Accounts receivable credit period

No definition available.

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- Definition

Fair value assumptions, comparable yield to maturity.

+ References

No definition available.

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- Definition

Fair value assumptions coupon rate.

+ References

No definition available.

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- Definition

Significant accounting policies.

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No definition available.

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- Definition

For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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- Definition

Amount, after accumulated amortization, of debt discount.

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- Definition

Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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- Definition

Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.

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- Definition

Period the instrument, asset or liability is expected to be outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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- Definition

Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues.

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No definition available.

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- Definition

Minimum amount of other commitment not otherwise specified in the taxonomy. Excludes commitments explicitly modeled in the taxonomy, including but not limited to, long-term and short-term purchase commitments, recorded and unrecorded purchase obligations, supply commitments, registration payment arrangements, leases, debt, product warranties, guarantees, environmental remediation obligations, and pensions.

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No definition available.

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- Definition

The cumulative amount of the reporting entity's undistributed earnings or deficit.

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- Definition

Including the current and noncurrent portions, carrying value as of the balance sheet date of Notes with the highest claim on the assets of the issuer in case of bankruptcy or liquidation (with maturities initially due after one year or beyond the operating cycle if longer). Senior note holders are paid off in full before any payments are made to junior note holders.

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- Definition

The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period.

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Significant Accounting Policies - Additional Information (Detail)	3 Months Ended		12 Months Ended
	Mar. 31, 2018 USD ($) Segment	Mar. 31, 2017 USD ($)	Dec. 31, 2017 USD ($)	Jan. 01, 2018 USD ($)	Jan. 20, 2017 USD ($)	Dec. 31, 2012 USD ($)
Significant Accounting Policies [Line Items]
Trade receivables, credit period	30 days
U.S. federal corporate tax rate	21.00%		34.00%
Number of operating segments \| Segment	1
Accumulated deficit	$ (1,296,182,000)		$ (1,271,869,000)
Difference between Revenue Guidance in Effect before and after Topic 606 \| Accounting Standards Update 2014-09
Significant Accounting Policies [Line Items]
Accumulated deficit				$ 200,000
Minimum
Significant Accounting Policies [Line Items]
Trade receivables, credit period	30 days
Maximum
Significant Accounting Policies [Line Items]
Trade receivables, credit period	60 days
Embedded Derivative Financial Instruments \| BioPharma Debt
Significant Accounting Policies [Line Items]
Maximum repayment of future revenue and receivables						$ 150,000,000
Fair value of embedded derivative liability	$ 0		$ 0
Gain (loss) on change in fair value of derivative liabilities	$ 0	$ 0
Embedded Derivative Financial Instruments \| BioPharma Debt \| Minimum
Significant Accounting Policies [Line Items]
Derivative liability fair value assumptions, term	2 years		2 years 3 months 18 days
Derivative liability fair value assumption, coupon rate	5.80%		5.80%
Derivative liability fair value assumptions, market yields	7.80%		10.20%
Embedded Derivative Financial Instruments \| BioPharma Debt \| Maximum
Significant Accounting Policies [Line Items]
Derivative liability fair value assumptions, term	4 years		4 years 3 months 18 days
Derivative liability fair value assumption, coupon rate	10.80%		10.80%
Derivative liability fair value assumptions, market yields	12.70%		18.40%
Customer A \| Gross Product Sales \| Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage	26.00%	30.00%
Customer A \| Accounts Receivable \| Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage	37.00%	44.00%
Customer B \| Gross Product Sales \| Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage	31.00%	27.00%
Customer B \| Accounts Receivable \| Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage	30.00%	22.00%
Customer C \| Gross Product Sales \| Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage	31.00%	38.00%
Customer C \| Accounts Receivable \| Customer Concentration Risk
Significant Accounting Policies [Line Items]
Concentration risk percentage	24.00%	31.00%
2017 Notes
Significant Accounting Policies [Line Items]
Aggregate principal amount of notes	$ 30,000,000
Convertible senior notes, discount	1,200,000
Convertible Debt \| 2017 Notes
Significant Accounting Policies [Line Items]
Convertible senior notes, discount	$ 1,000,000		$ 1,000,000		$ 1,200,000