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Nature of Business and Basis of Presentation - Additional Information (Detail)
$ in Thousands
 1 Months Ended 9 Months Ended
May 31, 2014
USD ($)
Jan. 31, 2012
USD ($)
Sep. 30, 2016
USD ($)
Segment
Patient
Employee
shares
Dec. 31, 2015
USD ($)
Nov. 30, 2015
USD ($)
Sep. 30, 2015
USD ($)
Dec. 31, 2014
USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Number of operating segments | Segment     1        
REDUCE-IT study, number of patients enrolled and randomized | Patient     8,175        
Cash and cash equivalents     $ 117,562 $ 106,961   $ 118,976 $ 119,539
Total current assets     161,180 143,524      
Proceeds from issuance of common stock, net of transaction costs     64,614        
American Depositary Shares              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Proceeds from issuance of common stock, net of transaction costs     $ 64,614        
Issuance of common stock, net of transaction costs (shares) | shares     24,265,000        
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Number of sales professionals | Employee     150        
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Number of sales representatives | Employee     250        
Convertible Debt | 2012 Notes              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, earliest redemption date   Jan. 19, 2017          
Convertible senior notes, put dates     May be put back to the Company by the holders on each of January 19, 2017, 2022 and 2027 for cash        
Convertible senior notes, repurchase price at option of the issuer   100.00%          
Convertible notes, carrying amount net of unamortized discount     $ 15,100 15,100      
Convertible senior notes, principal amount $ 31,300 $ 150,000     $ 15,100    
Convertible Debt | 2014 Notes              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible senior notes, repurchase price at option of the issuer 100.00%            
Convertible notes, carrying amount net of unamortized discount     0 94,600      
Convertible senior notes, principal amount $ 118,700   118,700        
Convertible Debt | 2015 Notes              
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]              
Convertible notes, carrying amount net of unamortized discount     0 $ 27,000      
Convertible senior notes, principal amount     $ 31,300