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Equity - Incentive Equity Awards - Summary of Equity Awards Activity (Detail) - USD ($) | 3 Months Ended
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Mar. 31, 2022 | Mar. 31, 2021
Stockholders Equity Note [Line Items] |  |  |
Common shares issued for stock option exercises |  | 10,602 | 783,320
Gross and net proceeds from stock option exercises |  | $ 30,000 | $ 2,059,000
Restricted Stock Units (RSUs) |  |  |
Stockholders Equity Note [Line Items] |  |  |
Common shares issued in settlement of RSUs and Performance Based RSUs vested |  | 493,381 | 940,977
Shares retained for settlement of employee tax obligations |  | 161,083 | 365,463
Performance-Based RSUs |  |  |
Stockholders Equity Note [Line Items] |  |  |
Common shares issued in settlement of RSUs and Performance Based RSUs vested | [1] |  | 1,506,428
Shares retained for settlement of employee tax obligations |  |  | 638,502
[1] | Performance-based RSUs vested in connection with the achievement of certain regulatory and sales performance conditions associated with the REDUCE-IT clinical trial and subsequent revenue growth. These performance-based RSUs have fully vested as of August 2021.

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