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Development, Commercialization and Supply Agreement - Additional Information (Detail)
1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2017
USD ($)
Mar. 31, 2016
USD ($)
Feb. 28, 2015
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2017
USD ($)
Item
Sep. 30, 2016
USD ($)
Dec. 31, 2016
USD ($)
License And Collaboration Agreements [Line Items]                
Licensing revenue       $ 309,000 $ 293,000 $ 895,000 $ 825,000  
Deferred revenue $ 19,200,000     $ 19,200,000   $ 19,200,000   $ 15,100,000
Eddingpharm                
License And Collaboration Agreements [Line Items]                
Non-refundable up-front received     $ 15,000,000          
Licensing agreement term     16 years          
Number of indications of the regulatory milestone events relating to the submission and approval | Item           3    
Amounts to be received upon achievement of the regulatory milestone events           $ 33,000,000    
Sales-based milestone event payment           120,000,000    
Eddingpharm | Maximum                
License And Collaboration Agreements [Line Items]                
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone           153,000,000    
Amounts to be received upon achievement of the regulatory milestone events           15,000,000    
Sales-based milestone event payment           50,000,000    
Eddingpharm | Minimum                
License And Collaboration Agreements [Line Items]                
Amounts to be received upon achievement of the regulatory milestone events           1,000,000    
Sales-based milestone event payment           5,000,000    
Eddingpharm | Clinical Trial Application                
License And Collaboration Agreements [Line Items]                
Licensing agreement term   4 years            
Non-refundable milestone payment   $ 1,000,000            
Biologix FZCo                
License And Collaboration Agreements [Line Items]                
Revenue recognition period of non-refundable up-front payment   10 years            
HLS                
License And Collaboration Agreements [Line Items]                
Non-refundable up-front received $ 5,000,000              
Licensing agreement term 12 years 6 months              
Non-refundable up-front received period 6 months              
HLS | Maximum                
License And Collaboration Agreements [Line Items]                
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone           $ 60,000,000