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Summarize Activity of the Net Product Revenue Allowance and Reserve Categories (Detail) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance $ 48,093 $ 27,198
Provision related to current period sales 106,853 76,790
Provision related to prior period sales (1,305) (1,221)
Credits/payments made for current period sales (56,177) (45,210)
Credits/payments made for prior period sales (34,647) (21,623)
Ending balance 62,817 35,934
Trade Allowances    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 12,035 3,743
Provision related to current period sales 19,077 15,685
Provision related to prior period sales (400) (298)
Credits/payments made for current period sales (9,097) (5,496)
Credits/payments made for prior period sales (5,282) (3,107)
Ending balance 16,333 10,527
Rebates, Chargebacks and Discounts    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 32,064 20,915
Provision related to current period sales 78,051 53,078
Provision related to prior period sales (836) (841)
Credits/payments made for current period sales (40,547) (34,771)
Credits/payments made for prior period sales (27,028) (16,722)
Ending balance 41,704 21,659
Product Returns    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 1,887 859
Provision related to current period sales 491 1,259
Credits/payments made for current period sales   (21)
Credits/payments made for prior period sales (40) (24)
Ending balance 2,338 2,073
Other Incentives    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 2,107 1,681
Provision related to current period sales 9,234 6,768
Provision related to prior period sales (69) (82)
Credits/payments made for current period sales (6,533) (4,922)
Credits/payments made for prior period sales (2,297) (1,770)
Ending balance $ 2,442 $ 1,675