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Debt - Long-Term Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) - USD ($)
 3 Months Ended 9 Months Ended
Dec. 06, 2012
Sep. 30, 2018
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Debt Disclosure [Line Items]          
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   $ 83,384,000 $ 83,384,000   $ 92,403,000
Interest expense, non-cash     1,687,000 $ 1,736,000  
CPPIB          
Debt Disclosure [Line Items]          
Maximum repayment of future revenue and receivables   94,100,000 94,100,000    
Repayment under agreement   5,300,000 15,000,000    
Future minimum repayment under agreement   5,500,000 5,500,000    
BioPharma Debt          
Debt Disclosure [Line Items]          
Amount received at the closing of the agreement $ 100,000,000        
Maximum repayment of future revenue and receivables 150,000,000        
Royalty-Bearing Debt          
Debt Disclosure [Line Items]          
Fair value of embedded derivative liability $ 14,600,000        
Gain (loss) on change in fair value of derivative liabilities     0 0  
Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount   $ 83,400,000 83,400,000   $ 92,400,000
Royalty-Bearing Debt | Cash          
Debt Disclosure [Line Items]          
Interest expense, contractual coupon interest     4,300,000 4,800,000  
Royalty-Bearing Debt | Non Cash          
Debt Disclosure [Line Items]          
Interest expense, non-cash     $ 1,500,000 $ 1,600,000