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Debt - Long-Term Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) - USD ($)
 3 Months Ended 6 Months Ended
Dec. 06, 2012
Jun. 30, 2018
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Debt Disclosure [Line Items]          
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   $ 86,718,000 $ 86,718,000   $ 92,403,000
Interest expense, non-cash     1,140,000 $ 1,147,000  
CPPIB          
Debt Disclosure [Line Items]          
Maximum repayment of future revenue and receivables   99,400,000 99,400,000    
Repayment under agreement   4,400,000 9,700,000    
Future minimum repayment under agreement   5,300,000 5,300,000    
BioPharma Debt          
Debt Disclosure [Line Items]          
Amount received at the closing of the agreement $ 100,000,000        
Maximum repayment of future revenue and receivables 150,000,000        
Royalty-Bearing Debt          
Debt Disclosure [Line Items]          
Fair value of embedded derivative liability $ 14,600,000        
Gain (loss) on change in fair value of derivative liabilities     0 0  
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   $ 86,700,000 86,700,000   $ 92,400,000
Royalty-Bearing Debt | Cash          
Debt Disclosure [Line Items]          
Interest expense, contractual coupon interest     3,000,000 3,200,000  
Royalty-Bearing Debt | Non Cash          
Debt Disclosure [Line Items]          
Interest expense, non-cash     $ 1,000,000 $ 1,100,000