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Commitments and Contingencies - Additional Information (Detail) |  |  |  |  |  | 1 Months Ended | 12 Months Ended |  |  |  |  |  |
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Jul. 01, 2019 USD ($) | Jan. 26, 2019 USD ($) ft² | May 08, 2013 ft² | Dec. 15, 2012 ft² | Dec. 06, 2011 ft² | Jun. 30, 2015 ft² | Jan. 31, 2015 ft² | Apr. 30, 2014 ft² | Jan. 31, 2014 ft² | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Feb. 05, 2019 ft² | Dec. 31, 2018 EUR (€) | Dec. 31, 2018 GBP (£) | Dec. 15, 2016 ft² | Nov. 01, 2013 ft² | Sep. 30, 2011 ft² | Jul. 01, 2011 ft²
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease, rental expense | $ |  |  |  |  |  |  |  |  |  | $ 800,000 | $ 600,000 | $ 600,000 |  |  |  |  |  |  |
Potential payable amount over the agreement terms based on minimum purchase obligation | $ |  |  |  |  |  |  |  |  |  | 53,000,000 |  |  |  |  |  |  |  |  |
Further Indication for AMR101 | Marketing Approval In Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  |  |  | 9,600,000 |  |  |  |  | £ 7,500,000 |  |  |  |
Further Indication for AMR101 | Potential Marketing Approval 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  |  |  | 6,400,000 |  |  |  |  | 5,000,000 |  |  |  |
Further Indication for AMR101 | Potential Marketing Approval 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  |  |  | 6,400,000 |  |  |  |  | 5,000,000 |  |  |  |
Further Indication for AMR101 | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  |  |  | $ 12,700,000 |  |  |  |  | £ 10,000,000 |  |  |  |
Dublin |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 270 | 320 |
Operating lease, expiration date |  |  |  |  |  |  |  |  |  | Oct. 31, 2019 |  |  |  |  |  |  |  |  |
Operating lease, renewal option |  |  |  |  |  |  |  |  |  | 1 year |  |  |  |  |  |  |  |  |
Operating lease, monthly rent |  |  |  |  |  |  |  |  |  | $ 4,900 |  |  |  | € 4,200 |  |  |  |  |
Lease termination notice period |  |  |  |  |  |  |  |  |  | 3 months |  |  |  |  |  |  |  |  |
Bedminster |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 732 |  |  | 9,747
Operating lease, expiration date |  |  |  |  |  |  |  |  |  | Apr. 30, 2019 |  |  |  |  |  |  |  |  |
Additional office space leased (in square feet) |  |  | 10,883 | 2,601 | 2,142 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Square feet vacated in exchange for reduction on future rent payments |  |  |  |  |  |  |  | 2,000 | 2,142 |  |  |  |  |  |  |  |  |  |
Bedminster | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease, expiration date |  | Jun. 30, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional office space leased (in square feet) |  | 5,988 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Monthly rent payment | $ |  | $ 14,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Bedminster | Sublease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease, expiration date |  |  |  |  |  |  |  |  |  | Sep. 30, 2017 |  |  |  |  |  |  |  |  |
Additional office space leased under sublease (in square feet) |  |  |  |  |  | 2,500 | 4,700 |  |  |  |  |  |  |  |  |  |  |  |
Additional sublease with third party, ceased date |  |  |  |  |  |  |  |  |  | Mar. 31, 2018 |  |  |  |  |  |  |  |  |
Bridgewater | Scenario Forecast |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Monthly rent payment | $ | $ 141,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease agreement term | 11 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease commencement date | Jul. 01, 2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Bridgewater | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Office space lease area (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  | 67,747 |  |  |  |  |  |

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- Definition Term of lessee's operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 3 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=77888426&loc=SL77918673-209980 + Details
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