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Condensed Consolidated Statement of Changes in Stockholders' Equity - USD ($) $ in Thousands | Total | Common Shares | Treasury Shares | Additional Paid-in Capital | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Balance, Treasury Shares (in shares) |  |  | (7,486,767) |  |
Balance at Dec. 31, 2021 | $ 667,099 | $ 294,027 | $ (60,726) | $ 1,855,246 | $ (1,421,448)
Balance (in shares) at Dec. 31, 2021 |  | 404,084,775 |  |  |
Exercise of stock options | 30 | $ 6 |  | 24 |
Exercise of stock options (in shares) |  | 10,602 |  |  |
Vesting of restricted stock units | (535) | $ 331 | $ (535) | (331) |
Vesting of restricted stock units (in shares) |  | 493,381 | (161,083) |  |
Stock-based compensation | 6,078 |  |  | 6,078 |
Loss for the period | (31,563) |  |  |  | (31,563)
Balance at Mar. 31, 2022 | 641,109 | $ 294,364 | $ (61,261) | 1,861,017 | (1,453,011)
Balance (in shares) at Mar. 31, 2022 |  | 404,588,758 |  |  |
Balance at Dec. 31, 2021 | $ 667,099 | $ 294,027 | (60,726) | 1,855,246 | (1,421,448)
Balance (in shares) at Dec. 31, 2021 |  | 404,084,775 |  |  |
Exercise of stock options (in shares) | 33,303 |  |  |  |
Loss for the period | $ (106,659) |  |  |  |
Balance at Sep. 30, 2022 | 587,827 | $ 298,596 | $ (61,585) | 1,878,923 | (1,528,107)
Balance (in shares) at Sep. 30, 2022 |  | 411,660,040 |  |  |
Balance, Treasury Shares (in shares) |  |  | (7,647,850) |  |
Balance at Mar. 31, 2022 | 641,109 | $ 294,364 | $ (61,261) | 1,861,017 | (1,453,011)
Balance (in shares) at Mar. 31, 2022 |  | 404,588,758 |  |  |
Issuance of common stock under employee stock purchase plan | 383 | $ 166 |  | 217 |
Issuance of common stock under employee stock purchase plan (in shares) |  | 265,214 |  |  |
Exercise of stock options | 19 | $ 9 |  | 10 |
Exercise of stock options (in shares) |  | 14,645 |  |  |
Vesting of restricted stock units | (158) | $ 120 | $ (158) | (120) |
Vesting of restricted stock units (in shares) |  | 187,835 | (61,551) |  |
Stock-based compensation | 8,646 |  |  | 8,646 |
Loss for the period | (69,956) |  |  |  | (69,956)
Balance at Jun. 30, 2022 | 580,043 | $ 294,659 | $ (61,419) | 1,869,770 | (1,522,967)
Balance (in shares) at Jun. 30, 2022 |  | 405,056,452 |  |  |
Balance, Treasury Shares (in shares) |  |  | (7,709,401) |  |
Issuance of common stock for milestone payment | 8,203 | $ 3,461 |  | 4,742 |
Issuance of common stock for milestone payment (in shares) |  | 5,817,942 |  |  |
Exercise of stock options | 10 | $ 5 |  | 5 |
Exercise of stock options (in shares) |  | 8,056 |  |  |
Vesting of restricted stock units | (166) | $ 471 | $ (166) | (471) |
Vesting of restricted stock units (in shares) |  | 777,590 | (121,684) |  |
Stock-based compensation | 4,877 |  |  | 4,877 |
Loss for the period | (5,140) |  |  |  | (5,140)
Balance at Sep. 30, 2022 | $ 587,827 | $ 298,596 | $ (61,585) | 1,878,923 | (1,528,107)
Balance (in shares) at Sep. 30, 2022 |  | 411,660,040 |  |  |
Balance, Treasury Shares (in shares) |  |  | (7,831,085) |  |
Balance, Treasury Shares (in shares) | 7,986,831 |  | (7,986,831) |  |
Balance at Dec. 31, 2022 | $ 595,333 | $ 299,002 | $ (61,770) | 1,885,352 | (1,527,251)
Balance (in shares) at Dec. 31, 2022 |  | 412,333,087 |  |  |
Exercise of stock options | 1,871 | $ 744 |  | 1,127 |
Exercise of stock options (in shares) |  | 1,232,263 |  |  |
Vesting of restricted stock units | (1,507) | $ 1,539 | $ (1,507) | (1,539) |
Vesting of restricted stock units (in shares) |  | 2,514,948 | (827,523) |  |
Stock-based compensation | 5,556 |  |  | 5,556 |
Loss for the period | (16,460) |  |  |  | (16,460)
Balance at Mar. 31, 2023 | 584,793 | $ 301,285 | $ (63,277) | 1,890,496 | (1,543,711)
Balance (in shares) at Mar. 31, 2023 |  | 416,080,298 |  |  |
Balance at Dec. 31, 2022 | $ 595,333 | $ 299,002 | (61,770) | 1,885,352 | (1,527,251)
Balance (in shares) at Dec. 31, 2022 |  | 412,333,087 |  |  |
Exercise of stock options (in shares) | 1,239,763 |  |  |  |
Loss for the period | $ (53,331) |  |  |  |
Balance at Sep. 30, 2023 | 553,148 | $ 302,318 | $ (63,743) | 1,895,155 | (1,580,582)
Balance (in shares) at Sep. 30, 2023 |  | 417,744,958 |  |  |
Balance, Treasury Shares (in shares) |  |  | (8,814,354) |  |
Balance at Mar. 31, 2023 | 584,793 | $ 301,285 | $ (63,277) | 1,890,496 | (1,543,711)
Balance (in shares) at Mar. 31, 2023 |  | 416,080,298 |  |  |
Issuance of common stock under employee stock purchase plan | 240 | $ 127 |  | 113 |
Issuance of common stock under employee stock purchase plan (in shares) |  | 205,861 |  |  |
Exercise of stock options | 7 | $ 4 |  | 3 |
Exercise of stock options (in shares) |  | 6,000 |  |  |
Vesting of restricted stock units | (187) | $ 490 | $ (187) | (490) |
Vesting of restricted stock units (in shares) |  | 800,242 | (144,240) |  |
Stock-based compensation | 1,835 |  |  | 1,835 |
Loss for the period | (17,560) |  |  |  | (17,560)
Balance at Jun. 30, 2023 | 569,128 | $ 301,906 | $ (63,464) | 1,891,957 | (1,561,271)
Balance (in shares) at Jun. 30, 2023 |  | 417,092,401 |  |  |
Balance, Treasury Shares (in shares) |  |  | (8,958,594) |  |
Issuance of common stock under employee stock purchase plan | 2 | $ 1 |  | 1 |
Exercise of stock options (in shares) |  | 1,500 |  |  |
Vesting of restricted stock units | (279) | $ 411 | $ (279) | (411) |
Vesting of restricted stock units (in shares) |  | 651,057 | (235,344) |  |
Stock-based compensation | 3,608 |  |  | 3,608 |
Loss for the period | (19,311) |  |  |  | (19,311)
Balance at Sep. 30, 2023 | $ 553,148 | $ 302,318 | $ (63,743) | $ 1,895,155 | $ (1,580,582)
Balance (in shares) at Sep. 30, 2023 |  | 417,744,958 |  |  |
Balance, Treasury Shares (in shares) | 9,193,938 |  | (9,193,938) |  |

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