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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net loss | $ (18,000) | $ (22,645) | $ (116,445)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization | 597 | 180 | 23
Amortization of investments | 1,602 |  |
Stock-based compensation | 45,813 | 30,917 | 18,806
Amortization of debt discount and debt issuance costs | 635 | 1,644 | 2,183
Amortization of intangible asset | 1,441 | 679 | 646
Changes in assets and liabilities: |  |  |
Accounts receivable, net | (38,144) | (49,907) | (21,205)
Inventory | (112,095) | (18,967) | (27,542)
Prepaid and other current assets | (17,636) | (10,366) | 510
Other long-term assets | 642 | (900) |
Interest receivable | (1,329) |  |
Accrued interest payable | (428) | (210) | (310)
Deferred revenue | (2,214) | 136 | 1,656
Accounts payable, accrued expenses and other current liabilities | 114,741 | 65,913 | 37,602
Other long-term liabilities | 2,629 | (5,840) | 9,373
Net cash used in operating activities | (21,746) | (9,366) | (94,703)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Sale and maturities of securities | 301,989 |  |
Purchases of securities | (678,700) |  |
Purchases of furniture, fixtures and equipment | (252) | (2,478) | (58)
Net cash used in investing activities | (376,963) | (2,478) | (58)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from issuance of common stock, net of transaction costs |  | 440,108 | 264,840
Proceeds from issuance of common stock under employee stock purchase plan | 1,957 | 2,165 | 1,043
Proceeds from exercise of stock options, net of transaction costs | 5,158 | 24,478 | 26,402
Payment of transaction costs for conversion of preferred stock | (504) |  | (39)
Payment on debt from royalty-bearing instrument | (50,336) | (31,652) | (14,690)
Transaction costs related to exchange of exchangeable senior notes |  |  | (121)
Taxes related to stock-based awards | (15,182) | (25,487) | (6,184)
Net cash (used in) provided by financing activities | (58,907) | 409,612 | 271,251
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | (457,616) | 397,768 | 176,490
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD | 648,495 | 250,727 | 74,237
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD | 190,879 | 648,495 | 250,727
Cash paid during the year for: |  |  |
Interest | 2,043 | 4,591 | 21,527
Income taxes | 207 | 67 | 850
Supplemental disclosure of non-cash transactions: |  |  |
Laxdale milestone |  | 8,457 |
Initial recognition of operating lease right-of-use asset |  | $ 8,995 |
Exchange of exchangeable senior notes into common stock |  |  | 29,490
Conversion of Series A Convertible Preferred Stock into common stock | $ 18,020 |  | $ 2,514

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