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Significant Accounting Policies - Additional Information (Detail)	1 Months Ended		3 Months Ended		9 Months Ended		12 Months Ended
	Jan. 31, 2017 USD ($)	Jan. 31, 2012	Mar. 31, 2017 USD ($)	Sep. 30, 2016 USD ($)	Sep. 30, 2017 USD ($) Segment	Sep. 30, 2016 USD ($)	Dec. 31, 2016 USD ($)	Jan. 20, 2017 USD ($)	Dec. 31, 2015 USD ($)	Nov. 30, 2015 USD ($)	May 31, 2014 USD ($)	Dec. 31, 2012 USD ($)
Significant Accounting Policies [Line Items]
Sales discount percentage					2.00%
Trade receivables, credit period					30 days
Accounts receivable written off					$ 0
Gain (loss) on change in fair value of derivative liabilities				$ 3,610,000		$ 8,170,000
Number of operating segments | Segment					1
Embedded Derivative Financial Instruments | BioPharma Debt
Significant Accounting Policies [Line Items]
Maximum repayment of future revenue and receivables												$ 150,000,000
Fair value of embedded derivative liability				$ 0	$ 0	0	$ 0		$ 5,500,000
Gain (loss) on change in fair value of derivative liabilities					$ 0	$ 5,500,000
Embedded Derivative Financial Instruments | BioPharma Debt | Minimum
Significant Accounting Policies [Line Items]
Derivative liability fair value assumptions, term					2 years 6 months		2 years 4 months 24 days
Derivative liability fair value assumption, coupon rate					5.80%		8.10%
Derivative liability fair value assumptions, market yields					9.10%		11.90%
Embedded Derivative Financial Instruments | BioPharma Debt | Maximum
Significant Accounting Policies [Line Items]
Derivative liability fair value assumptions, term					4 years 6 months		5 years
Derivative liability fair value assumption, coupon rate					10.80%		11.10%
Derivative liability fair value assumptions, market yields					17.50%		18.40%
Top Three Customers | Gross Product Sales | Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage					90.00%	95.00%
Top Three Customers | Accounts Receivable | Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage					87.00%	95.00%
2012 Notes
Significant Accounting Policies [Line Items]
Aggregate principal amount of notes	$ 15,000,000
Aggregate principal amount redeemed	100,000
2017 Notes
Significant Accounting Policies [Line Items]
Aggregate principal amount of notes					$ 30,000,000
Convertible senior notes, discount					$ 1,200,000
Convertible Debt | 2012 Notes
Significant Accounting Policies [Line Items]
Aggregate principal amount of notes							$ 15,107,000
Convertible senior notes, discount							$ 0
Note, expected term		24 months			24 months
Convertible senior notes, principal amount purchase	$ 15,000,000		$ 15,000,000							$ 16,200,000
Convertible senior notes, aggregate principal amount redeemed			$ 100,000		$ 100,000
Convertible senior notes, outstanding amount					0
Convertible Debt | 2017 Notes
Significant Accounting Policies [Line Items]
Convertible senior notes, discount					1,100,000			$ 1,200,000
Convertible Debt | 2014 Notes
Significant Accounting Policies [Line Items]
Convertible senior notes, discount											$ 27,900,000
Fair value of embedded derivative liability									2,100,000
Gain (loss) on change in fair value of derivative liabilities						$ 2,100,000
Convertible Debt | 2014 Notes and 2015 Notes
Significant Accounting Policies [Line Items]
Gain (loss) on change in fair value of derivative liabilities					$ 0
Convertible Debt | 2015 Notes
Significant Accounting Policies [Line Items]
Convertible senior notes, discount										$ 3,800,000
Fair value of embedded derivative liability									$ 600,000
Gain (loss) on change in fair value of derivative liabilities						$ 600,000

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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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Amount, after accumulated amortization, of debt discount.

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Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.

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Minimum amount of other commitment not otherwise specified in the taxonomy. Excludes commitments explicitly modeled in the taxonomy, including but not limited to, long-term and short-term purchase commitments, recorded and unrecorded purchase obligations, supply commitments, registration payment arrangements, leases, debt, product warranties, guarantees, environmental remediation obligations, and pensions.

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The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations.

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