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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Cumulative Effect, Period of Adoption, Adjustment | Preferred Shares | Common Shares | Treasury Stock | Additional Paid-in Capital | Accumulated Deficit | Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment
--- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ (65,100) |  | $ 24,364 | $ 208,768 | $ (4,229) | $ 977,866 | $ (1,271,869) |
Balance (Accounting Standards Update 2014-09) at Dec. 31, 2017 |  | $ (218) |  |  |  |  |  | $ (218)
Balance (in shares) at Dec. 31, 2017 |  |  | 328,184,640 | 272,719,044 | (1,697,033) |  |  |
Accounting Standards Update [Extensible List] |  |  |  |  |  |  | us-gaap:AccountingStandardsUpdate201409Member |
Balance at Dec. 31, 2017 | (65,318) |  | $ 24,364 | $ 208,768 | $ (4,229) | 977,866 | $ (1,272,087) |
Balance (in shares) at Dec. 31, 2017 |  |  | 328,184,640 | 272,719,044 | (1,697,033) |  |  |
Issuance of common stock, net of transaction costs | 264,840 |  |  | $ 21,744 |  | 243,096 |  |
Issuance of common stock, net of transaction costs (shares) |  |  |  | 31,727,550 |  |  |  |
Issuance of common stock under employee stock purchase plan | 1,043 |  |  | $ 203 |  | 840 |  |
Issuance of common stock under employee stock purchase plan (in shares) |  |  |  | 312,257 |  |  |  |
Exchange of exchangeable senior notes, net of transaction costs | 29,369 |  |  | $ 5,011 |  | 24,358 |  |
Exchange of exchangeable senior notes, net of transaction costs (in shares) |  |  |  | 7,716,046 |  |  |  |
Conversion of Series A Convertible Preferred Stock, net | (39) |  | $ (2,514) | $ 2,514 |  | (39) |  |
Conversion of Series A Convertible Preferred Stock, net (in shares) |  |  | (38,867,180) | 3,886,718 |  |  |  |
Exercise of stock options | 26,402 |  |  | $ 5,309 |  | 21,093 |  |
Exercise of stock options (in shares) |  |  |  | 8,138,305 |  |  |  |
Vesting of restricted stock units | (6,184) |  |  | $ 3,114 | $ (6,184) | (3,114) |  |
Vesting of restricted stock units (in shares) |  |  |  | 4,610,943 | (1,563,817) |  |  |
Stock-based compensation | 18,662 |  |  |  |  | 18,662 |  |
Loss for the period | (116,445) |  |  |  |  |  | (116,445) |
Balance at Dec. 31, 2018 | 152,330 |  | $ 21,850 | $ 246,663 | $ (10,413) | 1,282,762 | (1,388,532) |
Balance (in shares) at Dec. 31, 2018 |  |  | 289,317,460 | 329,110,863 | (3,260,850) |  |  |
Issuance of common stock, net of transaction costs | 440,108 |  |  | $ 15,879 |  | 424,229 |  |
Issuance of common stock, net of transaction costs (shares) |  |  |  | 25,555,556 |  |  |  |
Issuance of common stock under employee stock purchase plan | 2,165 |  |  | $ 79 |  | 2,086 |  |
Issuance of common stock under employee stock purchase plan (in shares) |  |  |  | 123,031 |  |  |  |
Issuance of common stock for milestone payment | 6,216 |  |  | $ 173 |  | 6,043 |  |
Issuance of common stock for milestone payment (in shares) |  |  |  | 257,713 |  |  |  |
Exercise of stock options | 24,478 |  |  | $ 3,876 |  | 20,602 |  |
Exercise of stock options (in shares) |  |  |  | 5,997,919 |  |  |  |
Vesting of restricted stock units | (25,487) |  |  | $ 2,503 | $ (25,487) | (2,503) |  |
Vesting of restricted stock units (in shares) |  |  |  | 3,969,811 | (1,650,142) |  |  |
Stock-based compensation | 31,098 |  |  |  |  | 31,098 |  |
Loss for the period | (22,645) |  |  |  |  |  | (22,645) |
Balance at Dec. 31, 2019 | 608,263 |  | $ 21,850 | $ 269,173 | $ (35,900) | 1,764,317 | (1,411,177) |
Balance (in shares) at Dec. 31, 2019 |  |  | 289,317,460 | 365,014,893 | (4,910,992) |  |  |
Issuance of common stock under employee stock purchase plan | 1,957 |  |  | $ 225 |  | 1,732 |  |
Issuance of common stock under employee stock purchase plan (in shares) |  |  |  | 347,153 |  |  |  |
Conversion of Series A Convertible Preferred Stock, net | (504) |  | $ (21,850) | $ 18,020 |  | 3,326 |  |
Conversion of Series A Convertible Preferred Stock, net (in shares) |  |  | (289,317,460) | 28,931,746 |  |  |  |
Exercise of stock options | $ 5,158 |  |  | $ 1,062 |  | 4,096 |  |
Exercise of stock options (in shares) | 1,623,000 |  |  | 1,623,460 |  |  |  |
Vesting of restricted stock units | $ (15,182) |  |  | $ 1,635 | $ (15,182) | (1,635) |  |
Vesting of restricted stock units (in shares) |  |  |  | 2,507,748 | (975,927) |  |  |
Stock-based compensation | 45,813 |  |  |  |  | 45,813 |  |
Loss for the period | (18,000) |  |  |  |  |  | (18,000) |
Balance at Dec. 31, 2020 | $ 627,505 |  |  | $ 290,115 | $ (51,082) | $ 1,817,649 | $ (1,429,177) |
Balance (in shares) at Dec. 31, 2020 |  |  |  | 398,425,000 | (5,886,919) |  |  |

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