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Co-Promotion Agreement - Additional Information (Detail) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2017
Dec. 31, 2016
Co Promotion Agreement [Line Items]    
Accrued expenses and other current liabilities $ 51,627 $ 37,720
Co-Promotion Agreement (the Agreement)    
Co Promotion Agreement [Line Items]    
Promotion fee as a percentage of gross margin 18.00%  
Promotion fee as a percentage gross margin scheduled, as amended, to be approximately eighteen percent (18%) in 2017, partially offset by certain other refinements  
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America    
Co Promotion Agreement [Line Items]    
Agreement amended date Jul. 25, 2017  
Accrued expenses and other current liabilities $ 6,000 $ 2,500