convertible debt, net of transaction costs |  |  | $ 27,500,000 |  |  |  |  |  |  |
Convertible senior notes, fair value |  |  | 27,500,000 |  |  |  | 28,448,000 |  |  |
Convertible notes, carrying amount net of unamortized discount |  | 0 |  |  |  | 0 | 27,000,000 |  | 0 |
Accrued interest on convertible note |  | 0 |  |  |  | 0 | 100,000 |  | 0 |
Convertible senior notes, principal amount |  |  | 31,300,000 |  |  | 31,300,000 |  |  |  |
Exchangeable senior notes, net of discount |  | 0 |  |  |  | $ 0 |  |  | 0 |
Convertible senior notes, discount |  |  | 3,800,000 |  |  |  |  |  |  |
Offering costs |  |  | 100,000 |  |  |  |  |  |  |
Derivative liability at fair value |  |  | $ 500,000 |  |  |  |  |  |  |
Equity component of convertible notes issuance cost |  |  |  |  |  |  |  |  | 87,400,000 |
Debt instrument increase accrued interest |  |  |  |  |  |  |  |  | 800,000 |
Convertible Debt | 2015 Notes | Non Cash |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible notes, interest expense |  |  |  |  |  |  |  |  | 900,000 |
Convertible senior notes, discount |  |  |  |  |  |  | 4,200,000 |  |  |
Convertible Debt | 2015 Notes | Finance |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Interest payment on notes |  |  |  |  |  |  |  |  | 700,000 |
Convertible Debt | 2015 Notes | American Depositary Shares |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  | 384.6154 |  |  |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  |  | 12,025,385 |  |  |  |  |  |  |
Convertible senior notes, initial exchange price | $ / shares |  |  | $ 2.60 |  |  |  |  |  |  |
Convertible Debt | 2015 Notes | Final As-Adjusted | American Depositary Shares |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  |  |  | 402.0746 |  |  |  |
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares |  |  |  |  |  | 12,571,263 |  |  |  |
Convertible Debt | Other debt outstanding | 2012 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, fair value |  |  |  |  | $ 126,200,000 |  |  |  |  |
Convertible Debt | Minimum | 2014 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price |  |  |  | 110.00% |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days |  |  |  | 20 days |  |  |  |  |  |
Convertible Debt | Common Stock |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Carrying amount of debt conversion option |  |  |  |  |  |  |  |  | 40,100,000 |
Convertible Debt | Accounting Standards Update 2015-03 | 2014 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Other long-term assets |  |  |  |  |  |  | (1,800,000) |  |  |
Convertible Debt | Accounting Standards Update 2015-03 | 2015 Notes |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Other long-term assets |  |  |  |  |  |  | (100,000) |  |  |
BioPharma Debt |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Amount received at the closing of the agreement | $ 100,000,000 |  |  |  |  |  |  |  |  |
Maximum repayment of future revenue and receivables | 150,000,000 | 128,800,000 |  |  |  | $ 128,800,000 |  |  | 128,800,000 |
Repayment under agreement |  |  |  |  |  | 3,300,000 |  |  | 8,500,000 |
Fair value of embedded derivative liability | $ 14,600,000 |  |  |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  |  |  |  |  | 5,500,000 | (300,000)
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount |  | 93,100,000 |  |  |  | 93,100,000 | $ 91,500,000 |  | 93,100,000 |
BioPharma Debt | Cash |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Interest expense, contractual coupon interest |  |  |  |  |  |  |  |  | 5,000,000 | 4,900,000
BioPharma Debt | Non Cash |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible notes, interest expense |  |  |  |  |  |  |  |  | 1,500,000 | $ 1,400,000
BioPharma Debt | November 2016 |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement |  | 3,200,000 |  |  |  | 3,200,000 |  |  | 3,200,000 |
BioPharma Debt | First quarter of 2017 |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement |  | 15,000,000 |  |  |  | 15,000,000 |  |  | 15,000,000 |
BioPharma Debt | May 2017 |  |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement |  | $ 13,000,000 |  |  |  | $ 13,000,000 |  |  | $ 13,000,000 |

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- Definition The amount of the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 + Details
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- Definition Number of shares issued during the period as a result of the conversion of convertible securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.29-30) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21475-112644 + Details
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