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Condensed Consolidated Statement of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Shares
Treasury Shares
Additional Paid-in Capital
Accumulated Deficit
Balance, Treasury Shares (in shares)     (7,486,767)    
Balance at Dec. 31, 2021 $ 667,099 $ 294,027 $ (60,726) $ 1,855,246 $ (1,421,448)
Balance (in shares) at Dec. 31, 2021   404,084,775      
Exercise of stock options 30 $ 6   24  
Exercise of stock options (in shares)   10,602      
Vesting of restricted stock units (535) $ 331 $ (535) (331)  
Vesting of restricted stock units (in shares)   493,381 (161,083)    
Stock-based compensation 6,078     6,078  
Loss for the period (31,563)       (31,563)
Balance at Mar. 31, 2022 641,109 $ 294,364 $ (61,261) 1,861,017 (1,453,011)
Balance (in shares) at Mar. 31, 2022   404,588,758      
Balance at Dec. 31, 2021 $ 667,099 $ 294,027 (60,726) 1,855,246 (1,421,448)
Balance (in shares) at Dec. 31, 2021   404,084,775      
Exercise of stock options (in shares) 33,303        
Loss for the period $ (106,659)        
Balance at Sep. 30, 2022 587,827 $ 298,596 $ (61,585) 1,878,923 (1,528,107)
Balance (in shares) at Sep. 30, 2022   411,660,040      
Balance, Treasury Shares (in shares)     (7,647,850)    
Balance at Mar. 31, 2022 641,109 $ 294,364 $ (61,261) 1,861,017 (1,453,011)
Balance (in shares) at Mar. 31, 2022   404,588,758      
Issuance of common stock under employee stock purchase plan 383 $ 166   217  
Issuance of common stock under employee stock purchase plan (in shares)   265,214      
Exercise of stock options 19 $ 9   10  
Exercise of stock options (in shares)   14,645      
Vesting of restricted stock units (158) $ 120 $ (158) (120)  
Vesting of restricted stock units (in shares)   187,835 (61,551)    
Stock-based compensation 8,646     8,646  
Loss for the period (69,956)       (69,956)
Balance at Jun. 30, 2022 580,043 $ 294,659 $ (61,419) 1,869,770 (1,522,967)
Balance (in shares) at Jun. 30, 2022   405,056,452      
Balance, Treasury Shares (in shares)     (7,709,401)    
Issuance of common stock for milestone payment 8,203 $ 3,461   4,742  
Issuance of common stock for milestone payment (in shares)   5,817,942      
Exercise of stock options 10 $ 5   5  
Exercise of stock options (in shares)   8,056      
Vesting of restricted stock units (166) $ 471 $ (166) (471)  
Vesting of restricted stock units (in shares)   777,590 (121,684)    
Stock-based compensation 4,877     4,877  
Loss for the period (5,140)       (5,140)
Balance at Sep. 30, 2022 $ 587,827 $ 298,596 $ (61,585) 1,878,923 (1,528,107)
Balance (in shares) at Sep. 30, 2022   411,660,040      
Balance, Treasury Shares (in shares)     (7,831,085)    
Balance, Treasury Shares (in shares) 7,986,831   (7,986,831)    
Balance at Dec. 31, 2022 $ 595,333 $ 299,002 $ (61,770) 1,885,352 (1,527,251)
Balance (in shares) at Dec. 31, 2022   412,333,087      
Exercise of stock options 1,871 $ 744   1,127  
Exercise of stock options (in shares)   1,232,263      
Vesting of restricted stock units (1,507) $ 1,539 $ (1,507) (1,539)  
Vesting of restricted stock units (in shares)   2,514,948 (827,523)    
Stock-based compensation 5,556     5,556  
Loss for the period (16,460)       (16,460)
Balance at Mar. 31, 2023 584,793 $ 301,285 $ (63,277) 1,890,496 (1,543,711)
Balance (in shares) at Mar. 31, 2023   416,080,298      
Balance at Dec. 31, 2022 $ 595,333 $ 299,002 (61,770) 1,885,352 (1,527,251)
Balance (in shares) at Dec. 31, 2022   412,333,087      
Exercise of stock options (in shares) 1,239,763        
Loss for the period $ (53,331)        
Balance at Sep. 30, 2023 553,148 $ 302,318 $ (63,743) 1,895,155 (1,580,582)
Balance (in shares) at Sep. 30, 2023   417,744,958      
Balance, Treasury Shares (in shares)     (8,814,354)    
Balance at Mar. 31, 2023 584,793 $ 301,285 $ (63,277) 1,890,496 (1,543,711)
Balance (in shares) at Mar. 31, 2023   416,080,298      
Issuance of common stock under employee stock purchase plan 240 $ 127   113  
Issuance of common stock under employee stock purchase plan (in shares)   205,861      
Exercise of stock options 7 $ 4   3  
Exercise of stock options (in shares)   6,000      
Vesting of restricted stock units (187) $ 490 $ (187) (490)  
Vesting of restricted stock units (in shares)   800,242 (144,240)    
Stock-based compensation 1,835     1,835  
Loss for the period (17,560)       (17,560)
Balance at Jun. 30, 2023 569,128 $ 301,906 $ (63,464) 1,891,957 (1,561,271)
Balance (in shares) at Jun. 30, 2023   417,092,401      
Balance, Treasury Shares (in shares)     (8,958,594)    
Issuance of common stock under employee stock purchase plan 2 $ 1   1  
Exercise of stock options (in shares)   1,500      
Vesting of restricted stock units (279) $ 411 $ (279) (411)  
Vesting of restricted stock units (in shares)   651,057 (235,344)    
Stock-based compensation 3,608     3,608  
Loss for the period (19,311)       (19,311)
Balance at Sep. 30, 2023 $ 553,148 $ 302,318 $ (63,743) $ 1,895,155 $ (1,580,582)
Balance (in shares) at Sep. 30, 2023   417,744,958      
Balance, Treasury Shares (in shares) 9,193,938   (9,193,938)