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Warrants and Warrant Derivative Liability - Additional Information (Detail) $ / shares in Units, $ in Thousands |  | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Oct. 16, 2009 USD ($) $ / shares shares | Mar. 31, 2015 USD ($) | Sep. 30, 2016 USD ($) shares | Sep. 30, 2015 USD ($) shares | Dec. 31, 2015 shares | Dec. 31, 2014 shares
Derivative [Line Items] |  |  |  |  |  |
Common stock issued under private placement, value | $ |  | $ 52,800 |  |  |  |
Issuance of common stock, net of transaction costs | $ |  |  | $ 64,614 |  |  |
Warrants outstanding |  |  | 0 |  |  |
Proceeds from exercise of warrants | $ |  |  |  | $ 2,713 |  |
Warrants Issued October 2009 |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Warrants outstanding |  |  | 0 |  | 0 | 8,087,388
Warrants exercised |  |  |  | 1,844,585 |  |
Proceeds from exercise of warrants | $ |  |  |  | $ 2,700 |  |
Warrants expired |  |  |  | 6,242,803 |  |
October 2009 Private Placement |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Common stock issued under private placement, value | $ | $ 70,000 |  |  |  |  |
Issuance of common stock, net of transaction costs | $ | $ 62,300 |  |  |  |  |
Common stock issued under private placement, shares | 66,400,000 |  |  |  |  |
Number of shares that each ADS represents | 1 |  |  |  |  |
Common stock issued under private placement, price per share | $ / shares | $ 1.00 |  |  |  |  |
October 2009 Private Placement | Warrants issued to three former officers |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Number of warrants issued | 900,000 |  |  |  |  |
October 2009 Private Placement | Bridge Loan |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Bridge notes converted in conjunction with the private placement, amount | $ | $ 3,600 |  |  |  |  |
Common stock issued under private placement, shares | 4,000,000 |  |  |  |  |
Number of shares that each ADS represents | 1 |  |  |  |  |
Bridge notes converted in conjunction with the private placement, price per share | $ / shares | $ 0.90 |  |  |  |  |
October 2009 Private Placement | Warrants Issued October 2009 |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Number of warrants issued | 35,200,000 |  |  |  |  |
Description of pricing variability feature and classification of warrants | The warrants issued in connection with the October 2009 financing contained a pricing variability feature which provided for an increase to the exercise price if the exchange rate between the U.S. dollar and British pound adjusts such that the warrants could be exercised at a price less than the £0.5 par value of the common stock-that is, if the exchange rate exceeded U.S. $3.00 per £1.0 sterling. Due to the potential variable nature of the exercise price, the warrants were not considered to be indexed to the Company’s common stock. Accordingly, the warrants did not qualify for the exception to classify the warrants within equity and were classified as a derivative liability. |  |  |  |  |
October 2009 Private Placement | Warrants Issued October 2009 | Maximum |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Warrants issued, number of shares called by the warrant | 36,100,000 |  |  |  |  |
October 2009 Private Placement | Warrants Issued October 2009 | American Depositary Shares |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Warrant term | 5 years |  |  |  |  |
Warrants issued, number of shares called by a warrant | 0.5 |  |  |  |  |
Exercise price of the warrants | $ / shares | $ 1.50 |  |  |  |  |
October 2009 Private Placement | Warrants Issued October 2009 | Bridge Loan | American Depositary Shares |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |
Warrant term | 5 years |  |  |  |  |
Warrants issued, number of shares called by a warrant | 0.5 |  |  |  |  |
Exercise price of the warrants | $ / shares | $ 1.50 |  |  |  |  |

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