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Debt - Long-Term Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) - USD ($) |  | 3 Months Ended |
--- | --- | --- | ---
Dec. 06, 2012 | Mar. 31, 2018 | Mar. 31, 2017 | Dec. 31, 2017
Debt Disclosure [Line Items] |  |  |  |
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount |  | $ 89,135,000 |  | $ 92,403,000
Interest expense, non-cash |  | 573,000 | $ 563,000 |
CPPIB |  |  |  |
Debt Disclosure [Line Items] |  |  |  |
Maximum repayment of future revenue and receivables |  | 103,800,000 |  |
Repayment under agreement |  | 5,300,000 |  |
Future minimum repayment under agreement |  | 4,400,000 |  |
BioPharma Debt |  |  |  |
Debt Disclosure [Line Items] |  |  |  |
Amount received at the closing of the agreement | $ 100,000,000 |  |  |
Maximum repayment of future revenue and receivables | 150,000,000 |  |  |
Royalty-Bearing Debt |  |  |  |
Debt Disclosure [Line Items] |  |  |  |
Fair value of embedded derivative liability | $ 14,600,000 |  |  |
Gain (loss) on change in fair value of derivative liabilities |  | 0 | 0 |
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount |  | 89,100,000 |  | $ 93,600,000
Royalty-Bearing Debt | Cash |  |  |  |
Debt Disclosure [Line Items] |  |  |  |
Interest expense, contractual coupon interest |  | 1,500,000 | 1,600,000 |
Royalty-Bearing Debt | Non Cash |  |  |  |
Debt Disclosure [Line Items] |  |  |  |
Interest expense, non-cash |  | $ 500,000 | $ 500,000 |

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- Definition Amount of amortization expense attributable to debt discount (premium) and debt issuance costs. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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- Definition Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 50 -Paragraph 4B -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=84234895&loc=SL5624163-113959 + Details
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- Definition Represents the portion of interest incurred in the period on debt arrangements that was charged against earnings, excluding amortization of debt discount (premium) and financing costs. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph 8 -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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- Definition Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(16)) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(16)) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Minimum amount of other commitment not otherwise specified in the taxonomy. Excludes commitments explicitly modeled in the taxonomy, including but not limited to, long-term and short-term purchase commitments, recorded and unrecorded purchase obligations, supply commitments, registration payment arrangements, leases, debt, product warranties, guarantees, environmental remediation obligations, and pensions. + References No definition available. + Details
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