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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Total revenue, net $ 229,214 $ 181,104 $ 130,084
Less: Cost of goods sold 54,543 44,952 34,363
Gross margin 174,671 136,152 95,721
Operating expenses:      
Selling, general and administrative 226,996 134,549 111,372
Research and development 55,900 47,158 49,975
Total operating expenses 282,896 181,707 161,347
Operating loss (108,225) (45,555) (65,626)
Gain on change in fair value of derivative liabilities     8,170
Interest expense (8,872) (9,766) (18,677)
Interest income 1,074 429 234
Other (expense) income, net (326) 74 (482)
Loss from operations before taxes (116,349) (54,818) (76,381)
Provision for income taxes (96) (13,047) (9,969)
Net loss $ (116,445) $ (67,865) $ (86,350)
Loss per share:      
Basic $ (0.39) $ (0.25) $ (0.41)
Diluted $ (0.39) $ (0.25) $ (0.41)
Weighted average shares outstanding:      
Basic 297,237 270,652 211,874
Diluted 297,237 270,652 211,874
Product Revenue, Net      
Total revenue, net $ 228,371 $ 179,825 $ 128,966
Licensing Revenue      
Total revenue, net $ 843 $ 1,279 $ 1,118