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Significant Accounting Policies - Additional Information (Detail) | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2018 USD ($) Segment Customer | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Jan. 01, 2018 USD ($) | Jan. 20, 2017 USD ($) | Dec. 31, 2012 USD ($)
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Accumulated deficit | $ (1,388,532,000) | $ (1,271,869,000) |  |  |  |
Trade receivables, credit period | 30 days |  |  |  |  |
U.S. federal corporate tax rate | 21.00% | 34.00% |  |  |  |
Gain on change in fair value of derivative liabilities |  |  | $ 8,170,000 |  |  |
Number of operating segments | Segment | 1 |  |  |  |  |
Minimum |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Trade receivables, credit period | 30 days |  |  |  |  |
Maximum |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Trade receivables, credit period | 60 days |  |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  |  |  |  | $ 150,000,000
Fair value of embedded derivative liability | $ 0 | $ 0 |  |  |  |
Gain on change in fair value of derivative liabilities | $ 0 | $ 0 |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt | Minimum |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Derivative liability fair value assumption, coupon rate | 5.40% | 5.80% |  |  |  |
Derivative liability fair value assumptions, market yields | 6.70% | 10.20% |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt | Maximum |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Derivative liability fair value assumption, coupon rate | 10.80% | 10.80% |  |  |  |
Derivative liability fair value assumptions, market yields | 15.80% | 18.40% |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt | Measurement Input, Expected Term | Minimum |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Derivative liability fair value assumptions, term | 1 year 3 months 18 days | 2 years 3 months 18 days |  |  |  |
Embedded Derivative Financial Instruments | BioPharma Debt | Measurement Input, Expected Term | Maximum |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Derivative liability fair value assumptions, term | 4 years | 4 years 3 months 18 days |  |  |  |
Gross Product Sales | Customer Concentration Risk |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Number of customers | Customer | 3 |  |  |  |  |
Customer A | Gross Product Sales | Customer Concentration Risk |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Concentration risk percentage | 31.00% | 27.00% |  |  |  |
Customer A | Accounts Receivable | Customer Concentration Risk |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Concentration risk percentage | 26.00% | 27.00% |  |  |  |
Customer B | Gross Product Sales | Customer Concentration Risk |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Concentration risk percentage | 30.00% | 33.00% |  |  |  |
Customer B | Accounts Receivable | Customer Concentration Risk |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Concentration risk percentage | 24.00% | 21.00% |  |  |  |
Customer C | Gross Product Sales | Customer Concentration Risk |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Concentration risk percentage | 27.00% | 28.00% |  |  |  |
Customer C | Accounts Receivable | Customer Concentration Risk |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Concentration risk percentage | 39.00% | 41.00% |  |  |  |
2017 Notes |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Aggregate principal amount of notes | $ 30,000,000 |  |  |  |  |
Convertible senior notes, discount | 1,200,000 |  |  |  |  |
Convertible Debt | 2017 Notes |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Convertible senior notes, discount | $ 0 | $ 1,000,000 |  |  | $ 1,200,000 |
Difference between Revenue Guidance in Effect before and after Topic 606 | Accounting Standards Update 2014-09 |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |
Accumulated deficit |  |  |  | $ 200,000 |  |

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