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Co-Promotion Agreement - Additional Information (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Dec. 31, 2017
Co Promotion Agreement [Line Items]    
Accrued expenses and other current liabilities $ 61,311 $ 58,902
Co-Promotion Agreement (the Agreement)    
Co Promotion Agreement [Line Items]    
Promotion fee as a percentage of gross margin 18.00%  
Promotion fee as a percentage gross margin amended, approximately eighteen percent (18%) in 2017, partially offset by certain other refinements  
Maximum co-promotion tail payments receive period 3 years  
Accrued co- promotion tail payments $ 3,400  
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America    
Co Promotion Agreement [Line Items]    
Agreement amended date Jul. 25, 2017  
Accrued expenses and other current liabilities $ 9,600 $ 8,300