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Commitments and Contingencies - Additional Information (Detail) - 3 months ended Mar. 31, 2018	USD ($)	GBP (£)
Further Indication for AMR101 | Marketing Approval In Europe
Commitments And Contingencies Disclosure [Line Items]
Potential aggregate stock or cash payment	$ 10,500,000	£ 7,500,000
Further Indication for AMR101 | Potential Marketing Approval 1
Commitments And Contingencies Disclosure [Line Items]
Potential aggregate stock or cash payment	7,000,000	5,000,000
Further Indication for AMR101 | Potential Marketing Approval 2
Commitments And Contingencies Disclosure [Line Items]
Potential aggregate stock or cash payment	7,000,000	5,000,000
Further Indication for AMR101 | Maximum
Commitments And Contingencies Disclosure [Line Items]
Potential aggregate stock or cash payment	14,000,000	£ 10,000,000
Nisshin
Commitments And Contingencies Disclosure [Line Items]
Royalty, milestone or minimum purchase commitments	$ 0

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Commitments and contingencies disclosure.

+ References

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The amount the entity has committed to make for future royalty guarantees.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 928
-SubTopic 440
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6473578&loc=d3e63223-108013

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