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Summarize Activity of the Net Product Revenue Allowance and Reserve Categories (Detail) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance $ 48,093 $ 27,198
Provision related to current period sales 175,167 124,571
Provision related to prior period sales (1,565) (1,220)
Credits/payments made for current period sales (106,961) (82,300)
Credits/payments made for prior period sales (43,617) (21,623)
Ending balance 71,117 46,626
Trade Allowances    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 12,035 3,743
Provision related to current period sales 30,814 24,780
Provision related to prior period sales (660) (297)
Credits/payments made for current period sales (15,908) (11,061)
Credits/payments made for prior period sales (11,657) (3,107)
Ending balance 14,624 14,058
Rebates, Chargebacks and Discounts    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 32,064 20,915
Provision related to current period sales 128,905 87,499
Provision related to prior period sales (836) (841)
Credits/payments made for current period sales (76,015) (62,014)
Credits/payments made for prior period sales (29,594) (16,722)
Ending balance 54,524 28,837
Product Returns    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 1,887 859
Provision related to current period sales 812 1,496
Credits/payments made for current period sales   (391)
Credits/payments made for prior period sales (69) (24)
Ending balance 2,630 1,940
Other Incentives    
Valuation and Qualifying Accounts Disclosure [Line Items]    
Beginning balance 2,107 1,681
Provision related to current period sales 14,636 10,796
Provision related to prior period sales (69) (82)
Credits/payments made for current period sales (15,038) (8,834)
Credits/payments made for prior period sales (2,297) (1,770)
Ending balance $ (661) $ 1,791