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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($)
$ in Thousands
Total
Preferred Shares
Common Shares
Treasury Stock
Additional Paid-in Capital
Accumulated Deficit
Balance at Dec. 31, 2016 $ (9,058) $ 24,364 $ 207,166 $ (1,498) $ 964,914 $ (1,204,004)
Balance (in shares) at Dec. 31, 2016   328,184,640 270,183,201 (819,505)    
Exercise of stock options 638   $ 229   409  
Exercise of stock options (in shares)     356,656      
Vesting of restricted stock units (2,767)   $ 1,373 $ (2,731) (1,409)  
Vesting of restricted stock units (in shares)     2,179,187 (877,528)    
Stock-based compensation 13,952       13,952  
Loss for the period (67,865)         (67,865)
Balance at Dec. 31, 2017 (65,100) $ 24,364 $ 208,768 $ (4,229) 977,866 (1,271,869)
Balance (in shares) at Dec. 31, 2017   328,184,640 272,719,044 (1,697,033)    
Balance (Cumulative-effect adjustment) | Accounting Standards Update 2014-09 (218)         (218)
Balance at Jan. 01, 2018 (65,318) $ 24,364 $ 208,768 $ (4,229) 977,866 (1,272,087)
Balance (in shares) at Jan. 01, 2018   328,184,640 272,719,044 (1,697,033)    
Balance at Dec. 31, 2017 (65,100) $ 24,364 $ 208,768 $ (4,229) 977,866 (1,271,869)
Balance (in shares) at Dec. 31, 2017   328,184,640 272,719,044 (1,697,033)    
Issuance of common stock, net of transaction costs 264,840   $ 21,744   243,096  
Issuance of common stock, net of transaction costs (shares)     31,727,550      
Issuance of common stock under employee stock purchase plan 1,043   $ 203   840  
Issuance of common stock under employee stock purchase plan (in shares)     312,257      
Exchange of exchangeable senior notes, net of transaction costs 29,369   $ 5,011   24,358  
Exchange of exchangeable senior notes, net of transaction costs (in shares)     7,716,046      
Conversion of Series A Convertible Preferred Stock, net (39) $ (2,514) $ 2,514   (39)  
Conversion of Series A Convertible Preferred Stock, net (in shares)   (38,867,180) 3,886,718      
Exercise of stock options $ 26,402   $ 5,309   21,093  
Exercise of stock options (in shares) 8,138,305   8,138,305      
Vesting of restricted stock units $ (6,184)   $ 3,114 $ (6,184) (3,114)  
Vesting of restricted stock units (in shares)     4,610,943 (1,563,817)    
Stock-based compensation 18,662       18,662  
Loss for the period (116,445)         (116,445)
Balance at Dec. 31, 2018 152,330 $ 21,850 $ 246,663 $ (10,413) 1,282,762 (1,388,532)
Balance (in shares) at Dec. 31, 2018   289,317,460 329,110,863 (3,260,850)    
Issuance of common stock, net of transaction costs 440,108   $ 15,879   424,229  
Issuance of common stock, net of transaction costs (shares)     25,555,556      
Issuance of common stock under employee stock purchase plan 2,165   $ 79   2,086  
Issuance of common stock under employee stock purchase plan (in shares)     123,031      
Issuance of common stock for milestone payment 6,216   $ 173   6,043  
Issuance of common stock for milestone payment (in shares)     257,713      
Exercise of stock options $ 24,478   $ 3,876   20,602  
Exercise of stock options (in shares) 5,997,919   5,997,919      
Vesting of restricted stock units $ (25,487)   $ 2,503 $ (25,487) (2,503)  
Vesting of restricted stock units (in shares)     3,969,811 (1,650,142)    
Stock-based compensation 31,098       31,098  
Loss for the period (22,645)         (22,645)
Balance at Dec. 31, 2019 $ 608,263 $ 21,850 $ 269,173 $ (35,900) $ 1,764,317 $ (1,411,177)
Balance (in shares) at Dec. 31, 2019   289,317,460 365,014,893 (4,910,992)