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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net (loss) income | $ (105,803) | $ 7,729 | $ (18,000)
Adjustments to reconcile net (loss) income to net cash used in operating activities: |  |  |
Depreciation and amortization | 551 | 587 | 597
Amortization of investments | 473 | 1,929 | 1,602
Stock-based compensation | 26,213 | 36,938 | 45,813
Amortization of debt discount and debt issuance costs |  |  | 635
Amortization of intangible asset | 2,545 | 2,270 | 1,441
Changes in assets and liabilities: |  |  |
Accounts receivable, net | 32,663 | (9,079) | (38,144)
Inventory | (36,422) | (167,066) | (112,095)
Prepaid and other current assets | 2,860 | 8,595 | (17,636)
Other long-term assets | (2) | (24) | 642
Interest receivable | 341 | 738 | (1,329)
Accrued interest payable |  |  | (428)
Deferred revenue | (1,363) | (1,923) | (2,214)
Accounts payable, accrued expenses and other current liabilities | (102,729) | 51,516 | 114,741
Other long-term liabilities | 581 | 1,253 | 2,629
Net cash used in operating activities | (180,092) | (66,537) | (21,746)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Sale and maturities of securities | 257,520 | 394,294 | 301,989
Purchases of securities | (81,633) | (290,195) | (678,700)
Investment in website development costs | (599) |  |
Disposal (purchases) of furniture, fixtures and equipment |  | 4 | (252)
Net cash provided by (used in) investing activities | 175,288 | 104,103 | (376,963)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from issuance of common stock under employee stock purchase plan | 605 | 1,650 | 1,957
Proceeds from exercise of stock options, net of transaction costs | 60 | 2,921 | 5,158
Payment of transaction costs for conversion of preferred stock |  |  | (504)
Payment on debt from royalty-bearing instrument |  |  | (50,336)
Taxes related to stock-based awards | (1,044) | (9,644) | (15,182)
Net cash used in financing activities | (379) | (5,073) | (58,907)
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH | (5,183) | 32,493 | (457,616)
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD | 223,372 | 190,879 | 648,495
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD | 218,189 | 223,372 | 190,879
Cash (paid) received during the year for: |  |  |
Interest |  |  | (2,043)
Income taxes | (1,782) | 3,656 | (207)
Supplemental disclosure of non-cash transactions: |  |  |
Laxdale milestone |  | $ 12,000 |
Shares issued in settlement of Laxdale milestone payment | 8,203 |  |
Initial recognition of operating lease right-of-use asset | $ 2,041 |  |
Conversion of Series A Convertible Preferred Stock into common stock |  |  | $ 18,020

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