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Stock Incentive Plans and Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2021
Share-based Payment Arrangement [Abstract] |
Stock Option Activity | The following table summarizes all stock option activity for the year ended December 31, 2021:
In thousands (except per share amounts and years) |  | Number of Shares |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  | Aggregate Intrinsic Value |
Outstanding as of January 1, 2021 |  |  | 16,664 |  |  | $ | 8.00 |  |  |  |  |  |
Granted |  |  | 4,813 |  |  |  | 5.12 |  |  |  |  |  |
Forfeited |  |  | (1,481 | ) |  |  | 10.88 |  |  |  |  |  |
Expired |  |  | (299 | ) |  |  | 12.04 |  |  |  |  |  |
Exercised |  |  | (1,204 | ) |  |  | 2.43 |  |  |  |  |  |
Outstanding as of December 31, 2021 |  |  | 18,493 |  |  |  | 7.32 |  |  | 6.4 years |  | $ | 7,762 |
Exercisable as of December 31, 2021 |  |  | 12,487 |  |  |  | 6.81 |  |  | 5.2 years |  | $ | 7,744 |
Vested and expected to vest as of December 31, 2021 |  |  | 18,193 |  |  | $ | 7.30 |  |  | 6.3 years |  | $ | 7,761 |
Available for future grant as of December 31, 2021 |  |  | 13,229 |  |  |  |  |  |  |  |  |
Assumptions Used to Estimate Fair Value of Share-Based Payment Awards | For 2021, 2020, and 2019, the Company used the following assumptions to estimate the fair value of share-based payment awards:
|  | 2021 |  | 2020 |  | 2019
Risk-free interest rate |  | 0.53% - 1.36% |  | 0.33% - 1.74% |  | 1.55% - 2.95%
Expected dividend yield |  | 0.00% |  | 0.00% |  | 0.00%
Expected option life (years) |  | 6.25 |  | 6.25 |  | 6.25
Expected volatility |  | 96% - 99% |  | 84% - 99% |  | 92% - 94%
Restricted Stock Unit Activity | The following table presents the restricted stock unit activity for the years ended December 31, 2021 and 2020:
In thousands (except per share amounts) |  | Shares |  |  | Weighted Average Grant Date Fair Value |
Outstanding as of January 1, 2021 |  |  | 7,710 |  |  |  | 9.67 |
Granted |  |  | 7,725 |  |  |  | 5.07 |
Vested |  |  | (4,057 | ) |  |  | 5.98 |
Forfeited |  |  | (2,101 | ) |  |  | 8.57 |
Outstanding as of December 31, 2021 |  |  | 9,277 |  |  | $ | 7.70 |
Stock-Based Compensation Expense Related to Option Awards | The following table presents the stock-based compensation expense related to stock-based awards for the years ended December 31, 2021, 2020, and 2019:
In thousands |  | 2021 |  |  | 2020 |  |  | 2019 |
Research and development |  | $ | 4,327 |  |  | $ | 6,568 |  |  | $ | 4,615 |
Selling, general and administrative |  |  | 32,305 |  |  |  | 39,245 |  |  |  | 26,302 |
Restructuring |  |  | 306 |  |  |  | — |  |  |  | — |
Stock-based compensation expense |  | $ | 36,938 |  |  | $ | 45,813 |  |  | $ | 30,917 |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=122041274&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5047-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References No definition available. + Details
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