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Significant Accounting Policies - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |  |  |  |  |  |
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Jan. 31, 2012 | Sep. 30, 2016 USD ($) shares | Sep. 30, 2015 USD ($) | Sep. 30, 2016 USD ($) Segment shares | Sep. 30, 2015 USD ($) shares | Dec. 31, 2015 USD ($) shares | Nov. 30, 2015 USD ($) | Jun. 30, 2015 Tranche | Mar. 05, 2015 USD ($) | Dec. 31, 2014 shares | May 31, 2014 USD ($) | Dec. 31, 2012 USD ($) | Dec. 06, 2012 USD ($)
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sales discount percentage |  | 2.00% |  | 2.00% |  |  |  |  |  |  |  |  |
Sales discount term |  |  |  | 30 days |  |  |  |  |  |  |  |  |
Trade receivables, credit period |  |  |  | 30 days |  |  |  |  |  |  |  |  |
Number of tranches for private placement transaction | Tranche |  |  |  |  |  |  |  | 2 |  |  |  |  |
Accounts receivable written off |  | $ 0 |  | $ 0 |  |  |  |  |  |  |  |  |
Other long-term assets |  | $ 682,000 |  | $ 682,000 |  | $ 174,000 |  |  |  |  |  |  |
Warrants outstanding | shares |  | 0 |  | 0 |  |  |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  | $ 3,610,000 | $ (230,000) | $ 8,170,000 | $ (366,000) |  |  |  |  |  |  |  |
Number of operating segments | Segment |  |  |  | 1 |  |  |  |  |  |  |  |  |
BioPharma Debt |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum repayment of future revenue and receivables |  | 128,800,000 |  | $ 128,800,000 |  |  |  |  |  |  |  |  | $ 150,000,000
Fair value of embedded derivative liability |  |  |  |  |  |  |  |  |  |  |  |  | $ 14,600,000
Gain (loss) on change in fair value of derivative liabilities |  |  |  | 5,500,000 | (300,000) |  |  |  |  |  |  |  |
Preferred Stock Purchase Option |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  |  | (946,000) |  |  |  |  |  |  |  |
Derivative liability at fair value |  |  |  |  |  |  |  |  | $ 900,000 |  |  |  |
Embedded Derivative Financial Instruments |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  | 8,170,000 | $ 470,000 |  |  |  |  |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  |  |  |  |  |  |  |  |  |  | $ 150,000,000 |
Fair value of embedded derivative liability |  | 0 |  | 0 |  | 5,500,000 |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  | $ 5,500,000 |  |  |  |  |  |  |  |  |
Top Three Customers | Gross Product Sales | Customer Concentration Risk |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk percentage |  |  |  | 95.00% | 95.00% |  |  |  |  |  |  |  |
Top Three Customers | Accounts Receivable | Customer Concentration Risk |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk percentage |  |  |  | 95.00% | 95.00% |  |  |  |  |  |  |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  |  |  |  |  |  | $ 27,900,000 |  |
Fair value of embedded derivative liability |  |  |  |  |  | 2,100,000 |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  | $ 2,100,000 | $ 800,000 |  |  |  |  |  |  |  |
Derivative liability at fair value |  |  |  |  |  |  |  |  |  |  | $ 3,500,000 |  |
Convertible Debt | 2015 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  |  | $ 3,800,000 |  |  |  |  |  |
Fair value of embedded derivative liability |  |  |  |  |  | $ 600,000 |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  | 600,000 |  |  |  |  |  |  |  |  |
Derivative liability at fair value |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |
Convertible Debt | 2014 Notes and 2015 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, dividend yield |  |  |  |  |  | 25.60% |  |  |  |  |  |  |
Derivative liability fair value assumptions, risk-free rate |  |  |  |  |  | 2.90% |  |  |  |  |  |  |
Derivative liability fair value assumptions, volatility rate |  |  |  |  |  | 89.00% |  |  |  |  |  |  |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  | $ 0 |  | $ 0 |  | $ 0 |  |  |  |  |  |  |
Note, expected term | 24 months |  |  |  |  |  |  |  |  |  |  |  |
Non Cash | Convertible Debt | 2014 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  | 24,100,000 |  |  |  |  |  |  |
Non Cash | Convertible Debt | 2015 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  | $ 4,200,000 |  |  |  |  |  |  |
Warrants Issued October 2009 |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants outstanding | shares |  | 0 |  | 0 |  | 0 |  |  |  | 8,087,388 |  |  |
Warrants exercised | shares |  |  |  |  | 1,844,585 |  |  |  |  |  |  |  |
Warrants expired | shares |  |  |  |  | 6,242,803 |  |  |  |  |  |  |  |
Accounting Standards Update 2015-03 | Convertible Debt | 2014 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Other long-term assets |  |  |  |  |  | $ (1,800,000) |  |  |  |  |  |  |
Accounting Standards Update 2015-03 | Convertible Debt | 2015 Notes |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Other long-term assets |  |  |  |  |  | (100,000) |  |  |  |  |  |  |
Accounting Standards Update 2015-03 | Scenario, Adjustment |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Other long-term assets |  |  |  |  |  | (1,900,000) |  |  |  |  |  |  |
Unamortized debt issuance cost |  |  |  |  |  | $ 1,900,000 |  |  |  |  |  |  |
ASU No. 2016-09 |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Excess tax provision on stock-based awards |  | $ 300,000 |  | $ 400,000 |  |  |  |  |  |  |  |  |
Deferred tax assets |  | $ 1,600,000 |  | $ 1,600,000 |  |  |  |  |  |  |  |  |
ASU No. 2016-09 | Scenario, Previously Reported |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Excess tax provision on stock-based awards |  |  |  |  | $ (700,000) |  |  |  |  |  |  |  |
ASU No. 2016-09 | Restatement Adjustment |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Excess tax provision on stock-based awards |  |  |  |  | $ 700,000 |  |  |  |  |  |  |  |
Minimum | Embedded Derivative Financial Instruments | BioPharma Debt |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, term |  |  |  | 1 year 3 months 18 days |  | 2 years |  |  |  |  |  |  |
Derivative liability fair value assumption, coupon rate |  |  |  | 6.60% |  | 6.60% |  |  |  |  |  |  |
Derivative liability fair value assumptions, market yields |  |  |  | 9.30% |  | 13.00% |  |  |  |  |  |  |
Maximum | Embedded Derivative Financial Instruments | BioPharma Debt |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, term |  |  |  | 5 years 7 months 6 days |  | 7 years 3 months 18 days |  |  |  |  |  |  |
Derivative liability fair value assumption, coupon rate |  |  |  | 12.50% |  | 12.50% |  |  |  |  |  |  |
Derivative liability fair value assumptions, market yields |  |  |  | 30.70% |  | 30.70% |  |  |  |  |  |  |

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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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