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Commitments and Contingencies - Additional Information (Detail) $ in Thousands | Dec. 31, 2022 USD ($) | Dec. 31, 2022 GBP (£) | Jul. 13, 2022 GBP (£) | Dec. 31, 2021 USD ($) | Mar. 26, 2021 GBP (£)
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Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Potential payable amount over the agreement terms based on minimum purchase obligation | $ | $ 86,000 |  |  |  |
Accrued expenses and other current liabilities | $ | 192,678 |  |  | $ 253,111 |
Further Indication for AMR101 | Marketing Approval In Europe |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Potential aggregate stock or cash payment | £ |  |  |  |  | £ 7,500,000
Aggregate stock or cash payment upon potential market approval | £ |  |  | £ 7,500,000 |  |
Further Indication for AMR101 | Potential Marketing Approval 1 |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Aggregate stock or cash payment upon potential market approval | 6,000 | £ 5,000,000.0 |  |  |
Further Indication for AMR101 | Potential Marketing Approval 2 |  |  |  |  |
Commitments And Contingencies Disclosure [Line Items] |  |  |  |  |
Aggregate stock or cash payment upon potential market approval | $ 6,000 | £ 5,000,000.0 |  |  |

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