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Development, Commercialization and Supply Agreement - Additional Information (Detail)	1 Months Ended			3 Months Ended								9 Months Ended	12 Months Ended
	Sep. 30, 2017 USD ($)	Mar. 31, 2016 USD ($)	Feb. 28, 2015 USD ($)	Dec. 31, 2018 USD ($)	Sep. 30, 2018 USD ($)	Jun. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Sep. 30, 2017 USD ($)	Jun. 30, 2017 USD ($)	Mar. 31, 2017 USD ($)	Sep. 30, 2018 USD ($)	Dec. 31, 2018 USD ($) Item	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)
License And Collaboration Agreements [Line Items]
Revenue recognized related to upfront and milestone payments													$ 843,000
Licenses revenue				$ 77,330,000	$ 55,323,000	$ 52,643,000	$ 43,919,000	$ 53,866,000	$ 47,360,000	$ 45,241,000	$ 34,637,000		229,214,000	$ 181,104,000	$ 130,084,000
Deferred revenue				20,710,000				19,054,000					20,710,000	19,054,000
Licensing Revenue
License And Collaboration Agreements [Line Items]
Licenses revenue													843,000	1,279,000	$ 1,118,000
Mochida | In-licenses | Research and Development Expense
License And Collaboration Agreements [Line Items]
Upfront payment													$ 2,700,000
Eddingpharm | Out-licenses
License And Collaboration Agreements [Line Items]
Non-refundable up-front received			$ 15,000,000
Number of indications of the regulatory milestone events relating to the submission and approval | Item													3
Amounts to be received upon achievement of the regulatory milestone events													$ 33,000,000
Sales-based milestone event payment													120,000,000
Revenue recognized related to upfront and milestone payments													100,000	1,200,000
Deferred revenue				13,200,000				12,900,000					13,200,000	12,900,000
Eddingpharm | Out-licenses | Licensing Revenue
License And Collaboration Agreements [Line Items]
Licenses revenue													2,800,000	3,100,000
Eddingpharm | Out-licenses | Maximum
License And Collaboration Agreements [Line Items]
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone													153,000,000
Amounts to be received upon achievement of the regulatory milestone events													15,000,000
Sales-based milestone event payment													50,000,000
Eddingpharm | Out-licenses | Minimum
License And Collaboration Agreements [Line Items]
Amounts to be received upon achievement of the regulatory milestone events													2,000,000
Sales-based milestone event payment													5,000,000
Eddingpharm | Out-licenses | Clinical Trial Application
License And Collaboration Agreements [Line Items]
Non-refundable milestone payment		$ 1,000,000
Biologix FZCo | Out-licenses
License And Collaboration Agreements [Line Items]
Revenue recognition period of non-refundable up-front payment		10 years
HLS | Out-licenses
License And Collaboration Agreements [Line Items]
Non-refundable up-front received	$ 5,000,000
Non-refundable milestone payment	$ 2,500,000
Revenue recognized related to upfront and milestone payments													600,000	100,000
Deferred revenue				$ 6,600,000				$ 4,900,000					6,600,000	4,900,000
Non-refundable up-front received period	6 months
HLS | Out-licenses | Other Receivables
License And Collaboration Agreements [Line Items]
Non-refundable milestone payment												$ 2,500,000
HLS | Out-licenses | Licensing Revenue
License And Collaboration Agreements [Line Items]
Licenses revenue													$ 900,000	$ 100,000
HLS | Out-licenses | Maximum
License And Collaboration Agreements [Line Items]
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone	$ 57,500,000

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