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Significant Accounting Policies - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |  |  |  |
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Jan. 31, 2017 USD ($) | Jan. 31, 2012 | Mar. 31, 2017 USD ($) | Sep. 30, 2016 USD ($) | Sep. 30, 2017 USD ($) Segment | Sep. 30, 2016 USD ($) | Dec. 31, 2016 USD ($) | Jan. 20, 2017 USD ($) | Dec. 31, 2015 USD ($) | Nov. 30, 2015 USD ($) | May 31, 2014 USD ($) | Dec. 31, 2012 USD ($)
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Sales discount percentage |  |  |  |  | 2.00% |  |  |  |  |  |  |
Trade receivables, credit period |  |  |  |  | 30 days |  |  |  |  |  |  |
Accounts receivable written off |  |  |  |  | $ 0 |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  | $ 3,610,000 |  | $ 8,170,000 |  |  |  |  |  |
Number of operating segments | Segment |  |  |  |  | 1 |  |  |  |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  |  |  |  |  |  |  |  |  |  | $ 150,000,000
Fair value of embedded derivative liability |  |  |  | $ 0 | $ 0 | 0 | $ 0 |  | $ 5,500,000 |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  |  | $ 0 | $ 5,500,000 |  |  |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt | Minimum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, term |  |  |  |  | 2 years 6 months |  | 2 years 4 months 24 days |  |  |  |  |
Derivative liability fair value assumption, coupon rate |  |  |  |  | 5.80% |  | 8.10% |  |  |  |  |
Derivative liability fair value assumptions, market yields |  |  |  |  | 9.10% |  | 11.90% |  |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt | Maximum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, term |  |  |  |  | 4 years 6 months |  | 5 years |  |  |  |  |
Derivative liability fair value assumption, coupon rate |  |  |  |  | 10.80% |  | 11.10% |  |  |  |  |
Derivative liability fair value assumptions, market yields |  |  |  |  | 17.50% |  | 18.40% |  |  |  |  |
Top Three Customers | Gross Product Sales | Customer Concentration Risk |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk percentage |  |  |  |  | 90.00% | 95.00% |  |  |  |  |  |
Top Three Customers | Accounts Receivable | Customer Concentration Risk |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk percentage |  |  |  |  | 87.00% | 95.00% |  |  |  |  |  |
2012 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount of notes | $ 15,000,000 |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount redeemed | 100,000 |  |  |  |  |  |  |  |  |  |  |
2017 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount of notes |  |  |  |  | $ 30,000,000 |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  | $ 1,200,000 |  |  |  |  |  |  |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount of notes |  |  |  |  |  |  | $ 15,107,000 |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  |  | $ 0 |  |  |  |  |
Note, expected term |  | 24 months |  |  | 24 months |  |  |  |  |  |  |
Convertible senior notes, principal amount purchase | $ 15,000,000 |  | $ 15,000,000 |  |  |  |  |  |  | $ 16,200,000 |  |
Convertible senior notes, aggregate principal amount redeemed |  |  | $ 100,000 |  | $ 100,000 |  |  |  |  |  |  |
Convertible senior notes, outstanding amount |  |  |  |  | 0 |  |  |  |  |  |  |
Convertible Debt | 2017 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  | 1,100,000 |  |  | $ 1,200,000 |  |  |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  |  |  |  |  |  | $ 27,900,000 |
Fair value of embedded derivative liability |  |  |  |  |  |  |  |  | 2,100,000 |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  |  |  | $ 2,100,000 |  |  |  |  |  |
Convertible Debt | 2014 Notes and 2015 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  |  | $ 0 |  |  |  |  |  |  |
Convertible Debt | 2015 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  |  |  |  |  | $ 3,800,000 |  |
Fair value of embedded derivative liability |  |  |  |  |  |  |  |  | $ 600,000 |  |  |
Gain (loss) on change in fair value of derivative liabilities |  |  |  |  |  | $ 600,000 |  |  |  |  |  |

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