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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Reconciliation of Total Amounts of Unrecognized Tax Benefits

The following is a reconciliation of the total amounts of unrecognized tax benefits for the years ended December 31, 2018, 2017 and 2016:

In thousands			2018				2017				2016
Beginning uncertain tax benefits			$	1,734			$	1,633			$	1,550
Prior year—increases				296				—				—
Prior year—decreases				(762	)			(20	)			—
Current year—increases				5,547				121				83
Ending uncertain tax benefits			$	6,815			$	1,734			$	1,633

Jurisdictions the Company Remains Subject to Tax Examinations

The Company files income tax returns in the United States, Ireland and United Kingdom, or UK. The Company remains subject to tax examinations in the following jurisdictions as of December 31, 2018:

Jurisdiction			Tax Years
United States—Federal			2015-2018
United States—State			2012-2018
Ireland			2014-2018
United Kingdom			2017-2018

Components of Loss from Operations Before Taxes

The components of loss from operations before taxes were as follows for the years ended December 31, 2018, 2017 and 2016:

In thousands			2018				2017				2016
United States			$	(13,583	)		$	(2,075	)		$	(8,115	)
Ireland and United Kingdom				(102,766	)			(52,743	)			(68,266	)
			$	(116,349	)		$	(54,818	)		$	(76,381	)

Benefit from Income Taxes

The provision for income taxes shown in the accompanying consolidated statements of operations consists of the following for fiscal 2018, 2017 and 2016:

In thousands		2018				2017				2016
Current:
United States—Federal		$	4			$	1,769			$	1,033
United States—State			92				196				138
Total current		$	96			$	1,965			$	1,171
Deferred:
United States—Federal			(1,968	)			5,760				(4,001	)
United States—State			(1,325	)			(487	)			(334	)
Ireland and United Kingdom			(5,435	)			(16,306	)			(143	)
Change in valuation allowance			8,728				22,115				13,276
Total deferred		$	—			$	11,082			$	8,798
Provision for income taxes		$	96			$	13,047			$	9,969

Difference between Benefit from Income Taxes and Amount Computed by Applying Statutory Income Tax Rate to Income Before Taxes

The provision for income taxes differs from the amount computed by applying the statutory income tax rate to income before taxes due to the following for fiscal 2018, 2017 and 2016:

In thousands		2018				2017				2016
Benefits from taxes at statutory rate		$	(29,087	)		$	(13,698	)		$	(19,039	)
Rate differential			9,796				3,071				4,667
Change in valuation reserves			8,728				22,115				13,276
Derivative liabilities			337				—				(668	)
Nondeductible employee compensation			3,058				1,668				1,164
Stock option/RSU windfall			(7,684	)			(1,182	)			—
Research and development credits			(1,438	)			(1,177	)			(1,689	)
Tax return to provision adjustments			6,736				5,788				4,524
U.S. rate change—tax reform			—				7,398				—
Cumulative translation adjustment			5,711				(12,554	)			7,385
Permanent and other			(404	)			1,635				(1,573	)
Non-deductible interest expense			267				(17	)			1,922
Tax reserves			4,956				—				—
Long-term debt from royalty-bearing instrument			(880	)			—				—
Provision for income taxes		$	96			$	13,047			$	9,969

Income Tax Effect of Each Type of Temporary Difference Comprising Net Deferred Tax Asset

The income tax effect of each type of temporary difference comprising the net deferred tax asset as of December 31, 2018 and 2017 is as follows:

In thousands			December 31, 2018				December 31, 2017
Deferred tax assets:
Net operating losses			$	119,355			$	110,715
Stock-based compensation				8,113				12,446
Tax credits				7,816				6,378
Other reserves and accrued liabilities				6,344				3,587
Gross deferred tax assets				141,628				133,126
Less: valuation allowance				(140,117	)			(131,389	)
Total deferred tax assets				1,511				1,737
Deferred tax liabilities:
Depreciation and amortization				(1,011	)			(1,145	)
Other liabilities				(500	)			(592	)
Total deferred tax liabilities				(1,511	)			(1,737	)
Net deferred tax assets			$	—			$	—

Valuation Allowance

The following table reflects the activity in the valuation allowance for the years ended December 31, 2018 and 2017:

In thousands		2018				2017
Beginning valuation allowance		$	131,389			$	109,274
Increase as reflected in income tax expense			13,609				11,466
Cumulative translation adjustment			(4,881	)			10,649
Ending valuation allowance		$	140,117			$	131,389

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