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Condensed Consolidated Statement of Changes in Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Preferred Shares | Common Shares | Treasury Stock | Additional Paid-in Capital | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ (65,100) | $ 24,364 | $ 208,768 | $ (4,229) | $ 977,866 | $ (1,271,869)
Balance (in shares) at Dec. 31, 2017 |  | 328,184,640 | 272,719,044 | (1,697,033) |  |
Balance (Cumulative-effect adjustment) | Accounting Standards Update 2014-09 | (218) |  |  |  |  | (218)
Balance at Jan. 01, 2018 | (65,318) | $ 24,364 | $ 208,768 | $ (4,229) | 977,866 | (1,272,087)
Balance (in shares) at Jan. 01, 2018 |  | 328,184,640 | 272,719,044 | (1,697,033) |  |
Balance at Dec. 31, 2017 | (65,100) | $ 24,364 | $ 208,768 | $ (4,229) | 977,866 | (1,271,869)
Balance (in shares) at Dec. 31, 2017 |  | 328,184,640 | 272,719,044 | (1,697,033) |  |
Issuance of common stock, net of transaction costs | 70,007 |  | $ 14,635 |  | 55,372 |
Issuance of common stock, net of transaction costs (shares) |  |  | 20,616,438 |  |  |
Exercise of stock options | 1,548 |  | $ 541 |  | 1,007 |
Exercise of stock options (in shares) |  |  | 782,553 |  |  |
Vesting of restricted stock units | (2,553) |  | $ 1,302 | $ (2,553) | (1,302) |
Vesting of restricted stock units (in shares) |  |  | 1,838,380 | (675,242) |  |
Stock-based compensation | 3,754 |  |  |  | 3,754 |
Loss for the period | (24,095) |  |  |  |  | (24,095)
Balance at Mar. 31, 2018 | (16,657) | $ 24,364 | $ 225,246 | $ (6,782) | 1,036,697 | (1,296,182)
Balance (in shares) at Mar. 31, 2018 |  | 328,184,640 | 295,956,415 | (2,372,275) |  |
Balance at Dec. 31, 2017 | $ (65,100) | $ 24,364 | $ 208,768 | $ (4,229) | 977,866 | (1,271,869)
Balance (in shares) at Dec. 31, 2017 |  | 328,184,640 | 272,719,044 | (1,697,033) |  |
Exercise of stock options (in shares) | 956,232 |  |  |  |  |
Loss for the period | $ (58,305) |  |  |  |  |
Balance at Jun. 30, 2018 | (46,687) | $ 24,364 | $ 225,507 | $ (6,909) | 1,040,743 | (1,330,392)
Balance (in shares) at Jun. 30, 2018 |  | 328,184,640 | 296,348,903 | (2,413,527) |  |
Balance at Mar. 31, 2018 | (16,657) | $ 24,364 | $ 225,246 | $ (6,782) | 1,036,697 | (1,296,182)
Balance (in shares) at Mar. 31, 2018 |  | 328,184,640 | 295,956,415 | (2,372,275) |  |
Issuance of common stock under employee stock purchase plan | 423 |  | $ 85 |  | 338 |
Issuance of common stock under employee stock purchase plan (in shares) |  |  | 127,872 |  |  |
Exercise of stock options | 278 |  | $ 116 |  | 162 |
Exercise of stock options (in shares) |  |  | 173,679 |  |  |
Vesting of restricted stock units | (127) |  | $ 60 | $ (127) | (60) |
Vesting of restricted stock units (in shares) |  |  | 90,937 | (41,252) |  |
Stock-based compensation | 3,606 |  |  |  | 3,606 |
Loss for the period | (34,210) |  |  |  |  | (34,210)
Balance at Jun. 30, 2018 | (46,687) | $ 24,364 | $ 225,507 | $ (6,909) | 1,040,743 | (1,330,392)
Balance (in shares) at Jun. 30, 2018 |  | 328,184,640 | 296,348,903 | (2,413,527) |  |
Balance at Dec. 31, 2018 | 152,330 | $ 21,850 | $ 246,663 | $ (10,413) | 1,282,762 | (1,388,532)
Balance (in shares) at Dec. 31, 2018 |  | 289,317,460 | 329,110,863 | (3,260,850) |  |
Exercise of stock options | 15,456 |  | $ 2,496 |  | 12,960 |
Exercise of stock options (in shares) |  |  | 3,838,739 |  |  |
Vesting of restricted stock units | (9,080) |  | $ 929 | $ (9,080) | (929) |
Vesting of restricted stock units (in shares) |  |  | 1,416,124 | (526,708) |  |
Stock-based compensation | 6,596 |  |  |  | 6,596 |
Loss for the period | (24,431) |  |  |  |  | (24,431)
Balance at Mar. 31, 2019 | 140,871 | $ 21,850 | $ 250,088 | $ (19,493) | 1,301,389 | (1,412,963)
Balance (in shares) at Mar. 31, 2019 |  | 289,317,460 | 334,365,726 | (3,787,558) |  |
Balance at Dec. 31, 2018 | $ 152,330 | $ 21,850 | $ 246,663 | $ (10,413) | 1,282,762 | (1,388,532)
Balance (in shares) at Dec. 31, 2018 |  | 289,317,460 | 329,110,863 | (3,260,850) |  |
Exercise of stock options (in shares) | 4,458,143 |  |  |  |  |
Loss for the period | $ (26,251) |  |  |  |  |
Balance at Jun. 30, 2019 | 149,087 | $ 21,850 | $ 250,588 | $ (20,533) | 1,311,965 | (1,414,783)
Balance (in shares) at Jun. 30, 2019 |  | 289,317,460 | 335,149,425 | (3,841,615) |  |
Balance at Mar. 31, 2019 | 140,871 | $ 21,850 | $ 250,088 | $ (19,493) | 1,301,389 | (1,412,963)
Balance (in shares) at Mar. 31, 2019 |  | 289,317,460 | 334,365,726 | (3,787,558) |  |
Issuance of common stock under employee stock purchase plan | 837 |  | $ 30 |  | 807 |
Issuance of common stock under employee stock purchase plan (in shares) |  |  | 47,358 |  |  |
Exercise of stock options | 1,888 |  | $ 396 |  | 1,492 |
Exercise of stock options (in shares) |  |  | 619,404 |  |  |
Vesting of restricted stock units | (1,040) |  | $ 74 | $ (1,040) | (74) |
Vesting of restricted stock units (in shares) |  |  | 116,937 | (54,057) |  |
Stock-based compensation | 8,351 |  |  |  | 8,351 |
Loss for the period | (1,820) |  |  |  |  | (1,820)
Balance at Jun. 30, 2019 | $ 149,087 | $ 21,850 | $ 250,588 | $ (20,533) | $ 1,311,965 | $ (1,414,783)
Balance (in shares) at Jun. 30, 2019 |  | 289,317,460 | 335,149,425 | (3,841,615) |  |

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