<SEC-DOCUMENT>0001140361-23-002125.txt : 20230119
<SEC-HEADER>0001140361-23-002125.hdr.sgml : 20230119
<ACCEPTANCE-DATETIME>20230119160029
ACCESSION NUMBER:		0001140361-23-002125
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230119
DATE AS OF CHANGE:		20230119

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMARIN CORP PLC\UK
		CENTRAL INDEX KEY:			0000897448
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-52399
		FILM NUMBER:		23537421

	BUSINESS ADDRESS:	
		STREET 1:		SPACES SOUTH DOCKLANDS, BLOCK C
		STREET 2:		77 SIR JOHN ROGERSON'S QUAY
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60
		BUSINESS PHONE:		353 1 6699 020

	MAIL ADDRESS:	
		STREET 1:		SPACES SOUTH DOCKLANDS, BLOCK C
		STREET 2:		77 SIR JOHN ROGERSON'S QUAY
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMARIN PHARMACEUTICALS PLC
		DATE OF NAME CHANGE:	20000201

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ETHICAL HOLDINGS PLC
		DATE OF NAME CHANGE:	19930322

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>ny20006859x3_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using Broadridge PROfile 22.12.1.5105
         Copyright 1995 - 2023 Broadridge -->
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
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    <div style="text-align: center;">
      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;" align="center"><font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">UNITED STATES</font><br>
      <font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font><br>
      <font style="font-size: 12pt;">Washington, D.C. 20549</font></div>
    <div>&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
    <div><br>
    </div>
    <div style="text-align: center;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center;">(Amendment No. 5)*<br>
      <br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="za2354448ad8f45a5a9ff7751ce0569bd" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 24pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Amarin Corporation plc</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Name of Issuer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">Ordinary Shares, par value 50 pence per share</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Title of Class of Securities)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">023111206</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(CUSIP Number)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">Mark DiPaolo</div>
            <div style="text-align: center;">Senior Partner, General Counsel</div>
            <div style="text-align: center;">Sarissa Capital Management LP</div>
            <div style="text-align: center;">660 Steamboat Road</div>
            <div style="text-align: center;">Greenwich, CT 06830</div>
            <div style="text-align: center;">203-302-2330</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Name, Address and Telephone Number of Person<br>
              Authorized to Receive Notices and Communications)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">January 18, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Date of Event which Requires Filing of this Statement)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g),
      check the following box. &#9744;</div>
    <div>&#160;</div>
    <div style="text-align: justify;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies
      are to be sent.</div>
    <div>&#160;</div>
    <div>*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures
      provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that
      section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
    <div>
      <div>
        <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
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    <div>
      <table id="z052f9e23dd1b43028af2cc2b0e1c2363" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 33.33%; text-align: left; vertical-align: bottom;">
              <div style="font-family: 'Times New Roman',Times,serif;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 33.33%;">
              <div>&#160;</div>
            </td>
            <td style="width: 33.33%; text-align: right; vertical-align: bottom;">
              <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 2 of 4 Pages</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 33.33%;">
              <div>&#160;</div>
            </td>
            <td style="width: 33.33%; text-align: center; vertical-align: bottom;">
              <div style="font-family: 'Times New Roman',Times,serif;">SCHEDULE 13D</div>
            </td>
            <td style="width: 33.33%;">
              <div>&#160;</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify;">This Amendment No. 5 to Schedule 13D (&#8220;Amendment No. 5&#8221;) relates to American Depositary Shares (&#8220;ADS(s)&#8221;), each ADS representing one ordinary share, par value 50 pence per share (the &#8220;Ordinary Shares&#8221;), issued by
      Amarin Corporation plc, a company incorporated under the laws of England and Wales (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on January 24, 2022 (the &#8220;Initial
      Schedule 13D&#8221;), as amended by Amendment No. 1 to Schedule 13D filed on June 3, 2022, Amendment No. 2 to Schedule 13D filed on June 16, 2022, Amendment No. 3 to Schedule 13D filed on October 11, 2022 and Amendment No. 4 to Schedule 13D filed on
      January 11, 2023 (the Initial Schedule 13D as so amended, the &#8220;Schedule 13D&#8221;). All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D.</div>
    <div>&#160;</div>
    <div style="text-align: justify;">This Amendment No. 5 is being filed to amend Item 4 and Item 7 as follows:</div>
    <div>&#160;</div>
    <div><font style="font-weight: bold;">Item 4.&#160; Purpose of Transaction. </font>Item 4 of the Schedule 13D is hereby amended to include the following:</div>
    <div>&#160;</div>
    <div style="text-align: justify;">On January 18, 2023, Sarissa Capital issued the press release attached as Exhibit 8 hereto.<br>
    </div>
    <div>&#160;</div>
    <div style="text-align: justify;"><font style="font-weight: bold;">Item 7.&#160; Material to Be Filed as Exhibits. </font>Item 7 of the Schedule 13D is hereby amended to include the following:</div>
    <div>&#160;</div>
    <div>Exhibit 8 &#8211; Press Release, January 18, 2023</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    <table id="029f328a0372483c98b18b1d6117f058" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 33.33%; text-align: left; vertical-align: bottom;">
            <div>CUSIP No. 023111206</div>
          </td>
          <td style="width: 33.33%;">&#160;</td>
          <td style="width: 33.33%; text-align: right; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 3 of 4 Pages</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33.33%;">&#160;</td>
          <td style="width: 33.33%; text-align: center; vertical-align: bottom;">SCHEDULE 13D</td>
          <td style="width: 33.33%;">&#160;</td>
        </tr>

    </table>
    <div>&#160;</div>
    <div style="text-align: center; font-weight: bold;">SIGNATURE</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div>Dated: January 18, 2023</div>
    <div><br>
    </div>
    <div>
      <table id="z7b3d306720824f14ac0c546eeac97483" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td colspan="2" rowspan="1" style="width: 5%;">SARISSA CAPITAL MANAGEMENT LP</td>
            <td style="width: 50%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%;">
              <div>&#160;</div>
            </td>
            <td style="width: 45%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%; padding-bottom: 2px;">By:</td>
            <td style="width: 45%; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Mark DiPaolo<br>
            </td>
            <td style="width: 50%; padding-bottom: 2px;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%;">
              <div>&#160;</div>
            </td>
            <td style="width: 45%;">Name: Mark DiPaolo<br>
            </td>
            <td style="width: 50%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5%;">
              <div>&#160;</div>
            </td>
            <td style="width: 45%;">Title: Senior Partner, General Counsel</td>
            <td style="width: 50%;">
              <div>&#160;</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table id="z2a3e6925600f4752bc896c71ee8bda85" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 50%; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Alexander J. Denner</td>
            <td style="width: 50%; padding-bottom: 2px;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">Alexander J. Denner</td>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Louis Sterling III</td>
            <td style="width: 50%; padding-bottom: 2px;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">Louis Sterling III</td>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
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    <table id="2864eff1ef69407e8410cb14c6d8e618" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 33.33%; text-align: left; vertical-align: bottom;">
            <div>CUSIP No. 023111206</div>
          </td>
          <td style="width: 33.33%;">&#160;</td>
          <td style="width: 33.33%; text-align: right; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 4 of 4 Pages</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33.33%;">&#160;</td>
          <td style="width: 33.33%; text-align: center; vertical-align: bottom;">SCHEDULE 13D</td>
          <td style="width: 33.33%;">&#160;</td>
        </tr>

    </table>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">INDEX TO EXHIBITS</div>
    <div><br>
    </div>
    <div>Exhibit 1 &#8211; Joint Filing Agreement of the Reporting Persons*</div>
    <div>&#160;</div>
    <div>Exhibit 2 &#8211; Press Release, June 15, 2022*</div>
    <div>&#160;</div>
    <div>Exhibit 3 &#8211; Press Release, October 11, 2022*</div>
    <div>&#160;</div>
    <div>Exhibit 4 &#8211; Requisition Notice, January 10, 2023*</div>
    <div>&#160;</div>
    <div>Exhibit 5 &#8211; Press Release, January 10, 2023*</div>
    <div>&#160;</div>
    <div>Exhibit 6 &#8211; Joint Filing Agreement of the Reporting Persons*</div>
    <div>&#160;</div>
    <div>Exhibit 7 &#8211; Power of Attorney Granted by Louis Sterling III in favor of Mark DiPaolo and Patrice Bonfiglio, January 10, 2023*</div>
    <div>&#160;</div>
    <div><a href="ny20006859x3_ex-8.htm">Exhibit 8</a> &#8211; Press Release, January 18, 2023</div>
    <div>&#160;</div>
    <div><br>
    </div>
    <div>*&#160; Previously filed.</div>
    <div style="text-align: right;"><br>
    </div>
    <div>
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.8
<SEQUENCE>2
<FILENAME>ny20006859x3_ex-8.htm
<DESCRIPTION>EXHIBIT 99.8
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using Broadridge PROfile 22.12.1.5105
         Copyright 1995 - 2023 Broadridge -->
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <font style="font-family: 'Times New Roman',Times,serif;"></font>
  <div>
    <div style="text-align: right;">
      <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"><font style="font-weight: bold;">EXHIBIT 8</font><br>
    </div>
    <div style="text-align: right;"> <br>
    </div>
    <div>
      <div style="text-align: center; font-size: 14pt;">Sarissa Capital Calls Out Amarin&#8217;s Sham Board Refreshment</div>
      <div style="text-align: center;"> <br>
      </div>
      <div style="text-align: center;">Sarissa puts little faith in Chairman Per Wold-Olsen&#8217;s board refreshment process that resulted in NO SHAREHOLDER </div>
      <div style="text-align: center;">REPRESENTATIVES ON THE BOARD</div>
      <div style="text-align: center;"> <br>
      </div>
      <div style="text-align: center;">Sarissa believes the board&#8217;s refusal to consider shareholder input on the board despite Amarin&#8217;s failures indicates the current board </div>
      <div style="text-align: center;">does not prioritize interests of shareholders</div>
      <div><br>
      </div>
      <div style="text-align: justify;">Greenwich, CT, January 18, 2023 &#8211; Sarissa Capital Management LP (&#8220;Sarissa&#8221;) today made the following statement on Amarin Corporation plc (NASDAQ: AMRN):</div>
      <div style="text-align: justify;"> <br>
      </div>
      <div>In 2022 alone, Amarin stock lost over two-thirds of its value, and shareholders lost over $840 million in equity.* The European launch is behind schedule, reimbursement in Germany (typically one of the largest markets in Europe) appears
        imperiled, and spending mismanagement has weakened the cash coffers. Yet the board has the audacity to state publicly, &#8220;the Company made solid progress in 2022, against its strategic objectives.&#8221; To shareholders, the owners of the company, these
        statements are gravely concerning because they reflect a total lack of understanding of events and the mission of the board and management &#8211; to maximize value for shareholders. To do so, the company must not destroy value.</div>
      <div> <br>
      </div>
      <div>Indeed, Amarin has repeatedly overpromised and underdelivered. Below are three of many examples.</div>
      <div> <br>
      </div>
      <div>
        <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="zdda2698dfab64d439b2c0bbf42c953b2" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 18pt; vertical-align: top; text-align: right;">
                <div style="text-align: left;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div>Vascepa is a great drug with the potential to have a meaningful impact on society. However, since the label expansion for cardiovascular risk reduction, Amarin stock has lost over 90% of its value.<sup style="font-family: Roboto; vertical-align: text-top; line-height: 1; font-size: smaller;">&#8224;</sup></div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div>
        <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z636c3a6c5f394756a6a5df82e47d605c" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 18pt; vertical-align: top; text-align: right;">
                <div style="text-align: left;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div>Last year, management committed to launching in up to six key European markets and obtain pricing and reimbursement approval in up to eight European markets in 2022. They launched and&#160;secured positive pricing and reimbursement
                  decisions in only five European markets. In addition, despite the novel drug&#8217;s ability to reduce cardiovascular events and its significant potential to reduce a country&#8217;s healthcare costs, Amarin could not secure reimbursement approval in
                  Germany, a historically top revenue generating country for pharmaceuticals in Europe.</div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div>
        <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" class="DSPFListTable" id="z29b8302be3a94cd29292536f72af6b37" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 18pt; vertical-align: top; text-align: right;">
                <div style="text-align: left;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div>Amarin&#8217;s slow, reactive responses to changing market dynamics have destroyed significant shareholder capital. An alarming example from 2022 is Amarin&#8217;s slow response to the US launch of a third generic in January 2022 that quickly and
                  meaningfully reduced sales via both price and volume. Instead of having a plan ready to enact immediately in response to the long anticipated generic risk, Amarin waited six months, until June 2022, to announce a major reduction in
                  expenses. In that time, significant shareholder capital &#8211; and additional credibility of management and the board &#8211; were destroyed.</div>
              </td>
            </tr>

        </table>
      </div>
      <div> <br>
      </div>
      <div>In June 2022, shareholders loudly expressed their lack of faith in the board and management at the shareholder meeting. Shareholders such as ourselves share the concern, among many concerns, that the current management and board will continue to
        overpromise and underdeliver and destroy shareholder capital, mismanage expenses, run out of money and massively dilute existing shareholders.</div>
      <div> <br>
      </div>
      <div>Characterizing the board&#8217;s interaction with Sarissa as &#8220;in good faith&#8221; is a gross misrepresentation of the facts. The board, led by Chairman Per Wold-Olsen, showed no sense of urgency in interviewing shareholder candidates for the board and took
        fifteen weeks to interview three Sarissa candidates. A few of the directors acknowledged following Chairman Per Wold-Olsen&#8217;s lead and that the time to interview directors was unnecessarily lengthy. His insistence on a lengthy process confused the
        duration with quality of process, and ultimately the board rejected adding any shareholder representatives to the board in favor of their own candidates. Shareholders are the owners of the company with a vested interest in the company&#8217;s success.
        Yet the board is devoid of any shareholder representatives.</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div class="BRPFPageBreak" style="page-break-after: always;">
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      </div>
      <div>Sarissa is Amarin&#8217;s largest shareholder and has a history of creating significant shareholder value in healthcare companies, including those with cardiovascular drugs such as The Medicines Company. We can only conclude that Amarin&#8217;s board does
        not seek real change and instead wants to remain entrenched at the expense of shareholders.</div>
      <div> <br>
      </div>
      <div>As detailed in our previous press release<sup style="font-family: Roboto; vertical-align: text-top; line-height: 1; font-size: smaller;">&#8224;&#8224;</sup>, Sarissa has submitted notice to Amarin to call a special meeting to remove Chairman Per Wold-Olsen
        from the board and add 7 directors to the board. In accordance with UK law, Amarin has up to 21 days to call the special meeting, which must be held within 28 days of calling the special meeting. We are asking all shareholders to remain engaged and
        voice their opinions by voting at the special meeting.</div>
      <div><br>
      </div>
      <div>Many shareholders have reached out asking us how to vote at the special meeting, and we will provide instructions in the coming weeks and ahead of the meeting.</div>
      <div><br>
      </div>
      <div>*Calculated between Dec 31, 2021, and Dec 30, 2022, Bloomberg</div>
      <div><sup style="font-family: Roboto; vertical-align: text-top; line-height: 1; font-size: smaller;">&#8224;</sup>Calculated between Dec 13, 2019, and Jan 13, 2023, Bloomberg</div>
      <div><sup style="font-family: Roboto; vertical-align: text-top; line-height: 1; font-size: smaller;">&#8224;&#8224;</sup>Press release link: <u>https://www.businesswire.com/news/home/20230109005938/en/Sarissa-Capital-Submits-Notice-to-Call-a-Special-Meeting-of-Amarin-Shareholders-to-Add-Directors-and-Remove-Chairman-Per-Wold-Olsen</u></div>
      <br>
      <div style="text-align: center; text-indent: -72pt; margin-left: 72pt;">###</div>
      <div style="text-align: center; text-indent: -72pt; margin-left: 72pt;"> <br>
      </div>
      <div style="text-align: center; font-style: italic;">CERTAIN INFORMATION CONCERNING THE PARTICIPANTS</div>
      <div style="text-align: center; font-style: italic;"> <br>
      </div>
      <div style="text-align: justify;">Sarissa Capital Management LP (&#8220;Sarissa Capital&#8221;), together with the other participants named herein (collectively, &#8220;Sarissa&#8221;), intends to file a preliminary proxy statement and accompanying proxy card with the
        Securities and Exchange Commission (&#8220;SEC&#8221;) to be used to solicit votes for the election of its slate of highly-qualified nominees as directors of Amarin Corporation plc (NASDAQ: AMRN) (the &#8220;Company&#8221;), at a special meeting of shareholders of the
        Company. SARISSA STRONGLY ADVISES ALL SHAREHOLDERS OF THE COMPANY TO READ THE PROXY STATEMENT AND OTHER PROXY MATERIALS AS THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION. SUCH PROXY MATERIALS WILL BE AVAILABLE AT NO CHARGE ON
        THE SEC&#8217;S WEB SITE AT HTTP://WWW.SEC.GOV. IN ADDITION, THE PARTICIPANTS IN THIS PROXY SOLICITATION WILL PROVIDE COPIES OF THE PROXY STATEMENT WITHOUT CHARGE, WHEN AVAILABLE, UPON REQUEST. REQUESTS FOR COPIES SHOULD BE DIRECTED TO THE PARTICIPANTS&#8217;
        PROXY SOLICITOR, THE IDENTITY AND CONTACT INFORMATION FOR WHICH WILL BE SET FORTH IN THE PROXY STATEMENT THAT WILL BE MADE AVAILABLE TO SHAREHOLDERS.</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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      </div>
      <div style="text-align: justify;">The participants in the proxy solicitation are anticipated to include Sarissa Capital, Sarissa Capital Offshore Master Fund LP (&#8220;Offshore&#8221;), Sarissa Capital Master Fund II LP (&#8220;Master II&#8221;), Sarissa Capital Athena
        Offshore Fund Ltd (&#8220;Athena&#8221;), Sarissa Capital Catapult Fund LLC (&#8220;Catapult&#8221;), Sarissa Capital Hawkeye Fund LP (&#8220;Hawkeye&#8221;), ISP Fund LP (&#8220;ISP&#8221;), Atom Master Fund LP (&#8220;Atom&#8221;), Sarissa Capital Management GP LLC (&#8220;Management GP&#8221;), Sarissa Capital
        Offshore Fund GP LLC (&#8220;Offshore GP&#8221;), Sarissa Capital Fund GP LP (&#8220;Fund GP LP&#8221;), Sarissa Capital Fund GP LLC (&#8220;Fund GP LLC&#8221;), Dr. Alexander J. Denner, Patrice Bonfiglio, Dr. Paul Cohen, Mark DiPaolo, Keith L. Horn, Odysseas Kostas, Louis Sterling
        III&#160; and Diane E. Sullivan.</div>
      <div style="text-align: justify;"> <br>
      </div>
      <div style="text-align: justify;">As of the date hereof and subject to the further explanatory information set forth in this paragraph, funds and other investment vehicles affiliated with Sarissa Capital and Dr. Denner may be deemed to beneficially
        own, within the meaning of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), 25,210,000 ordinary shares, par value 50 pence per share, of the Company (the &#8220;Shares&#8221;), as more fully described below. In addition,
        as of the date hereof, Mr. Sterling may be deemed to separately beneficially own, within the meaning of Rule 13d-3 under the Exchange Act, 117,772 Shares. Given Mr. Sterling&#8217;s beneficial ownership of Shares, he and the funds and other investment
        vehicles affiliated with Sarissa Capital and Dr. Denner may be deemed to have formed a group within the meaning of Rule 13d-5(b) under the Exchange Act. The number of Shares stated herein that may be deemed to be beneficially owned by Mr. Sterling
        does not include Shares that may be deemed to be beneficially owned by such funds and other investment vehicles, and the number of Shares stated herein that may be deemed to be beneficially owned by such funds and other investment vehicles does not
        include Shares that may be deemed to be beneficially owned by Mr. Sterling. Subject to the preceding sentence, as of the date hereof, the number of Shares that may be deemed to be beneficially owned, within the meaning of Rule 13d-3 under the
        Exchange Act, by funds and other investment vehicles affiliated with Sarissa Capital and Dr. Denner is as follows:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z3fc80c5b2aa7451aa7fcaf5ed92c8d90" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Sarissa Capital</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">25,210,000</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Offshore</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">6,188,100</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Master II</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">342,600</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Athena</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">3,164,000</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Catapult</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">4,298,200</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Hawkeye</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">3,928,800</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">ISP</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">6,663,377</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Atom</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">624,923</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Management GP</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">25,210,000</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Offshore GP</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">9,694,700</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Fund GP LP</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">17,921,700</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Fund GP LLC</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">17,921,700</div>
            </td>
          </tr>
          <tr>
            <td colspan="1" style="width: 36pt; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">
              <div style="text-align: justify;">Dr. Denner</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">25,210,000</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div>
        <div></div>
        <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;">Contact:</td>
              <td style="width: auto; vertical-align: top;">
                <div>Jean Puong<br>
                  Sarissa Capital Management LP<br>
                  info@sarissacap.com</div>
              </td>
            </tr>

        </table>
        <div style="text-align: center; text-indent: -72pt; margin-left: 72pt;">&#160;</div>
      </div>
      <div>
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