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Income Taxes - Income Taxes Effect of Each Type of Temporary Difference Comprising Net Differed Tax Asset (Detail) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | --- | ---
Deferred tax assets: |  |  |
Net operating losses | $ 127,378 | $ 125,859 |
Stock-based compensation | 8,563 | 7,565 |
Tax credits | 15,803 | 14,690 |
Lease Liability | 2,348 | 2,219 |
Other reserves and accrued liabilities | 11,257 | 14,702 |
Gross deferred tax assets | 165,349 | 165,035 |
Less: valuation allowance | (160,295) | (160,841) | $ (137,976)
Total deferred tax assets | 5,054 | 4,194 |
Deferred tax liabilities: |  |  |
Depreciation and amortization | (3,404) | (2,399) |
Lease Asset | (1,639) | (1,784) |
Other liabilities | (11) | (11) |
Total deferred tax liabilities | $ (5,054) | $ (4,194) |

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