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Stock Incentive Plans and Stock-Based Compensation - Stock-Based Compensation Expense Related to Option Awards (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | $ 36,938 | $ 45,813 | $ 30,917
Research and Development |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | 4,327 | 6,568 | 4,615
Selling, general and administrative |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | 32,305 | $ 39,245 | $ 26,302
Restructuring |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | $ 306 |  |

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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