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Debt - Long-Term Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) - USD ($)
 3 Months Ended
Dec. 06, 2012
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Debt Disclosure [Line Items]        
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   $ 89,135,000   $ 92,403,000
Interest expense, non-cash   573,000 $ 563,000  
CPPIB        
Debt Disclosure [Line Items]        
Maximum repayment of future revenue and receivables   103,800,000    
Repayment under agreement   5,300,000    
Future minimum repayment under agreement   4,400,000    
BioPharma Debt        
Debt Disclosure [Line Items]        
Amount received at the closing of the agreement $ 100,000,000      
Maximum repayment of future revenue and receivables 150,000,000      
Royalty-Bearing Debt        
Debt Disclosure [Line Items]        
Fair value of embedded derivative liability $ 14,600,000      
Gain (loss) on change in fair value of derivative liabilities   0 0  
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   89,100,000   $ 93,600,000
Royalty-Bearing Debt | Cash        
Debt Disclosure [Line Items]        
Interest expense, contractual coupon interest   1,500,000 1,600,000  
Royalty-Bearing Debt | Non Cash        
Debt Disclosure [Line Items]        
Interest expense, non-cash   $ 500,000 $ 500,000