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Commitments and Contingencies - Additional Information (Detail) $ in Thousands | Jun. 30, 2021 USD ($) | Jun. 30, 2021 GBP (£) | Dec. 31, 2020 USD ($)
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Commitments And Contingencies Disclosure [Line Items] |  |  |
Potential payable amount over the agreement terms based on minimum purchase obligation | $ 213,000 |  |
Accrued expenses and other current liabilities | 226,545 |  | $ 198,641
Communication costs pertaining to marketing commitments | 7,900 |  |
Further Indication for AMR101 | Marketing Approval In Europe |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |
Potential aggregate stock or cash payment | £ |  | £ 7,500,000 |
Accrued expenses and other current liabilities | 12,000 |  |
Further Indication for AMR101 | Potential Marketing Approval 1 |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |
Aggregate stock or cash payment upon potential market approval | 6,900 | 5,000,000 |
Further Indication for AMR101 | Potential Marketing Approval 2 |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |
Aggregate stock or cash payment upon potential market approval | $ 6,900 | £ 5,000,000 |

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