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Development, Commercialization and Supply Agreement - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended
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Sep. 30, 2017 USD ($) | Mar. 31, 2016 USD ($) | Feb. 28, 2015 USD ($) | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Sep. 30, 2018 USD ($) | Dec. 31, 2018 USD ($) Item | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized related to upfront and milestone payments |  |  |  |  |  |  |  |  |  |  |  |  | $ 843,000 |  |
Licenses revenue |  |  |  | $ 77,330,000 | $ 55,323,000 | $ 52,643,000 | $ 43,919,000 | $ 53,866,000 | $ 47,360,000 | $ 45,241,000 | $ 34,637,000 |  | 229,214,000 | $ 181,104,000 | $ 130,084,000
Deferred revenue |  |  |  | 20,710,000 |  |  |  | 19,054,000 |  |  |  |  | 20,710,000 | 19,054,000 |
Licensing Revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  |  |  |  |  | 843,000 | 1,279,000 | $ 1,118,000
Mochida | In-licenses | Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,700,000 |  |
Eddingpharm | Out-licenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable up-front received |  |  | $ 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Number of indications of the regulatory milestone events relating to the submission and approval | Item |  |  |  |  |  |  |  |  |  |  |  |  | 3 |  |
Amounts to be received upon achievement of the regulatory milestone events |  |  |  |  |  |  |  |  |  |  |  |  | $ 33,000,000 |  |
Sales-based milestone event payment |  |  |  |  |  |  |  |  |  |  |  |  | 120,000,000 |  |
Revenue recognized related to upfront and milestone payments |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 | 1,200,000 |
Deferred revenue |  |  |  | 13,200,000 |  |  |  | 12,900,000 |  |  |  |  | 13,200,000 | 12,900,000 |
Eddingpharm | Out-licenses | Licensing Revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  |  |  |  |  | 2,800,000 | 3,100,000 |
Eddingpharm | Out-licenses | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone |  |  |  |  |  |  |  |  |  |  |  |  | 153,000,000 |  |
Amounts to be received upon achievement of the regulatory milestone events |  |  |  |  |  |  |  |  |  |  |  |  | 15,000,000 |  |
Sales-based milestone event payment |  |  |  |  |  |  |  |  |  |  |  |  | 50,000,000 |  |
Eddingpharm | Out-licenses | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amounts to be received upon achievement of the regulatory milestone events |  |  |  |  |  |  |  |  |  |  |  |  | 2,000,000 |  |
Sales-based milestone event payment |  |  |  |  |  |  |  |  |  |  |  |  | 5,000,000 |  |
Eddingpharm | Out-licenses | Clinical Trial Application |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable milestone payment |  | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Biologix FZCo | Out-licenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognition period of non-refundable up-front payment |  | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |
HLS | Out-licenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable up-front received | $ 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable milestone payment | $ 2,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized related to upfront and milestone payments |  |  |  |  |  |  |  |  |  |  |  |  | 600,000 | 100,000 |
Deferred revenue |  |  |  | $ 6,600,000 |  |  |  | $ 4,900,000 |  |  |  |  | 6,600,000 | 4,900,000 |
Non-refundable up-front received period | 6 months |  |  |  |  |  |  |  |  |  |  |  |  |  |
HLS | Out-licenses | Other Receivables |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable milestone payment |  |  |  |  |  |  |  |  |  |  |  | $ 2,500,000 |  |  |
HLS | Out-licenses | Licensing Revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  |  |  |  |  | $ 900,000 | $ 100,000 |
HLS | Out-licenses | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone | $ 57,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |

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