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Debt - Long-Term Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) - USD ($) |  | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | ---
Dec. 06, 2012 | Sep. 30, 2017 | Sep. 30, 2016 | Sep. 30, 2017 | Sep. 30, 2016 | Dec. 31, 2016
Debt Disclosure [Line Items] |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  | $ 3,610,000 |  | $ 8,170,000 |
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount |  | $ 95,183,000 |  | $ 95,183,000 |  | $ 93,592,000
BioPharma Debt |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |
Amount received at the closing of the agreement | $ 100,000,000 |  |  |  |  |
Maximum repayment of future revenue and receivables | 150,000,000 | 113,800,000 |  | 113,800,000 |  |
Repayment under agreement |  | 4,500,000 |  | 11,800,000 |  |
Fair value of embedded derivative liability | $ 14,600,000 |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  | 0 | 5,500,000 |
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount |  | 95,200,000 |  | 95,200,000 |  | $ 93,600,000
BioPharma Debt | Cash |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |
Interest expense, contractual coupon interest |  |  |  | 4,800,000 | 5,000,000 |
BioPharma Debt | Non Cash |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |
Convertible notes, interest expense |  |  |  | 1,600,000 | $ 1,500,000 |
BioPharma Debt | May 2017 |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |
Future minimum repayment under agreement |  | $ 4,700,000 |  | $ 4,700,000 |  |

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- Definition Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 50 -Paragraph 4B -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=84234895&loc=SL5624163-113959 + Details
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- Definition Amount of the cost of borrowed funds accounted for as interest expense for debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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- Definition Represents the portion of interest incurred in the period on debt arrangements that was charged against earnings, excluding amortization of debt discount (premium) and financing costs. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph 8 -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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- Definition Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(16)) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(16)) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Minimum amount of other commitment not otherwise specified in the taxonomy. Excludes commitments explicitly modeled in the taxonomy, including but not limited to, long-term and short-term purchase commitments, recorded and unrecorded purchase obligations, supply commitments, registration payment arrangements, leases, debt, product warranties, guarantees, environmental remediation obligations, and pensions. + References No definition available. + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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