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Development, Commercialization and Supply Agreement - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |
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Jan. 31, 2022 USD ($) | Jan. 31, 2021 USD ($) | Feb. 29, 2020 USD ($) | Jan. 31, 2020 USD ($) | Sep. 30, 2018 USD ($) | Sep. 30, 2017 USD ($) | Mar. 31, 2016 USD ($) | Feb. 28, 2015 USD ($) | Jun. 30, 2022 USD ($) | Jun. 30, 2021 USD ($) | Jun. 30, 2022 USD ($) Item | Jun. 30, 2021 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2020 USD ($)
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized related to upfront and milestone payments |  |  |  |  |  |  |  |  |  |  | $ 701,000 | $ 662,000 |  |  |
Licenses revenue |  |  |  |  |  |  |  |  | $ 94,440,000 | $ 154,488,000 | 189,070,000 | 296,658,000 |  |  |
Deferred revenue |  |  |  |  |  |  |  |  | 16,008,000 | 17,970,000 | 16,008,000 | 17,970,000 | $ 16,709,000 |  | $ 18,632,000
Product Revenue, Net |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  | 93,796,000 | 153,773,000 | $ 187,782,000 | 295,156,000 |  |  |
Mochida Pharmaceutical Co., Ltd. | In-licenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestones payment | $ 1,000,000.0 | $ 1,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Mochida Pharmaceutical Co., Ltd. | In-licenses | Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,700,000 |
Edding | Out-licenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable up-front received |  |  |  |  |  |  |  | $ 15,000,000.0 |  |  |  |  |  |  |
Number of indications of the regulatory milestone events relating to the submission and approval | Item |  |  |  |  |  |  |  |  |  |  | 3 |  |  |  |
Amounts to be received upon achievement of the regulatory milestone events |  |  |  |  |  |  |  |  | 33,000,000.0 |  | $ 33,000,000.0 |  |  |  |
Sales-based milestone event payment |  |  |  |  |  |  |  |  | 120,000,000.0 |  | 120,000,000.0 |  |  |  |
Revenue recognized related to upfront and milestone payments |  |  |  |  |  |  |  |  |  |  | 300,000 | 600,000 |  |  |
Deferred revenue |  |  |  |  |  |  |  |  | 9,500,000 |  | 9,500,000 |  | 9,800,000 |  |
Edding | Out-licenses | Licensing Revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  |  |  | 7,400,000 |  | 7,100,000 |  |
Edding | Out-licenses | Product Revenue, Net |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  | 0 | 100,000 | 0 | 100,000 |  |  |
Edding | Out-licenses | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone |  |  |  |  |  |  |  |  | 153,000,000.0 |  | 153,000,000.0 |  |  |  |
Amounts to be received upon achievement of the regulatory milestone events |  |  |  |  |  |  |  |  | 15,000,000.0 |  | 15,000,000.0 |  |  |  |
Sales-based milestone event payment |  |  |  |  |  |  |  |  | 50,000,000.0 |  | 50,000,000.0 |  |  |  |
Edding | Out-licenses | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amounts to be received upon achievement of the regulatory milestone events |  |  |  |  |  |  |  |  | 2,000,000.0 |  | 2,000,000.0 |  |  |  |
Sales-based milestone event payment |  |  |  |  |  |  |  |  | 5,000,000.0 |  | 5,000,000.0 |  |  |  |
Edding | Out-licenses | Clinical Trial Application |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable milestone payment received |  |  |  |  |  |  | $ 1,000,000.0 |  |  |  |  |  |  |  |
Biologix FZCo | Out-licenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognition period of non-refundable up-front payment |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |
Biologix FZCo | Out-licenses | Product Revenue, Net |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  | 0 | 0 | 0 | 500,000 |  |  |
HLS | Out-licenses |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable up-front received |  |  |  |  |  | $ 5,000,000.0 |  |  |  |  |  |  |  |  |
Non-refundable milestone payment received |  |  | $ 2,500,000 | $ 3,800,000 | $ 2,500,000 |  |  |  |  |  |  |  |  |  |
Revenue recognized related to upfront and milestone payments |  |  |  |  |  |  |  |  |  |  | 300,000 | 600,000 |  |  |
Deferred revenue |  |  |  |  |  |  |  |  | 5,900,000 |  | 5,900,000 |  | 6,200,000 |  |
Non-refundable up-front received period |  |  |  |  |  | 6 months |  |  |  |  |  |  |  |  |
Non-refundable milestone payment received |  |  |  |  |  | $ 3,800,000 |  |  |  |  |  |  |  |  |
HLS | Out-licenses | Health Canada |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable milestone payment received |  |  |  |  |  | 2,500,000 |  |  |  |  |  |  |  |  |
HLS | Out-licenses | Licensing Revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  |  |  | 7,800,000 |  | $ 7,500,000 |  |
HLS | Out-licenses | Product Revenue, Net |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licenses revenue |  |  |  |  |  |  |  |  | $ 2,300,000 |  | $ 2,300,000 |  |  |  |
HLS | Out-licenses | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone |  |  |  |  |  | 50,000,000.0 |  |  |  |  |  |  |  |  |
HLS | Out-licenses | Achievement of REDUCE-IT Trial |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable milestone payment received |  |  |  |  |  | $ 2,500,000 |  |  |  |  |  |  |  |  |

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