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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Preferred Shares
Common Shares
Treasury Stock
Additional Paid-in Capital
Accumulated Deficit
Balance at Dec. 31, 2019 $ 608,263 $ 21,850 $ 269,173 $ (35,900) $ 1,764,317 $ (1,411,177)
Balance (in shares) at Dec. 31, 2019   289,317,460 365,014,893      
Balance, Treasury Shares (in shares) at Dec. 31, 2019       (4,910,992)    
Conversion of Series A Convertible Preferred Stock, net (504) $ (21,850) $ 18,020   3,326  
Conversion of Series A Convertible Preferred Stock, net (in shares)   (289,317,460) 28,931,746      
Issuance of common stock under employee stock purchase plan 1,957   $ 225   1,732  
Issuance of common stock under employee stock purchase plan (in shares)     347,153      
Exercise of stock options 5,158   $ 1,062   4,096  
Exercise of stock options (in shares)     1,623,460      
Vesting of restricted stock units (15,182)   $ 1,635 $ (15,182) (1,635)  
Vesting of restricted stock units (in shares)     2,507,748 (975,927)    
Stock-based compensation 45,813       45,813  
Income (loss) for the period (18,000)         (18,000)
Balance at Dec. 31, 2020 627,505   $ 290,115 $ (51,082) 1,817,649 (1,429,177)
Balance (in shares) at Dec. 31, 2020     398,425,000      
Balance, Treasury Shares (in shares) at Dec. 31, 2020       (5,886,919)    
Issuance of common stock under employee stock purchase plan 1,650   $ 275   1,375  
Issuance of common stock under employee stock purchase plan (in shares)     399,286      
Exercise of stock options $ 2,921   $ 827   2,094  
Exercise of stock options (in shares) 1,203,845   1,203,845      
Vesting of restricted stock units $ (9,644)   $ 2,810 $ (9,644) (2,810)  
Vesting of restricted stock units (in shares)     4,056,644 (1,599,848)    
Stock-based compensation 36,938       36,938  
Income (loss) for the period 7,729         7,729
Balance at Dec. 31, 2021 $ 667,099   $ 294,027 $ (60,726) 1,855,246 (1,421,448)
Balance (in shares) at Dec. 31, 2021     404,084,775      
Balance, Treasury Shares (in shares) at Dec. 31, 2021 7,486,767     (7,486,767)    
Issuance of common stock under employee stock purchase plan $ 605   $ 283   322  
Issuance of common stock under employee stock purchase plan (in shares)     456,696      
Issuance of common stock for milestone payment 8,203   $ 3,461   4,742  
Issuance of common stock for milestone payment (in shares)     5,817,942      
Exercise of stock options $ 60   $ 21   39  
Exercise of stock options (in shares) 33,303   33,303      
Vesting of restricted stock units $ (1,044)   $ 1,210 $ (1,044) (1,210)  
Vesting of restricted stock units (in shares)     1,940,371 (500,064)    
Stock-based compensation 26,213       26,213  
Income (loss) for the period (105,803)         (105,803)
Balance at Dec. 31, 2022 $ 595,333   $ 299,002 $ (61,770) $ 1,885,352 $ (1,527,251)
Balance (in shares) at Dec. 31, 2022     412,333,087      
Balance, Treasury Shares (in shares) at Dec. 31, 2022 7,986,831     (7,986,831)