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Debt - Additional Information (Detail)
 1 Months Ended 3 Months Ended 9 Months Ended
Dec. 06, 2012
USD ($)
Sep. 30, 2016
USD ($)
Nov. 30, 2015
USD ($)
shares
$ / shares
May 31, 2014
USD ($)
shares
d
$ / shares
Jan. 31, 2012
USD ($)
shares
$ / shares
Sep. 30, 2016
USD ($)
shares
Dec. 31, 2015
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
shares
Sep. 30, 2015
USD ($)
Debt Disclosure [Line Items]                    
Gain (Loss) on change in fair value of derivative liability           $ 3,610,000   $ (230,000) $ 8,170,000 $ (366,000)
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   $ 93,055,000       93,055,000 $ 91,512,000   93,055,000  
Current portion of exchangeable senior notes, net of discount   15,273,000       15,273,000 2,266,000   15,273,000  
Carrying amount of debt conversion option   11,500,000       11,500,000 11,500,000   11,500,000  
Interest payment on notes                 13,839,000 10,225,000
Convertible senior notes, principal amount                 128,115,000  
Exchangeable senior notes, net of discount             136,734,000      
Other long-term assets   682,000       682,000 174,000   682,000  
Convertible senior notes, carrying value, exchanged   127,300,000       127,300,000     127,300,000  
Carrying amount of debt conversion option                 127,437,000  
Transaction costs                 $ 678,000  
Common Stock                    
Debt Disclosure [Line Items]                    
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares                 60,311,188  
Carrying amount of debt conversion option                 $ 40,062,000  
Accounting Standards Update 2015-03 | 2014 Notes                    
Debt Disclosure [Line Items]                    
Exchangeable senior notes, net of discount             1,800,000      
Accounting Standards Update 2015-03 | 2015 Notes                    
Debt Disclosure [Line Items]                    
Exchangeable senior notes, net of discount             100,000      
Convertible Debt                    
Debt Disclosure [Line Items]                    
Convertible senior notes, principal amount                 $ 150,000,000  
Convertible Debt | American Depositary Shares                    
Debt Disclosure [Line Items]                    
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares                 60,311,188  
Transaction costs                 $ 700,000  
Convertible Debt | 2012 Notes                    
Debt Disclosure [Line Items]                    
Interest expense, contractual coupon interest                 400,000 800,000
Convertible senior notes, principal amount     $ 15,100,000 $ 31,300,000 $ 150,000,000          
Convertible senior notes, stated interest rate         3.50%          
Current portion of exchangeable senior notes, net of discount   15,100,000       15,100,000     15,100,000  
Convertible senior notes, due date         2032          
Proceeds from issuance of convertible debt, net of transaction costs         $ 144,300,000          
Convertible senior notes, payment start date         Jul. 15, 2012          
Convertible senior notes, maturity date         Jan. 15, 2032          
Value of shares in excess of principal amount of Notes based on closing price   9,600,000       9,600,000     9,600,000  
Additional interest rate on notes per annum         0.50%          
Convertible senior notes, repurchase price at option of the issuer         100.00%          
Carrying amount of debt conversion option         $ 23,800,000          
Convertible senior notes, fair value   15,084,000       15,084,000 13,637,000   15,084,000  
Note, estimated remaining life         24 months          
Convertible notes, carrying amount net of unamortized discount   15,100,000       15,100,000 15,100,000   15,100,000  
Accrued interest on convertible note   200,000       200,000 300,000   200,000  
Convertible senior notes, discount   0       0 0   0  
Gain on extinguishment of debt             1,300,000      
Convertible senior notes, repayment     15,900,000              
Convertible senior notes, principal amount purchase     $ 16,200,000              
Convertible Debt | 2012 Notes | Finance                    
Debt Disclosure [Line Items]                    
Interest payment on notes                 500,000 1,100,000
Convertible Debt | 2012 Notes | American Depositary Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes         113.4752          
Convertible senior notes, total ADS into which the debt is exchangeable | shares         1,714,270          
Convertible senior notes, initial exchange price | $ / shares         $ 8.8125          
Convertible Debt | 2014 Notes                    
Debt Disclosure [Line Items]                    
Fair value of embedded derivative liability             2,100,000      
Gain (Loss) on change in fair value of derivative liability                 2,100,000 800,000
Interest expense, contractual coupon interest                 2,900,000 3,100,000
Convertible notes, interest expense                 7,700,000 7,700,000
Convertible senior notes, principal amount   118,700,000   $ 118,700,000   118,700,000     118,700,000  
Convertible senior notes, stated interest rate       3.50%            
Convertible senior notes, due date       2032            
Convertible senior notes, payment start date       Jul. 15, 2014            
Convertible senior notes, maturity date       Jan. 15, 2032            
Convertible senior notes, repurchase price at option of the issuer       100.00%            
Convertible senior notes, fair value       $ 90,800,000     108,034,000      
Convertible notes, carrying amount net of unamortized discount   0       0 94,600,000   0  
Accrued interest on convertible note   0       0 1,900,000   0  
Convertible senior notes, principal amount   118,700,000   $ 118,700,000   118,700,000        
Exchangeable senior notes, net of discount   0       $ 0     0  
Convertible senior notes redemption, end date       Jan. 15, 2032            
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days | d       30            
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes       $ 10,100,000            
Convertible senior notes, discount       27,900,000            
Offering costs       2,500,000            
Gain on extinguishment of debt       38,000,000            
Derivative liability at fair value       $ 3,500,000            
Convertible Debt | 2014 Notes | Non Cash                    
Debt Disclosure [Line Items]                    
Convertible notes, interest expense                 4,800,000 4,600,000
Convertible senior notes, discount             24,100,000      
Convertible Debt | 2014 Notes | Finance                    
Debt Disclosure [Line Items]                    
Interest payment on notes                 4,200,000 4,200,000
Convertible Debt | 2014 Notes | American Depositary Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes       384.6154            
Convertible senior notes, total ADS into which the debt is exchangeable | shares       45,666,925            
Convertible senior notes, initial exchange price | $ / shares       $ 2.60            
Convertible Debt | 2014 Notes | Final As-Adjusted | American Depositary Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes           402.0746        
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares           47,739,925        
Convertible Debt | 2015 Notes                    
Debt Disclosure [Line Items]                    
Fair value of embedded derivative liability             600,000      
Gain (Loss) on change in fair value of derivative liability                 600,000  
Interest expense, contractual coupon interest                 800,000  
Convertible notes, interest expense                 1,700,000  
Convertible senior notes, principal amount   31,300,000       $ 31,300,000     31,300,000  
Convertible senior notes, stated interest rate     3.50%              
Convertible senior notes, due date     2032              
Proceeds from issuance of convertible debt, net of transaction costs     $ 27,500,000              
Convertible senior notes, fair value     27,500,000       28,448,000      
Convertible notes, carrying amount net of unamortized discount   0       0 27,000,000   0  
Accrued interest on convertible note   0       0 100,000   0  
Convertible senior notes, principal amount     31,300,000     31,300,000        
Exchangeable senior notes, net of discount   0       $ 0     0  
Convertible senior notes, discount     3,800,000              
Offering costs     100,000              
Derivative liability at fair value     $ 500,000              
Equity component of convertible notes issuance cost                 87,400,000  
Debt instrument increase accrued interest                 800,000  
Convertible Debt | 2015 Notes | Non Cash                    
Debt Disclosure [Line Items]                    
Convertible notes, interest expense                 900,000  
Convertible senior notes, discount             4,200,000      
Convertible Debt | 2015 Notes | Finance                    
Debt Disclosure [Line Items]                    
Interest payment on notes                 700,000  
Convertible Debt | 2015 Notes | American Depositary Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes     384.6154              
Convertible senior notes, total ADS into which the debt is exchangeable | shares     12,025,385              
Convertible senior notes, initial exchange price | $ / shares     $ 2.60              
Convertible Debt | 2015 Notes | Final As-Adjusted | American Depositary Shares                    
Debt Disclosure [Line Items]                    
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes           402.0746        
Exchange of exchangeable senior notes, net of transaction costs (shares) | shares           12,571,263        
Convertible Debt | Other debt outstanding | 2012 Notes                    
Debt Disclosure [Line Items]                    
Convertible senior notes, fair value         $ 126,200,000          
Convertible Debt | Minimum | 2014 Notes                    
Debt Disclosure [Line Items]                    
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price       110.00%            
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days       20 days            
Convertible Debt | Common Stock                    
Debt Disclosure [Line Items]                    
Carrying amount of debt conversion option                 40,100,000  
Convertible Debt | Accounting Standards Update 2015-03 | 2014 Notes                    
Debt Disclosure [Line Items]                    
Other long-term assets             (1,800,000)      
Convertible Debt | Accounting Standards Update 2015-03 | 2015 Notes                    
Debt Disclosure [Line Items]                    
Other long-term assets             (100,000)      
BioPharma Debt                    
Debt Disclosure [Line Items]                    
Amount received at the closing of the agreement $ 100,000,000                  
Maximum repayment of future revenue and receivables 150,000,000 128,800,000       $ 128,800,000     128,800,000  
Repayment under agreement           3,300,000     8,500,000  
Fair value of embedded derivative liability $ 14,600,000                  
Gain (Loss) on change in fair value of derivative liability                 5,500,000 (300,000)
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   93,100,000       93,100,000 $ 91,500,000   93,100,000  
BioPharma Debt | Cash                    
Debt Disclosure [Line Items]                    
Interest expense, contractual coupon interest                 5,000,000 4,900,000
BioPharma Debt | Non Cash                    
Debt Disclosure [Line Items]                    
Convertible notes, interest expense                 1,500,000 $ 1,400,000
BioPharma Debt | November 2016                    
Debt Disclosure [Line Items]                    
Future minimum repayment under agreement   3,200,000       3,200,000     3,200,000  
BioPharma Debt | First quarter of 2017                    
Debt Disclosure [Line Items]                    
Future minimum repayment under agreement   15,000,000       15,000,000     15,000,000  
BioPharma Debt | May 2017                    
Debt Disclosure [Line Items]                    
Future minimum repayment under agreement   $ 13,000,000       $ 13,000,000     $ 13,000,000