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Co-Promotion Agreement - Additional Information (Detail)
$ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2017
USD ($)
Employee
Dec. 31, 2016
USD ($)
Dec. 31, 2015
Co Promotion Agreement [Line Items]      
Accrued expenses and other current liabilities $ 44,434 $ 37,720  
Co-Promotion Agreement (the Agreement)      
Co Promotion Agreement [Line Items]      
Promotion fee as a percentage of gross margin 20.00% 19.00% 15.00%
Promotion fee as a percentage gross margin scheduled to increase to low twenty percent levels in 2018, subject to certain adjustments    
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America      
Co Promotion Agreement [Line Items]      
Accrued expenses and other current liabilities $ 8,900 $ 2,500  
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum      
Co Promotion Agreement [Line Items]      
Number of sales representatives | Employee 250