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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Preferred Shares | Common Shares | Treasury Stock | Additional Paid-in Capital | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2016 | $ (9,058) | $ 24,364 | $ 207,166 | $ (1,498) | $ 964,914 | $ (1,204,004)
Balance (in shares) at Dec. 31, 2016 |  | 328,184,640 | 270,183,201 | (819,505) |  |
Exercise of stock options | 638 |  | $ 229 |  | 409 |
Exercise of stock options (in shares) |  |  | 356,656 |  |  |
Vesting of restricted stock units | (2,767) |  | $ 1,373 | $ (2,731) | (1,409) |
Vesting of restricted stock units (in shares) |  |  | 2,179,187 | (877,528) |  |
Stock-based compensation | 13,952 |  |  |  | 13,952 |
Loss for the period | (67,865) |  |  |  |  | (67,865)
Balance at Dec. 31, 2017 | (65,100) | $ 24,364 | $ 208,768 | $ (4,229) | 977,866 | (1,271,869)
Balance (in shares) at Dec. 31, 2017 |  | 328,184,640 | 272,719,044 | (1,697,033) |  |
Balance (Cumulative-effect adjustment) | Accounting Standards Update 2014-09 | (218) |  |  |  |  | (218)
Balance at Jan. 01, 2018 | (65,318) | $ 24,364 | $ 208,768 | $ (4,229) | 977,866 | (1,272,087)
Balance (in shares) at Jan. 01, 2018 |  | 328,184,640 | 272,719,044 | (1,697,033) |  |
Balance at Dec. 31, 2017 | (65,100) | $ 24,364 | $ 208,768 | $ (4,229) | 977,866 | (1,271,869)
Balance (in shares) at Dec. 31, 2017 |  | 328,184,640 | 272,719,044 | (1,697,033) |  |
Issuance of common stock, net of transaction costs | 264,840 |  | $ 21,744 |  | 243,096 |
Issuance of common stock, net of transaction costs (shares) |  |  | 31,727,550 |  |  |
Issuance of common stock under employee stock purchase plan | 1,043 |  | $ 203 |  | 840 |
Issuance of common stock under employee stock purchase plan (in shares) |  |  | 312,257 |  |  |
Exchange of exchangeable senior notes, net of transaction costs | 29,369 |  | $ 5,011 |  | 24,358 |
Exchange of exchangeable senior notes, net of transaction costs (in shares) |  |  | 7,716,046 |  |  |
Conversion of Series A Convertible Preferred Stock, net | (39) | $ (2,514) | $ 2,514 |  | (39) |
Conversion of Series A Convertible Preferred Stock, net (in shares) |  | (38,867,180) | 3,886,718 |  |  |
Exercise of stock options | $ 26,402 |  | $ 5,309 |  | 21,093 |
Exercise of stock options (in shares) | 8,138,305 |  | 8,138,305 |  |  |
Vesting of restricted stock units | $ (6,184) |  | $ 3,114 | $ (6,184) | (3,114) |
Vesting of restricted stock units (in shares) |  |  | 4,610,943 | (1,563,817) |  |
Stock-based compensation | 18,662 |  |  |  | 18,662 |
Loss for the period | (116,445) |  |  |  |  | (116,445)
Balance at Dec. 31, 2018 | 152,330 | $ 21,850 | $ 246,663 | $ (10,413) | 1,282,762 | (1,388,532)
Balance (in shares) at Dec. 31, 2018 |  | 289,317,460 | 329,110,863 | (3,260,850) |  |
Issuance of common stock, net of transaction costs | 440,108 |  | $ 15,879 |  | 424,229 |
Issuance of common stock, net of transaction costs (shares) |  |  | 25,555,556 |  |  |
Issuance of common stock under employee stock purchase plan | 2,165 |  | $ 79 |  | 2,086 |
Issuance of common stock under employee stock purchase plan (in shares) |  |  | 123,031 |  |  |
Issuance of common stock for milestone payment | 6,216 |  | $ 173 |  | 6,043 |
Issuance of common stock for milestone payment (in shares) |  |  | 257,713 |  |  |
Exercise of stock options | $ 24,478 |  | $ 3,876 |  | 20,602 |
Exercise of stock options (in shares) | 5,997,919 |  | 5,997,919 |  |  |
Vesting of restricted stock units | $ (25,487) |  | $ 2,503 | $ (25,487) | (2,503) |
Vesting of restricted stock units (in shares) |  |  | 3,969,811 | (1,650,142) |  |
Stock-based compensation | 31,098 |  |  |  | 31,098 |
Loss for the period | (22,645) |  |  |  |  | (22,645)
Balance at Dec. 31, 2019 | $ 608,263 | $ 21,850 | $ 269,173 | $ (35,900) | $ 1,764,317 | $ (1,411,177)
Balance (in shares) at Dec. 31, 2019 |  | 289,317,460 | 365,014,893 | (4,910,992) |  |

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