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Co-Promotion Agreement - Additional Information (Detail) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2017 USD ($) Employee | Dec. 31, 2016 USD ($) | Dec. 31, 2015
Co Promotion Agreement [Line Items] |  |  |
Accrued expenses and other current liabilities | $ 44,434 | $ 37,720 |
Co-Promotion Agreement (the Agreement) |  |  |
Co Promotion Agreement [Line Items] |  |  |
Promotion fee as a percentage of gross margin | 20.00% | 19.00% | 15.00%
Promotion fee as a percentage gross margin | scheduled to increase to low twenty percent levels in 2018, subject to certain adjustments |  |
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America |  |  |
Co Promotion Agreement [Line Items] |  |  |
Accrued expenses and other current liabilities | $ 8,900 | $ 2,500 |
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum |  |  |
Co Promotion Agreement [Line Items] |  |  |
Number of sales representatives | Employee | 250 |  |

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