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Nature of Business and Basis of Presentation - Additional Information (Detail)
1 Months Ended 12 Months Ended
Jan. 20, 2017
USD ($)
Sep. 30, 2018
Employee
Dec. 31, 2018
USD ($)
shares
Patient
Employee
Segment
Dec. 31, 2017
USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]        
REDUCE-IT study, number of patients enrolled and randomized | Patient     8,179  
Number of operating segments | Segment     1  
Total current assets     $ 377,997,000 $ 153,270,000
Cash and cash equivalents     249,227,000 73,637,000
Accounts receivable, net     66,523,000 45,318,000
Inventory, net     57,802,000 $ 30,260,000
Other debt outstanding     $ 0  
Convertible Debt | 2017 Notes        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]        
Convertible senior notes, principal amount $ 30,000,000      
Convertible senior notes, due date 2047      
Convertible senior notes, stated interest rate 3.50%      
Convertible senior notes, total ADS into which the debt is exchangeable | shares     0  
Convertible senior notes, repurchase price at option of the issuer 100.00%      
Sales Representatives and Managers        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]        
Number of sales professionals | Employee   170 440  
Sales Representatives        
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]        
Number of sales professionals | Employee     400