<SEC-DOCUMENT>0000899140-23-000032.txt : 20230111
<SEC-HEADER>0000899140-23-000032.hdr.sgml : 20230111
<ACCEPTANCE-DATETIME>20230110200425
ACCESSION NUMBER:		0000899140-23-000032
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20230111
DATE AS OF CHANGE:		20230110
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.
GROUP MEMBERS:		LOUIS STERLING III

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMARIN CORP PLC\UK
		CENTRAL INDEX KEY:			0000897448
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-52399
		FILM NUMBER:		23522345

	BUSINESS ADDRESS:	
		STREET 1:		SPACES SOUTH DOCKLANDS, BLOCK C
		STREET 2:		77 SIR JOHN ROGERSON'S QUAY
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60
		BUSINESS PHONE:		353 1 6699 020

	MAIL ADDRESS:	
		STREET 1:		SPACES SOUTH DOCKLANDS, BLOCK C
		STREET 2:		77 SIR JOHN ROGERSON'S QUAY
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMARIN PHARMACEUTICALS PLC
		DATE OF NAME CHANGE:	20000201

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ETHICAL HOLDINGS PLC
		DATE OF NAME CHANGE:	19930322

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>s58919650a.htm
<DESCRIPTION>SCHEDULE 13D/A, AMENDMENT #4
<TEXT>
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    <div style="text-align: center; margin-bottom: 12pt;"><font style="font-weight: bold;">UNITED STATES</font><br>
      <font style="font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font><br>
      Washington, D.C. 20549</div>
    <div style="text-align: center; font-weight: bold;">SCHEDULE 13D</div>
    <div><br>
    </div>
    <div style="text-align: center;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center;">(Amendment No. 4)*<br>
      <br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z2feacdeb4a4f437da0a17b801ed11a60" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">Amarin Corporation plc</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Name of Issuer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">Ordinary Shares, par value 50 pence per share</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Title of Class of Securities)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">023111206</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(CUSIP Number)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">Mark DiPaolo</div>
            <div style="text-align: center;">Senior Partner, General Counsel</div>
            <div style="text-align: center;">Sarissa Capital Management LP</div>
            <div style="text-align: center;">660 Steamboat Road</div>
            <div style="text-align: center;">Greenwich, CT 06830</div>
            <div style="text-align: center;">203-302-2330</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Name, Address and Telephone Number of Person<br>
              Authorized to Receive Notices and Communications)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">January 10, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Date of Event which Requires Filing of this Statement)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify; margin-bottom: 12pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e),
      13d-1(f) or 13d-1(g), check the following box. &#9744;</div>
    <div style="text-align: justify; margin-bottom: 12pt;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other
      parties to whom copies are to be sent.</div>
    <div>*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures
      provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that
      section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
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      <div><br>
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      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zbca1a10759a34f7c94f58f4096668728">

          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman', Times, serif;">Page <font style="font-size: 12pt;">2</font> of 9 Pages</div>
            </td>
          </tr>
          <tr>
            <td colspan="2" style="width: 100%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div> <br>
    </div>
    <table cellspacing="0" cellpadding="3" border="0" id="zd1d949ec13e040c380ebea5b79c7483e" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">1</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Sarissa Capital Management LP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">2</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div><br>
              (a)&#160; &#9744;</div>
            <div>(b)&#160; &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">3</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">4</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SOURCE OF FUNDS<br>
              <br>
              WC</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">5</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">6</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              Delaware</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">7</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">8</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED VOTING POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">9</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">10</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">11</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">12</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
            <div> <br>
            </div>
            <div> <br>
            </div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">13</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              6.24%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">14</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>PN</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
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          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman', Times, serif;">Page 3 of 9 Pages</div>
            </td>
          </tr>
          <tr>
            <td colspan="2" style="width: 100%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div> <br>
    </div>
    <table cellspacing="0" cellpadding="3" border="0" id="zef4567b32d0e446e870d52453ff4b383" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">1</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Alexander J. Denner, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">2</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div><br>
              (a)&#160; &#9744;</div>
            <div>(b)&#160; &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">3</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">4</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SOURCE OF FUNDS<br>
              <br>
              AF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">5</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">6</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              United States</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">7</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">8</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED VOTING POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">9</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">10</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">11</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">12</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
            <div> <br>
            </div>
            <div> <br>
            </div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">13</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              6.24%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">14</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>IN</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zbca1a10759a34f7c94f58f4096668728">

          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman', Times, serif;">Page 4 of 9 Pages</div>
            </td>
          </tr>
          <tr>
            <td colspan="2" style="width: 100%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <div> <br>
    </div>
    <table cellspacing="0" cellpadding="3" border="0" id="zd55892f938fc45398677b12b91442536" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">1</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Louis Sterling III</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">2</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div><br>
              (a)&#160; &#9744;</div>
            <div>(b)&#160; &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">3</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">4</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>SOURCE OF FUNDS<br>
              <br>
              PF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">5</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">6</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              United States</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 9%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">7</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE VOTING POWER<br>
              <br>
              117,772</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">8</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">9</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              117,772</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">10</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="2">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">11</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              117,772</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">12</div>
          </td>
          <td style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
            <div> <br>
            </div>
            <div> <br>
            </div>
          </td>
          <td style="width: 20%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#160;&#9744;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">13</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              Less than 1%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">14</div>
          </td>
          <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="4">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>IN</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zbca1a10759a34f7c94f58f4096668728">

          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman', Times, serif;">Page 5 of 9 Pages</div>
            </td>
          </tr>
          <tr>
            <td colspan="2" style="width: 100%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-bottom: 6pt;">This Amendment No. 4 to Schedule 13D (&#8220;Amendment No. 4&#8221;) relates to American Depositary Shares (&#8220;ADS(s)&#8221;), each ADS representing one ordinary share, par value 50 pence per share (the &#8220;Ordinary
      Shares&#8221;), issued by Amarin Corporation plc, a company incorporated under the laws of England and Wales (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on January 24, 2022
      (the &#8220;Initial Schedule 13D&#8221;), as amended by Amendment No. 1 to Schedule 13D filed on June 3, 2022, Amendment No. 2 to Schedule 13D filed on June 16, 2022, and Amendment No. 3 to Schedule 13D filed on October 11, 2022 (the Initial Schedule 13D as so
      amended, the &#8220;Schedule 13D&#8221;). All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D.</div>
    <div style="text-align: justify; margin-bottom: 6pt;">This Amendment No. 1 is being filed by Sarissa Capital Management LP, a Delaware limited partnership (&#8220;Sarissa Capital&#8221;) and Alexander J. Denner, Ph.D., a citizen of the United States of America
      (&#8220;Dr. Denner&#8221; and together with Sarissa Capital, the &#8220;Sarissa Reporting Persons&#8221;) and Louis Sterling III (&#8220;Mr. Sterling&#8221; and, together with the Sarissa Reporting Persons and Mr. Sterling, the &#8220;Reporting Persons&#8221;).</div>
    <div style="text-align: justify; margin-bottom: 6pt;">This Amendment No. 4 is being filed to amend Item 2, Item 3, Item 4, Item 5, Item 6 and Item 7 as follows:</div>
    <div style="text-align: justify; margin-bottom: 6pt;"><font style="font-weight: bold;">Item 2.</font>&#160; <font style="font-weight: bold;">Identity and Background.&#160;</font>Item 2 of the Schedule 13D is hereby amended to include the following:</div>
    <div style="text-align: justify; margin-bottom: 6pt;">
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zad6246d55f9d48a5a7a1148e054f1332">

          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: center;">(a)</div>
            </td>
            <td style="width: 93%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">This Schedule 13D is being filed by each of the Reporting Persons.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 93%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: center;">(b)</div>
            </td>
            <td style="width: 93%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">The principal business address of Mr. Sterling is 133 Gale Drive, Beverly Hills, CA 90211.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 93%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: center;">(c)</div>
            </td>
            <td style="width: 93%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">Mr. Sterling is a private investor.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 93%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: center;">(d)</div>
            </td>
            <td style="width: 93%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">Mr. Sterling has not, during the past five years, been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 93%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: center;">(e)</div>
            </td>
            <td style="width: 93%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">Mr. Sterling has not, during the past five years, been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a
                result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or a finding of any violation with respect
                to such laws.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
            <td style="width: 93%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%; vertical-align: top;">&#160;</td>
            <td style="width: 3%; vertical-align: top;">
              <div style="text-align: center;">(f)</div>
            </td>
            <td style="width: 93%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">Mr. Sterling is a citizen of the United States of America.</div>
            </td>
          </tr>

      </table>
    </div>
    <font style="font-weight: bold;">Item 3.&#160; Source or Amount of Funds or Other Consideration.&#160;</font>Item 3 of the Schedule 13D is hereby amended to include the following:
    <div style="text-align: justify; margin-top: 6pt; margin-bottom: 6pt;">The Sarissa Reporting Persons may be deemed to be the beneficial owner of, in the aggregate, 25,210,000 Shares. The aggregate purchase price of the Shares purchased by the Sarissa
      Reporting Persons as reported in Item 5(c) of this Amendment 4 is approximately $1,423,407. The source of funding for these purchases was the general working capital of the respective purchasers.</div>
    <div style="text-align: justify; margin-top: 6pt; margin-bottom: 6pt;">Mr. Sterling may be deemed to be the beneficial owner of 117,772 Shares. The aggregate purchase price of these Shares is approximately $378,752. The source of funding for these
      purchases was Mr. Sterling&#8217;s personal funds.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 25%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 25%; vertical-align: top; text-align: right;">&#160;Page 6 of 9 Pages<br>
            </td>
          </tr>
          <tr>
            <td colspan="3" style="width: 100%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
      <font style="font-weight: bold;"><font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"></font></font></div>
    <div style="margin-top: 6pt; margin-bottom: 6pt;"><font style="font-weight: bold;"> <br>
      </font></div>
    <div style="margin-top: 6pt; margin-bottom: 6pt;"><font style="font-weight: bold;">Item 4.&#160; Purpose of Transaction. </font>Item 4 of the Schedule 13D is hereby amended to include the following:</div>
    <div style="text-align: justify; margin-top: 6pt; margin-bottom: 6pt;">
      <div style="margin-top: 6pt; margin-bottom: 6pt;">On January 10, 2023,&#160;certain of the Sarissa Reporting Persons&#160;submitted a requisition notice to the Issuer to call a general meeting of shareholders to, among other things, appoint Patrice Bonfiglio,
        Paul Cohen, M.D., Mark DiPaolo Esq., Keith Horn, Odysseas Kostas M.D., Louis Sterling III and Diane Sullivan (collectively, the &#8220;Sarissa Nominees&#8221;) as directors of the Issuer. The requisition also included a proposal to remove Per Wold-Olsen as a
        director of the Issuer.&#160; A copy of the requisition notice is attached hereto as Exhibit 4 and is incorporated herein in its entirety. Sarissa Capital also issued a press release announcing the submission of the requisition. A copy of the press
        release is attached as Exhibit 5 hereto.</div>
    </div>
    <div style="text-align: justify; margin-top: 6pt; margin-bottom: 6pt;">Mr. Sterling acquired Shares for investment purposes. Mr. Sterling has agreed to serve as one of the Sarissa Nominees for election to the Issuer&#8217;s Board at the meeting of
      stockholders requisitioned by Sarissa Capital.</div>
    <div style="margin-top: 6pt; margin-bottom: 6pt;"><font style="font-weight: bold;">Item 5.&#160; Interest in Securities of the Issuer. </font>Item 5 of the Schedule 13D is hereby amended and restated as follows:</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="zdb6fb372ceb94debbeb49d503cb30eb9">

        <tr>
          <td style="width: 3%; vertical-align: top;">
            <div style="text-align: center;">(a)</div>
          </td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">The Sarissa Reporting Persons may be deemed to beneficially own, in the aggregate, 25,210,000 Shares representing approximately 6.24% of the
              outstanding Shares (the &#8220;Sarissa Shares&#8221;). Mr. Sterling may be deemed to beneficially own, in the aggregate, 117,772 Shares representing approximately 0.03% of the outstanding Shares (the &#8220;Sterling Shares&#8221;), including call options
              representing 53,500 Shares (as further described in Item 6). Percentages of the outstanding Shares are based upon the 403,828,955 Shares outstanding as of October 21, 2022, including 383,347,128 ADSs, and 20,481,827 Ordinary Shares, as set
              forth in the Form 10-Q of the Issuer filed with the SEC on October 27, 2022.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top;">
            <div style="text-align: center;">(b)</div>
          </td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">For purposes of this Schedule 13D:</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">All of the Shares which the Sarissa Reporting Persons may be deemed to beneficially own are held directly by the Sarissa Funds. Sarissa
              Capital, as the investment advisor to the Sarissa Funds, may be deemed to have the shared power to vote or direct the vote of (and the shared power to dispose or direct the disposition of) the Shares held directly by the Sarissa Funds. By
              virtue of his position as the Chief Investment Officer of Sarissa Capital and by virtue of his control of the ultimate general partner of Sarissa Capital, Dr. Denner may be deemed to have the shared power to vote or direct the vote of (and
              the shared power to dispose or direct the disposition of) the Shares held directly by the Sarissa Funds.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">Mr. Sterling has sole power to vote and dispose the Sterling Shares.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">The Sarissa Reporting Persons and Mr. Sterling may be deemed to have formed a group within the meaning of Rule 13d-5(b) under the Securities
              Exchange Act of 1934, as amended, and may be deemed to beneficially own, in the aggregate, 25,327,772 Shares representing approximately 6.27% of the outstanding Shares. The Sarissa Reporting Persons disclaim beneficial ownership of the
              Sterling Shares. Mr. Sterling disclaims beneficial ownership of the Sarissa Shares.<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top;">
            <div style="text-align: center;">(c)</div>
          </td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">On December 2, 2022, the Sarissa Funds acquired 40,000 Shares at $1.21 per Share in open market transactions, for an aggregate purchase price
              of $48,744.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">On December 5, 2022, the Sarissa Funds acquired 75,000 Shares at $1.17 per Share in open market transactions, for an aggregate purchase price
              of approximately $88,388.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">On December 6, 2022, the Sarissa Funds acquired 470,000 and 76,450 Shares at $1.17 and $1.16 per Share in open market transactions, for an
              aggregate purchase price of approximately $643,195.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">On December 7, 2022, the Sarissa Funds acquired 250,550 Shares at $1.17 per Share in open market transactions, for an aggregate purchase price
              of approximately $295,053.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">On December 8, 2022, the Sarissa Funds acquired 30,000 and 75,000 Shares at $1.16 and $1.15 per Share in open market transactions, for an
              aggregate purchase price of $122,049.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; text-align: center;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">On December 28, 2022, the Sarissa Funds acquired 90,000 Shares at $1.16 per Share in open market transactions, for an aggregate purchase price
              of $105,543.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
          <td style="width: 97%; vertical-align: top;">
            <div style="margin: 0px 0px 6pt; font-family: 'Times New Roman', Times, serif; text-align: justify;">On January 3, 2023, the Sarissa Funds acquired 103,000 Shares at $1.16 per Share in open market transactions, for an aggregate purchase price
              of approximately $120,436.<br>
            </div>
          </td>
        </tr>

    </table>
    <div> <br>
    </div>
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        <tr>
          <td style="width: 25%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
          </td>
          <td style="width: 25%; vertical-align: top; text-align: right;">&#160;Page 7 of 9 Pages<br>
          </td>
        </tr>
        <tr>
          <td colspan="3" style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;"><font style="font-weight: bold;">Item 6.&#160; Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer. </font>Item 6 of the Schedule 13D is hereby amended and
      restated as follows:</div>
    <div>
      <div style="margin-bottom: 6pt; font-style: italic;">Derivative&#160;Transactions</div>
    </div>
    <div style="text-align: justify; margin-bottom: 6pt;">The Reporting Persons may, from time to time, enter into and dispose of cash-settled equity swap, stock-settled equity swap, option or other&#160;derivative&#160;transactions with one or more counterparties
      that are based upon the value of the Shares, which transactions may be significant in amount. The profit, loss and/or return on such contracts may be wholly or partially dependent on the market value of the Shares. Mr. Sterling currently has
      purchased out-of-the-money call options representing 53,500 Shares through such contracts, which Shares are reflected in the amounts reported in Item 5.</div>
    <div style="text-align: justify; margin-bottom: 6pt; font-style: italic;">Joint Filing Agreement</div>
    <div style="text-align: justify; margin-bottom: 6pt;">On January 10, 2023, the Sarissa Capital, Dr. Denner and Mr. Sterling entered into a Joint Filing Agreement pursuant to which, among other things, the parties agreed to the joint filing on behalf of
      each of them of statements on Schedule 13D, and any amendments thereto, with respect to the securities of the Issuer to the extent required by applicable law. The Joint Filing Agreement is attached hereto as Exhibit 6 and is incorporated herein by
      reference.</div>
    <div style="text-align: justify; margin-bottom: 6pt;"><font style="font-weight: bold;">Item 7.&#160; Material to Be Filed as Exhibits. </font>Item 7 of the Schedule 13D is hereby amended to include the following:</div>
    <div style="margin-bottom: 6pt;">Exhibit 4 &#8211; Requisition Notice, January 10, 2023</div>
    <div style="margin-bottom: 6pt;">Exhibit 5 &#8211; Press Release, January 10, 2023</div>
    <div style="margin-bottom: 6pt;">Exhibit 6 &#8211; Joint Filing Agreement of the Reporting Persons</div>
    <div style="margin-bottom: 6pt;">Exhibit 7 &#8211; Power of Attorney Granted by Louis Sterling III in favor of Mark DiPaolo and Patrice Bonfiglio, January 10, 2023</div>
    <div style="margin-bottom: 6pt;"> <br>
    </div>
    <div style="margin-bottom: 6pt;"> <br>
    </div>
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    </div>
    <div style="margin-bottom: 18pt;">
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 12.5%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 12.5%; vertical-align: top; text-align: right;">&#160;Page 8 of 9 Pages</td>
          </tr>
          <tr>
            <td colspan="4" style="width: 100%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-align: center; margin-bottom: 18pt; font-weight: bold;">SIGNATURE</div>
    <div style="text-align: justify; text-indent: 36pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div>Dated: January 10, 2023</div>
    <div><br>
    </div>
    <div>SARISSA CAPITAL MANAGEMENT LP</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div>By:<font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font><u>/s/ Mark DiPaolo </u>_______________<br>
      <font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font>Name: Mark DiPaolo<br>
      <font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font>Title: Senior Partner, General Counsel</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><u>/s/ Alexander J. Denner &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160;</u> &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
      Alexander J. Denner</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><u>/s/ Louis Sterling III &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;</u><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt"> </font><br>
      Louis Sterling III</div>
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          <tr>
            <td style="width: 6.25%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 6.25%; vertical-align: top; text-align: right;">&#160;Page 9 of 9 Pages<br>
            </td>
          </tr>
          <tr>
            <td colspan="5" style="width: 100%; vertical-align: top;">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">INDEX TO EXHIBITS</div>
    <div><br>
    </div>
    <div style="margin-bottom: 6pt;">Exhibit 1 &#8211; Joint Filing Agreement of the Reporting Persons*</div>
    <div style="margin-bottom: 6pt;">Exhibit 2 &#8211; Press Release, June 15, 2022*</div>
    <div style="margin-bottom: 6pt;">Exhibit 3 &#8211; Press Release, October 11, 2022*</div>
    <div style="margin-bottom: 6pt;">Exhibit 4 &#8211; Requisition Notice, January 10, 2023</div>
    <div style="margin-bottom: 6pt;">Exhibit 5 &#8211; Press Release, January 10, 2023</div>
    <div style="margin-bottom: 6pt;">Exhibit 6 &#8211; Joint Filing Agreement of the Reporting Persons</div>
    <div style="margin-bottom: 6pt;">Exhibit 7 &#8211; Power of Attorney Granted by Louis Sterling III in favor of Mark DiPaolo and Patrice Bonfiglio, January 10, 2023</div>
    <div><br>
    </div>
    <div>*&#160; Previously filed.</div>
    <br>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>s58919650b.htm
<DESCRIPTION>EXHIBIT 4 - REQUISITION NOTICE, JANUARY 10, 2023
<TEXT>
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  <div style="text-align: right;">EXHIBIT 4<br>
  </div>
  <div> <br>
  </div>
  <div> <br>
  </div>
  <div>
    <div style="text-align: justify;">The Directors</div>
    <div style="text-align: justify;">Amarin Corporation plc</div>
    <div><br>
    </div>
    <div style="text-align: justify;">77 Sir John Rogerson&#8217;s Quay</div>
    <div style="text-align: justify;">Block C</div>
    <div style="text-align: justify;">Grand Canal Docklands</div>
    <div style="text-align: justify;">Dublin 2, Ireland</div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt;">January 10, 2023</div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt;">Dear Sirs</div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;">Request to convene a general meeting of Amarin Corporation plc (&#8220;Company&#8221;) and special notice of a resolution to remove a director of the Company, if applicable</div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt;">Pursuant to section 303 Companies Act 2006 (the &#8220;<font style="font-weight: bold;">Companies Act</font>&#8221;), the undersigned, being an authorized representative of the holders of not
      less than 5% of the paid-up share capital of the Company, as set forth on Appendix A attached hereto, which at the date of this requisition carries the right to vote at general meetings of the Company, requires you to call a general meeting of the
      Company not later than 21 days after you receive this requisition.</div>
    The business to be dealt with at the general meeting is to consider the proposals that (i) Patrice Bonfiglio, Paul Cohen, Mark DiPaolo, Keith L. Horn, Odysseas Kostas, Louis Sterling III, and Diane E. Sullivan each be appointed as a director of the
    Company, (ii) Per Wold-Olsen be removed from office as a director of the Company, and (iii) in the event any director is appointed after the Company&#8217;s receipt of this requisition, each such director be removed from office as a director of the Company.
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt;">At the general meeting it is intended to consider and, if thought fit, pass the following resolutions, which are being proposed as ordinary resolutions, and we give special notice
      pursuant to sections 168(2) and 312(1) of the Companies Act in relation to the resolutions to remove a director under section 168 of the Companies:</div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;">Ordinary resolution:</div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;">
      <table cellspacing="0" cellpadding="8" border="0" id="z4f6cd09da8c54b3a9fd78ccc1daa9ff6" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

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              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">1.</div>
            </td>
            <td style="width: 95%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">&#8220;THAT Per Wold-Olsen be removed from office as a director of the Company with immediate effect.&#8221;</div>
            </td>
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            <td style="width: 5%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">2.</div>
            </td>
            <td style="width: 95%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">&#8220;THAT in the event any director is appointed after the Company&#8217;s receipt of the general meeting requisition notice dated January 10, 2023, and
                prior to the general meeting, each such director be removed from office as a director of the Company with immediate effect.&#8221;</div>
            </td>
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            <td style="width: 5%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">3.</div>
            </td>
            <td style="width: 95%; vertical-align: top;">
              <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">&#8220;THAT each of Patrice Bonfiglio, Paul Cohen, Mark DiPaolo,
                Keith L. Horn, Odysseas Kostas, Louis Sterling III, and Diane E. Sullivan, having consented to act, be appointed as an additional director of the Company with immediate effect.&#8221;</div>
            </td>
          </tr>

      </table>
    </div>
    <div> </div>
    <div> </div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt;">The holders intend to solicit the holders of shares representing at least 67% of the voting power of shares entitled to vote on the election of directors in support of the
      foregoing director nominees.</div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt;">Attached hereto as Appendix B are signed notices by each Director Nominee of their willingness to be elected as a director of the Company.</div>
    <div><br>
    </div>
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    </div>
    <div style="text-align: justify; margin-top: 12pt; margin-bottom: 12pt; font-weight: bold;">Signed by:</div>
    <div>/s/ Mark DiPaolo<br>
    </div>
    <div style="text-align: justify;">&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.</div>
    <div style="text-align: justify; margin-bottom: 12pt; font-weight: bold;">Mark DiPaolo, as an authorized person</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt;"><br>
    </div>
    <div style="margin-bottom: 10pt;"><br>
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    <div> <br>
    </div>
    <div style="text-align: center;">
      <div style="margin-bottom: 12pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">APPENDIX A</div>
    </div>
    <div>
      <div style="text-align: center; margin-bottom: 12pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Members</div>
    </div>
    <div> <br>
    </div>
    <div><br>
      <br>
      <div><br>
      </div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div><br>
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      <div><br>
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        <div style="text-align: center; margin-bottom: 10pt; font-weight: bold;">APPENDIX B</div>
        <div style="text-align: center; margin-bottom: 10pt; font-weight: bold;">Notices of willingness to be elected as a director of the Company</div>
        <div style="margin-bottom: 10pt;"><br>
        </div>
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      </div>
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<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>3
<FILENAME>s58919650c.htm
<DESCRIPTION>EXHIBIT 5 - PRESS RELEASE, JANUARY 10, 2023
<TEXT>
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  <div style="text-align: right;">EXHIBIT 5<br>
  </div>
  <div> <br>
  </div>
  <div>
    <div style="font-style: italic; text-align: center;">SARISSA CAPITAL SUBMITS NOTICE TO CALL A SPECIAL MEETING OF AMARIN SHAREHOLDERS TO</div>
    <div style="text-align: center; margin-bottom: 8pt; font-style: italic;">ADD DIRECTORS AND REMOVE CHAIRMAN PER WOLD-OLSEN</div>
    <div style="text-align: center; margin-bottom: 8pt; font-style: italic;">Sarissa believes current board lacks any remaining credibility for representing shareholders</div>
    <div style="text-align: center; margin-bottom: 8pt; font-style: italic;">Sarissa is astonished that Amarin board refuses to add shareholder representatives</div>
    <div style="margin-bottom: 8pt;">Greenwich, CT, January 10, 2023 &#8211; Sarissa Capital Management LP (&#8220;Sarissa&#8221;) today made the following statement on Amarin Corporation plc (NASDAQ: AMRN):</div>
    <div style="margin-bottom: 8pt;">At the last shareholder meeting, the shareholders, the owners of the company, loudly expressed their lack of faith in the board and management. Sarissa sought to place shareholder representatives on the board and
      engaged with the company in what turned out to be months of simply lip service by the board, led by its Chairman Per Wold-Olsen. Despite Sarissa having a track record of creating significant shareholder value in healthcare companies, including those
      with cardiovascular drugs such as The Medicines Company, Amarin&#8217;s board rejected adding any shareholder representatives to the board in favor of their own candidates, including today&#8217;s addition of a board candidate without any input from Sarissa,
      Amarin&#8217;s largest shareholder.</div>
    <div style="margin-bottom: 8pt;">Amarin&#8217;s acknowledgement of its need for board refreshment is a positive step in recognizing the company&#8217;s many mishaps and the board&#8217;s own entrenchment. However, after months of back and forth, it is clear to us that
      this board refreshment process was a charade led by Chairman Per Wold-Olsen.</div>
    <div style="margin-bottom: 8pt;">Sarissa is astounded by Amarin&#8217;s blatant disregard for shareholders. The board&#8217;s actions epitomize poor governance. We believe that they do not understand a board&#8217;s mission and duties to shareholders, the owners of the
      company. We can only conclude that Amarin&#8217;s board does not seek real change and instead wants to remain entrenched at the expense of shareholders.</div>
    <div style="margin-bottom: 8pt;">Sarissa has submitted notice to Amarin under UK law to call a special meeting of shareholders to add 7 directors to the board and to remove Chairman Per Wold-Olsen from the board. In the event that the Amarin board
      attempts the contemptible act of continuing to entrench themselves by filling any of the vacancies on the board, takes any other actions in violation of their fiduciary duties or interferes with Sarissa&#8217;s exercise of its shareholder rights, Sarissa
      will initiate immediate legal action to hold all directors (including those added to the board) personally accountable to the fullest extent of the law. Such an act by the board would be the ultimate betrayal to shareholders. Sarissa will also seek
      to remove those directors appointed by the board in order to create the vacancies necessary to add Sarissa&#8217;s nominees to the board. We are asking all shareholders to remain engaged and voice their opinions by voting at the special meeting.</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zd015d2207b3746cb8ada565efddff8e8" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000; margin-bottom: 8pt;">

        <tr>
          <td style="width: 72pt; vertical-align: top; align: right;">Contact:</td>
          <td style="width: auto; vertical-align: top;">
            <div>Jean Puong<br>
              Sarissa Capital Management LP<br>
              <u>info@sarissacap.com</u></div>
          </td>
        </tr>

    </table>
    <div style="text-indent: -72pt; margin-left: 72pt; margin-bottom: 8pt;"> <br>
    </div>
    <div style="text-align: center; text-indent: -72pt; margin-left: 72pt; margin-bottom: 8pt;">###</div>
    <div style="margin: 0px 0px 8pt 0px; text-align: center;"><br>
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    </div>
    <div style="text-align: center; margin-bottom: 8pt; font-style: italic;">
      <div style="margin: 0px 0px 8pt 0px;">CERTAIN INFORMATION CONCERNING THE PARTICIPANTS </div>
    </div>
    <div style="margin-bottom: 12pt;">Sarissa Capital Management LP (&#8220;Sarissa Capital&#8221;), together with the other participants named herein (collectively, &#8220;Sarissa&#8221;), intends to file a preliminary proxy statement and accompanying proxy card with the
      Securities and Exchange Commission (&#8220;SEC&#8221;) to be used to solicit votes for the election of its slate of highly-qualified nominees as directors of Amarin Corporation plc (NASDAQ: AMRN) (the &#8220;Company&#8221;), at a special meeting of shareholders of the
      Company. SARISSA STRONGLY ADVISES ALL SHAREHOLDERS OF THE COMPANY TO READ THE PROXY STATEMENT AND OTHER PROXY MATERIALS AS THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION. SUCH PROXY MATERIALS WILL BE AVAILABLE AT NO CHARGE ON
      THE SEC&#8217;S WEB SITE AT HTTP://WWW.SEC.GOV. IN ADDITION, THE PARTICIPANTS IN THIS PROXY SOLICITATION WILL PROVIDE COPIES OF THE PROXY STATEMENT WITHOUT CHARGE, WHEN AVAILABLE, UPON REQUEST. REQUESTS FOR COPIES SHOULD BE DIRECTED TO THE PARTICIPANTS&#8217;
      PROXY SOLICITOR, THE IDENTITY AND CONTACT INFORMATION FOR WHICH WILL BE SET FORTH IN THE PROXY STATEMENT THAT WILL BE MADE AVAILABLE TO SHAREHOLDERS.</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt;">The participants in the proxy solicitation are anticipated to include Sarissa Capital, Sarissa Capital Offshore Master Fund LP (&#8220;Offshore&#8221;), Sarissa Capital Master Fund II LP (&#8220;Master II&#8221;), Sarissa
      Capital Athena Offshore Fund Ltd (&#8220;Athena&#8221;), Sarissa Capital Catapult Fund LLC (&#8220;Catapult&#8221;), Sarissa Capital Hawkeye Fund LP (&#8220;Hawkeye&#8221;), ISP Fund LP (&#8220;ISP&#8221;), Atom Master Fund LP (&#8220;Atom&#8221;), Sarissa Capital Management GP LLC (&#8220;Management GP&#8221;), Sarissa
      Capital Offshore Fund GP LLC (&#8220;Offshore GP&#8221;), Sarissa Capital Fund GP LP (&#8220;Fund GP LP&#8221;), Sarissa Capital Fund GP LLC (&#8220;Fund GP LLC&#8221;), Dr. Alexander J. Denner, Patrice Bonfiglio, Dr. Paul Cohen, Mark DiPaolo, Keith L. Horn, Odysseas Kostas, Louis
      Sterling III&#160; and Diane E. Sullivan.</div>
    <div>As of the date hereof and subject to the further explanatory information set forth in this paragraph, funds and other investment vehicles affiliated with Sarissa Capital and Dr. Denner may be deemed to beneficially own, within the meaning of Rule
      13d-3 under the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), 25,210,000 ordinary shares, par value 50 pence per share, of the Company (the &#8220;Shares&#8221;), as more fully described below. In addition, as of the date hereof, Mr. Sterling
      may be deemed to separately beneficially own, within the meaning of Rule 13d-3 under the Exchange Act, 117,772 Shares. Given Mr. Sterling&#8217;s beneficial ownership of Shares, he and the funds and other investment vehicles affiliated with Sarissa Capital
      and Dr. Denner may be deemed to have formed a group within the meaning of Rule 13d-5(b) under the Exchange Act. The number of Shares stated herein that may be deemed to be beneficially owned by Mr. Sterling does not include Shares that may be deemed
      to be beneficially owned by such funds and other investment vehicles, and the number of Shares stated herein that may be deemed to be beneficially owned by such funds and other investment vehicles does not include Shares that may be deemed to be
      beneficially owned by Mr. Sterling. Subject to the preceding sentence, as of the date hereof, the number of Shares that may be deemed to be beneficially owned, within the meaning of Rule 13d-3 under the Exchange Act, by funds and other investment
      vehicles affiliated with Sarissa Capital and Dr. Denner is as follows:</div>
    <div style="text-align: justify;"> <br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" align="center" id="z854cdf176d2040eebd1b7315dde99230" style="width: 60%; color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">

          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Sarissa Capital</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">25,210,000</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Offshore</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">6,188,100</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Master II</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">342,600</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Athena</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">3,164,000</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Catapult</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">4,298,200</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Hawkeye</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">3,928,800</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">ISP</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">6,663,377</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Atom</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">624,923</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Management GP</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">25,210,000</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Offshore GP</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">9,694,700</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Fund GP LP</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">17,921,700</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Fund GP LLC</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">17,921,700</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.09%; vertical-align: top;">
              <div style="text-align: justify;">Dr. Denner</div>
            </td>
            <td style="width: 49.91%; vertical-align: top;">
              <div style="text-align: right; font-family: 'Times New Roman',Times,serif;">25,210,000</div>
            </td>
          </tr>

      </table>
    </div>
    <br>
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    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><br>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.3
<SEQUENCE>4
<FILENAME>s58919650d.htm
<DESCRIPTION>EXHIBIT 6 - JOINT FILING AGREEMENT OF THE REPORTING PERSONS
<TEXT>
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    <div style="text-align: right;">EXHIBIT 6<br>
    </div>
    <div><br>
    </div>
    <div style="text-align: center;">JOINT FILING AGREEMENT</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">In accordance with Rule 13d&#8722;1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on Schedule 13D
      (including amendments thereto) with respect to the Ordinary Shares of Amarin Corporation plc and further agree that this Joint Filing Agreement be included as an Exhibit to such joint filings. The undersigned acknowledge that each shall be
      responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him or it contained herein or therein, but shall not be responsible for the completeness and accuracy of the information
      concerning the others, except to the extent that he or it knows or has reason to believe that such information is inaccurate. In evidence thereof, the undersigned, being duly authorized, have executed this Joint Filing Agreement.</div>
    <div><br>
    </div>
    <div>Dated: January 10, 2023</div>
    <div><br>
    </div>
    <div>SARISSA CAPITAL MANAGEMENT LP</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div>By:<font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font><u>/s/ Mark DiPaolo </u>_______________<br>
      <font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font>Name: Mark DiPaolo<br>
      <font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt" id="TRGRRTFtoHTMLTab">&#160;</font>Title: Senior Partner, General Counsel</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><u>/s/ Alexander J. Denner&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
      Alexander J. Denner</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><u>/s/ Louis Sterling III&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
      Louis Sterling III</div>
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<DOCUMENT>
<TYPE>EX-99.4
<SEQUENCE>5
<FILENAME>s58919650e.htm
<DESCRIPTION>EXHIBIT 7 - POWER OF ATTORNEY
<TEXT>
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    <div style="text-align: right;">EXHIBIT 7<br>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: center; margin-top: 12pt;">POWER OF ATTORNEY</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 24.5pt; margin-top: 12pt;">KNOW ALL MEN BY THESE PRESENTS THAT the undersigned hereby constitutes and appoints Mark DiPaolo and Patrice Bonfiglio and each of them severally, as the true and lawful
        attorneys and agents of the undersigned, with power to act with or without the others and with full power of substitution and resubstitution, to execute in the name, place and stead of the undersigned any statement or report, including any
        amendment to any statement or report, required to be filed with respect to the undersigned with respect to Amarin Corporation plc under Section&#160;13 or Section&#160;16 of the United States Securities Exchange Act of 1934, as amended, and any rules,
        regulations and requirements thereunder, including any forms or statements required to be submitted in connection with any electronic filing, or any statement or report, including any amendment to any statement or report, required to be filed with
        respect to the undersigned under any comparable laws, rules, regulations and requirements of any foreign jurisdiction, and to file any of the same with the Securities and Exchange Commission and any other appropriate U.S. and foreign regulatory
        authorities, said attorneys and agents having full power and authority to do and perform in the name and on behalf of the undersigned every act necessary to be done in the premises as fully and as effectually as the undersigned might or could do in
        person, and the undersigned hereby ratifies and confirms all that said attorneys and agents shall do or cause to be done by virtue hereof.</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="text-indent: 24.5pt; margin-top: 12pt;">IN WITNESS WHEREOF, the undersigned has subscribed these presents as of January 10, 2023.</div>
    </div>
    <div>
      <div style="font-size: 14pt;">&#160;</div>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z6958b43dcf144b52b8ac504dd254fc51">

        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top; border-bottom: 2px solid #000000;">
            <div>
              <div>/s/ Louis Sterling III <br>
              </div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">
            <div>Louis Sterling III</div>
          </td>
        </tr>

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    </div>
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