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Summarize Activity of the Net Product Revenue Allowance and Reserve Categories (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	$ 48,093	$ 27,198
Provision related to current period sales	258,274	178,531
Provision related to prior period sales	(1,914)	(1,075)
Credits/payments made for current period sales	(197,366)	(132,385)
Credits/payments made for prior period sales	(41,843)	(24,176)
Ending balance	65,244	48,093
Trade Allowances
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	12,035	3,743
Provision related to current period sales	46,002	35,067
Provision related to prior period sales		(323)
Credits/payments made for current period sales	(29,202)	(23,087)
Credits/payments made for prior period sales	(9,340)	(3,365)
Ending balance	19,495	12,035
Rebates, Chargebacks and Discounts
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	32,064	20,915
Provision related to current period sales	190,329	126,903
Provision related to prior period sales	(1,845)	(682)
Credits/payments made for current period sales	(148,857)	(96,181)
Credits/payments made for prior period sales	(30,057)	(18,891)
Ending balance	41,634	32,064
Product Returns
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	1,887	859
Provision related to current period sales	1,211	1,480
Credits/payments made for current period sales		(344)
Credits/payments made for prior period sales	(150)	(108)
Ending balance	2,948	1,887
Other Incentives
Valuation And Qualifying Accounts Disclosure [Line Items]
Beginning balance	2,107	1,681
Provision related to current period sales	20,732	15,081
Provision related to prior period sales	(69)	(70)
Credits/payments made for current period sales	(19,307)	(12,773)
Credits/payments made for prior period sales	(2,296)	(1,812)
Ending balance	$ 1,167	$ 2,107