<SEC-DOCUMENT>0001140361-23-007234.txt : 20230215
<SEC-HEADER>0001140361-23-007234.hdr.sgml : 20230215
<ACCEPTANCE-DATETIME>20230215160051
ACCESSION NUMBER:		0001140361-23-007234
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230215
DATE AS OF CHANGE:		20230215
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.
GROUP MEMBERS:		LOUIS STERLING III

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMARIN CORP PLC\UK
		CENTRAL INDEX KEY:			0000897448
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-52399
		FILM NUMBER:		23635312

	BUSINESS ADDRESS:	
		STREET 1:		SPACES SOUTH DOCKLANDS, BLOCK C
		STREET 2:		77 SIR JOHN ROGERSON'S QUAY
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60
		BUSINESS PHONE:		353 1 6699 020

	MAIL ADDRESS:	
		STREET 1:		SPACES SOUTH DOCKLANDS, BLOCK C
		STREET 2:		77 SIR JOHN ROGERSON'S QUAY
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMARIN PHARMACEUTICALS PLC
		DATE OF NAME CHANGE:	20000201

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ETHICAL HOLDINGS PLC
		DATE OF NAME CHANGE:	19930322

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>ny20006859x21_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
<html>
  <head>
    <title></title>
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         Document created using Broadridge PROfile 23.1.2.5118
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<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
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    <div style="text-align: center;">
      <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;" align="center"><font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">UNITED STATES</font><font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif;"><br>
      </font><font style="font-size: 14pt; font-family: 'Times New Roman',Times,serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</font><br>
      <font style="font-size: 12pt;">Washington, D.C. 20549</font></div>
    <div>&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
    <div><br>
    </div>
    <div style="text-align: center;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center;">(Amendment No. 9)*<br>
      <br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zfda57d7eecb14c438ee5efa11eebc875" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 24pt;">
            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Amarin Corporation plc</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Name of Issuer)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">Ordinary Shares, par value 50 pence per share</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Title of Class of Securities)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">023111206</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(CUSIP Number)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">Mark DiPaolo</div>
            <div style="text-align: center;">Senior Partner, General Counsel</div>
            <div style="text-align: center;">Sarissa Capital Management LP</div>
            <div style="text-align: center;">660 Steamboat Road</div>
            <div style="text-align: center;">Greenwich, CT 06830</div>
            <div style="text-align: center;">203-302-2330</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Name, Address and Telephone Number of Person<br>
              Authorized to Receive Notices and Communications)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;">February 14, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center;">(Date of Event which Requires Filing of this Statement)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g),
      check the following box. </div>
    <div>&#160;</div>
    <div style="text-align: justify;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies
      are to be sent.</div>
    <div>&#160;</div>
    <div>*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures
      provided in a prior cover page.</div>
    <div><br>
    </div>
    <div>The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be
      subject to all other provisions of the Act (however, see the Notes).<br>
      <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
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    <div>
      <table id="zdb26263e585b4227a2fc2dbd2a3131cd" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 50.00%;">
              <div style="text-align: left;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 50.00%;">
              <div style="text-align: right;">
                <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 2 of&#160; 7 Pages</font></div>
              </div>
            </td>
          </tr>
          <tr>
            <td colspan="2" rowspan="1" style="width: 50.00%;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div> <br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zbe80f8f0fd0f42daa833deaae629df25" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>1</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Sarissa Capital Management LP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>2</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>(a) &#160; &#160;&#160;&#160; &#9744; </div>
            <div>(b)&#160;&#160; &#160;&#160;&#160; &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>3</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>4</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOURCE OF FUNDS<br>
              <br>
              WC</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>5</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="border-bottom: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: top; width: 16%;">&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>6</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              Delaware</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" rowspan="4" style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>7</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOLE VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>8</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SHARED VOTING POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>9</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>10</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>11</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>12</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>13</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              6.22%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>14</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>PN</div>
          </td>
        </tr>

    </table>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    <div>
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        <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 50.00%;">
                <div style="text-align: left;">CUSIP No. 023111206</div>
              </td>
              <td style="width: 50.00%;">
                <div style="text-align: right;">
                  <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 3 of 7 Pages</font></div>
                </div>
              </td>
            </tr>
            <tr>
              <td colspan="2" rowspan="1" style="width: 50.00%;">
                <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">SCHEDULE 13D</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
      </div>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zb052baebe3c3498daa73a2e863ab5d45" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>1</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Alexander J. Denner, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>2</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div><br>
              (a)&#160;&#160;&#160;&#160;&#160;&#160; &#9744;&#160; <br>
            </div>
            <div>(b)&#160;&#160; &#160;&#160;&#160; &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>3</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>4</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOURCE OF FUNDS<br>
              <br>
              AF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>5</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>6</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              United States</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" rowspan="4" style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>7</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOLE VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>8</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SHARED VOTING POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>9</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>10</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>11</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              25,210,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>12</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>13</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              6.22%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>14</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>IN</div>
          </td>
        </tr>

    </table>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 50.00%;">
              <div style="text-align: left;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 50.00%;">
              <div style="text-align: right;">
                <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 4 of 7 Pages</font></div>
              </div>
            </td>
          </tr>
          <tr>
            <td colspan="2" rowspan="1" style="width: 50.00%;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zf2b960553dc74faeac6b1f1431904a96" border="0" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>1</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>NAME OF REPORTING PERSON OR<br>
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
              <br>
              Louis Sterling III</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>2</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div><br>
              (a)&#160;&#160;&#160;&#160;&#160;&#160; &#9744;</div>
            <div>(b)&#160;&#160;&#160;&#160;&#160;&#160; &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>3</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>4</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOURCE OF FUNDS<br>
              <br>
              PF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>5</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>6</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION<br>
              <br>
              United States</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" rowspan="4" style="vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>7</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOLE VOTING POWER<br>
              <br>
              69,772</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>8</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SHARED VOTING POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>9</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SOLE DISPOSITIVE POWER<br>
              <br>
              69,772</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>10</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>SHARED DISPOSITIVE POWER<br>
              <br>
              0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>11</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>
              <br>
              69,772</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>12</div>
          </td>
          <td colspan="3" style="vertical-align: top; border-left: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES:</div>
          </td>
          <td style="width: 16%; vertical-align: top; border-right: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">&#9744;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>13</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>
              <br>
              Less than 1%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>14</div>
          </td>
          <td colspan="4" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>TYPE OF REPORTING PERSON<br>
              &#160;</div>
            <div>IN</div>
          </td>
        </tr>

    </table>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 50.00%;">
              <div style="text-align: left;">CUSIP No. 023111206</div>
            </td>
            <td style="width: 50.00%;">
              <div style="text-align: right;">
                <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 5 of 7 Pages</font></div>
              </div>
            </td>
          </tr>
          <tr>
            <td colspan="2" rowspan="1" style="width: 50.00%;">
              <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">SCHEDULE 13D</div>
            </td>
          </tr>

      </table>
    </div>
    <div>&#160;</div>
    <div style="text-align: justify;">This Amendment No. 9 to Schedule 13D (&#8220;Amendment No. 9&#8221;) relates to American Depositary Shares (&#8220;ADS(s)&#8221;), each ADS representing one ordinary share, par value 50 pence per share (the &#8220;Ordinary Shares&#8221;), issued by
      Amarin Corporation plc, a company incorporated under the laws of England and Wales (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on January 24, 2022 (the &#8220;Initial
      Schedule 13D&#8221;), as amended by Amendment No. 1 to Schedule 13D filed on June 3, 2022, Amendment No. 2 to Schedule 13D filed on June 16, 2022, Amendment No. 3 to Schedule 13D filed on October 11, 2022, Amendment No. 4 to Schedule 13D filed on January
      11, 2023, Amendment No. 5 to Schedule 13D filed on January 19, 2023, Amendment No. 6 to Schedule 13D filed on February 8, 2023, Amendment No. 7 to Schedule 13D filed on February 10, 2023, and Amendment No. 8 to Schedule 13D filed on February 14, 2023
      (the Initial Schedule 13D as so amended, the &#8220;Schedule 13D&#8221;). All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D.</div>
    <div>&#160;</div>
    <div style="text-align: justify;">This Amendment No. 9 is being filed to amend Item 4, Item 5(a) and Item 7 as follows:</div>
    <div>&#160;</div>
    <div><font style="font-weight: bold;">Item 4.&#160; Purpose of Transaction. </font>Item 4 of the Schedule 13D is hereby amended to include the following:</div>
    <div>&#160;</div>
    <div>On February 14, 2023, Sarissa Capital issued the press release attached as Exhibit 12 hereto.</div>
    <div>&#160;</div>
    <div> <font style="font-weight: bold;">Item 5. Interest in Securities of the Issuer.</font> Item 5(a) of the Schedule 13D is hereby amended and restated as follows:<br>
    </div>
    <div> <br>
    </div>
    <div>
      <table id="za386317dbbba49b996943ed6293a2411" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td colspan="1" style="width: 3%;">&#160;</td>
            <td style="width: 3%; text-align: left; vertical-align: top;">(a)</td>
            <td style="width: 94%;">The Sarissa Reporting Persons may be deemed to beneficially own, in the aggregate, 25,210,000 Shares representing approximately 6.22% of the outstanding Shares (the &#8220;Sarissa Shares&#8221;). Mr. Sterling may be deemed to
              beneficially own, in the aggregate, 69,772 Shares representing approximately 0.02% of the outstanding Shares (the &#8220;Sterling Shares&#8221;), including call options representing 5,500 Shares (as further described in Item 6). Percentages of the
              outstanding Shares are based upon the 405,209,963 Shares outstanding as of January 23, 2023, including 384,708,057 ADSs, and 20,501,906 Ordinary Shares, as set forth in Schedule 14A of the Issuer filed with the SEC on January 31, 2023.</td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify;"><font style="font-weight: bold;">Item 7.&#160; Material to Be Filed as Exhibits. </font>Item 7 of the Schedule 13D is hereby amended to include the following:</div>
    <div>&#160;</div>
    <div>Exhibit 12 &#8211; Press Release, February 14, 2023</div>
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      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div style="text-align: center; font-weight: bold;">
      <div>
        <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 50.00%;">
                <div style="text-align: left;">CUSIP No. 023111206</div>
              </td>
              <td style="width: 50.00%;">
                <div style="text-align: right;">
                  <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 6 of 7 Pages</font></div>
                </div>
              </td>
            </tr>
            <tr>
              <td colspan="2" rowspan="1" style="width: 50.00%;">
                <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">SCHEDULE 13D</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">SIGNATURE</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div>Dated: February 15, 2023</div>
    <div> <br>
    </div>
    <div>
      <div>SARISSA CAPITAL MANAGEMENT LP</div>
    </div>
    <div><br>
    </div>
    <div>
      <table id="z319ad3ce081541b39a500a2a5ce9d9e7" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 3%; padding-bottom: 2px;">By: <br>
            </td>
            <td colspan="2" rowspan="1" style="border-bottom: 2px solid rgb(0, 0, 0);">&#160;/s/ Mark DiPaolo<br>
            </td>
            <td colspan="1" style="width: 62%; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 3%;">
              <div>&#160;</div>
            </td>
            <td style="width: 5%;">Name: <br>
            </td>
            <td colspan="1" style="width: 30%;">Mark DiPaolo</td>
            <td colspan="1" style="width: 62%;">&#160;</td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 3%;">&#160;</td>
            <td rowspan="1" style="width: 5%;">Title: <br>
            </td>
            <td rowspan="1" colspan="1" style="width: 30%;">Senior Partner, General Counsel</td>
            <td rowspan="1" colspan="1" style="width: 62%;">&#160;</td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 3%;">&#160;</td>
            <td rowspan="1" style="width: 5%;">&#160;</td>
            <td rowspan="1" colspan="1" style="width: 30%;">&#160;</td>
            <td rowspan="1" colspan="1" style="width: 62%;">&#160;</td>
          </tr>
          <tr>
            <td colspan="3" rowspan="1" style="width: 3%; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Alexander J. Denner<br>
            </td>
            <td rowspan="1" colspan="1" style="width: 62%; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td colspan="3" rowspan="1" style="width: 3%;">Alexander J. Denner</td>
            <td rowspan="1" colspan="1" style="width: 62%;">&#160;</td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 3%;">&#160;</td>
            <td rowspan="1" style="width: 5%;">&#160;</td>
            <td rowspan="1" colspan="1" style="width: 30%;">&#160;</td>
            <td rowspan="1" colspan="1" style="width: 62%;">&#160;</td>
          </tr>
          <tr>
            <td colspan="3" rowspan="1" style="width: 3%; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Louis Sterling III&#160;&#160;</td>
            <td rowspan="1" colspan="1" style="width: 62%; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td colspan="3" rowspan="1" style="width: 3%;">Louis Sterling III&#160;&#160;</td>
            <td rowspan="1" colspan="1" style="width: 62%;">&#160;</td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 3%;">&#160;</td>
            <td rowspan="1" style="width: 5%;">&#160;</td>
            <td rowspan="1" colspan="1" style="width: 30%;">&#160;</td>
            <td rowspan="1" colspan="1" style="width: 62%;">&#160;</td>
          </tr>

      </table>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div>
      <div>
        <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 50.00%;">
                <div style="text-align: left;">CUSIP No. 023111206</div>
              </td>
              <td style="width: 50.00%;">
                <div style="text-align: right;">
                  <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-size: 10pt;">Page 7 of 7 Pages</font></div>
                </div>
              </td>
            </tr>
            <tr>
              <td colspan="2" rowspan="1" style="width: 50.00%;">
                <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">SCHEDULE 13D</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">INDEX TO EXHIBITS</div>
    <div><a href="ny20006859x21_ex12.htm"><br>
      </a> </div>
    <a href="ny20006859x21_ex12.htm"> </a>
    <div><a href="ny20006859x21_ex12.htm">Exhibit 12</a> &#8211; Press Release, February 14, 2023</div>
    <div>&#160;
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
    <br>
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<TYPE>EX-12
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<FILENAME>ny20006859x21_ex12.htm
<DESCRIPTION>EXHIBIT 12
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    <div style="text-align: center; font-weight: bold;">SARISSA CAPITAL DISAPPOINTED THAT AMARIN WEBCAST CONTINUES BOARD&#8217;S DEFENSE OF POOR RESULTS AND LACK OF ACCOUNTABILITY</div>
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    <div style="text-align: center; font-weight: bold;">Sarissa Believes Amarin Board Missed an Opportunity for its <u>First</u> True Engagement with Frustrated Shareholder Base</div>
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    <div style="text-align: center; font-weight: bold;">Sarissa Points to Several Statements Made by the Amarin Board Which Demonstrate a Complete Lack of Understanding of the Reality for Amarin Shareholders</div>
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    <div style="text-align: justify;">Greenwich, CT, February 14, 2023 &#8211; Sarissa Capital Management LP (&#8220;Sarissa&#8221;) today issued the following statement regarding Amarin Corporation plc (NASDAQ: AMRN):</div>
    <div>Sarissa Capital believes that today&#8217;s Amarin webcast was yet again tone-deaf to shareholders and another display by management of a lack of accountability for its poor performance. Today&#8217;s webcast was a missed opportunity for Amarin leadership to
      truly engage with frustrated shareholders, take accountability for their numerous missteps and embrace the benefits of shareholder representation and oversight. Instead, the board astonishingly contends that they are doing a great job and should
      change nothing going forward.</div>
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    <div>The board made many head scratching statements that fortify our belief that necessary change will not occur under current leadership.</div>
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              <div style="text-align: left; margin-left: 18pt;">&#8226;</div>
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              <div>CEO Karim Mikhail stated today: &#8220;&#8230;we have delivered this year on every objective we had in a consistent way.&#8221; <font style="font-weight: bold;">Meanwhile, shareholders have suffered greatly. In 2022 alone, shareholders lost &gt;$840M in
                  value due to repeated missteps by management.*</font></div>
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              <div>CEO Karim Mikhail also stated that shareholder engagement has been a top priority for the company since day 1 of his tenure. <font style="font-weight: bold;">This is the first time in his two-year tenure that the company hosted a
                  webcast aimed at its retail shareholder base.</font></div>
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              <div>Board Member Erin Enright indicated they were &#8220;quite quick&#8221; on cost cutting, including in the face of an expected 3<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">rd</sup> generic in January 2022. <font style="font-weight: bold;">Even after it took Amarin 6 months to announce a cost reduction plan. This is NOT &#8220;quite quick.&#8221; Watching weekly prescription volume does not equal preparedness for a plan to act.</font></div>
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              <div style="text-align: left; margin-left: 18pt; font-weight: bold;">&#8226;</div>
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              <div>Board Member Erin Enright also indicated<font style="font-weight: bold;">&#160;</font>Amarin&#8217;s high compensation levels in the face of the company&#8217;s poor results are warranted. <font style="font-weight: bold;">Unfortunately for Amarin
                  shareholders sometimes you DON&#8217;T get what you pay for:</font></div>
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              <div style="text-align: left; margin-left: 54pt; font-weight: bold;">o</div>
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              <div>CEO Karim Mikhail was paid &gt;$5.8M in total compensation in 2021 when the stock declined &gt;31% and shareholders lost &gt;$560M in value.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"> &#8224;</sup></div>
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              <div>Chairman Per Wold-Olsen was granted approximately $1M in compensation in 2022 when the stock lost &gt;64% of its value that year.<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"> &#8224;</sup></div>
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              <div>Board Member Adam Berger applauded the company&#8217;s boots on the ground efforts in China. <font style="font-weight: bold;">Yet, years after Amarin submitted Vascepa, it is still not approved in China despite years of missing its guidance</font>.</div>
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              <div>Amarin was unable to secure German reimbursement and continues to blame external factors without taking any accountability. Novartis, a global biopharmaceutical company with vast experience commercialization in Europe had a different
                view of Germany, recently stating <font style="font-weight: bold;">&#8220;&#8230;Germany has had some headwinds. But overall, the German environment, we&#8217;d say, is relatively positive and workable&#8230; I think Germany remains [a] most attractive market.&#8221;</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#160;</sup><sup style="font-weight: bold; vertical-align: text-top; line-height: 1; font-size: smaller;">&#8225;</sup></div>
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              <div>Board Member Erin Enright claimed that spending &gt;$7M for this campaign was necessary given the &#8220;diffuse shareholder base.&#8221; <font style="font-weight: bold;">Conversely, Sarissa has spent approximately $1M and has effectively
                  communicated with shareholders, who have shared their frustration with us on the lack of progress and accountability at Amarin. Either Amarin does not know how to spend money efficiently or does not care about shareholders&#8217; money.</font></div>
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    <div>Amarin is in dire need of change. It is clear to us that current Amarin leadership will not fix the problems at Amarin because they do not believe that any problems exist. This harsh reality for shareholders was made painfully apparent on today&#8217;s
      webcast where board members eschewed any accountability for the company&#8217;s current situation and urged shareholders to stay the course &#8211; a course that to date has resulted in tremendous destruction of shareholder value. Sarissa is Amarin&#8217;s largest
      shareholder. We are long term shareholders and have not sold any shares since acquiring our position. We have a stellar track record of success, including in the cardiovascular space. Our nominees have the experience and qualifications to help unlock
      Amarin&#8217;s true potential.</div>
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    <div>We urge all shareholders to vote the <font style="font-weight: bold; color: #002060;">BLUE</font><font style="color: #002060;">&#160;</font>proxy card &#8220;<font style="font-weight: bold;">FOR</font>&#8221; the Sarissa Nominees and &#8220;<font style="font-weight: bold;">FOR</font>&#8221; the removal of Chairman Per Wold-Olsen on or prior to the deadline on Tuesday, February 21, 2023.</div>
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    <div>If you have not received a <font style="font-weight: bold; color: #002060;">BLUE</font><font style="color: #002060;">&#160;</font>proxy card, you can vote the white proxy card but you must vote &#8220;<font style="font-weight: bold;">FOR</font>&#8221; all
      proposals on the white proxy card to have the same effect as a vote &#8220;<font style="font-weight: bold;">FOR</font>&#8221; all proposals on the <font style="font-weight: bold; color: #002060;">BLUE</font> proxy card.&#160; If holders want to fully support
      Sarissa, they must make sure that all &#8220;<font style="font-weight: bold;">FOR</font>&#8221; boxes are marked on your proxy card before you submit it.&#160; <font style="font-weight: bold;">If you have any questions on how to vote, we recommend that you contact
        Sarissa&#8217;s proxy solicitor, D.F. King, by calling (800) 331-7024 or emailing AMRN@dfking.com</font></div>
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    <div>#FreeAmarin</div>
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    <div>Visit our website at www.freeamarin.com<font style="color: #0563C1;"><u>&#160;</u></font>for helpful information about Sarissa and the need for change at Amarin.</div>
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    <div>The General Meeting of Amarin shareholders is scheduled for February 28, 2023, BUT TO MAKE SURE YOUR VOTE COUNTS, <font style="font-weight: bold;"><u>SUBMIT YOUR VOTE ON OR BEFORE TUESDAY, FEBRUARY 21, 2023</u></font>.</div>
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    <div>Shareholders should have received the <font style="font-weight: bold; color: #002060;">BLUE</font><font style="color: #002060;">&#160;</font>proxy card. If you have not received your <font style="font-weight: bold; color: #002060;">BLUE</font><font style="color: #002060;">&#160;</font>proxy card or have any questions on how to vote, please contact:</div>
    <div><br>
    </div>
    <div style="text-align: center;">D.F. King &amp; Co., Inc.</div>
    <div style="text-align: center;">48 Wall Street</div>
    <div style="text-align: center;">New York, New York 10005</div>
    <div style="text-align: center; font-size: 12pt;"><font style="font-weight: bold; font-size: 10pt;">Shareholders call toll-free:</font><font style="font-size: 10pt;"> (800) 331-7024</font></div>
    <div style="text-align: center; font-size: 12pt;"><font style="font-weight: bold; font-size: 10pt;">Banks and Brokers call:</font><font style="font-size: 10pt;"> (212) 269-5550</font></div>
    <div style="text-align: center; font-size: 12pt;"><font style="font-weight: bold; font-size: 10pt;">By Email:</font><font style="font-size: 10pt;">&#160;AMRN@dfking.com</font></div>
    <div><br>
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    <div>* 2022 stock performance calculated from end of day December 31, 2021 &#8211; December 30, 2022. Source: Bloomberg</div>
    <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#8224;</sup> 2021 stock performance calculated from end of day December 31, 2020 &#8211; December 31, 2021. Source: Bloomberg. Chairman Per Wold-Olsen compensation and CEO Karim
      Mikhail calculated based on corporate filings</div>
    <div><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#8225; </sup>Novartis Full Year 2022 Earnings February 1, 2023</div>
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    <div style="font-weight: bold;">Additional Information</div>
    <div><br>
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    <div>Sarissa Capital Management LP (&#8220;Sarissa Capital&#8221;), together with other participants, filed a definitive proxy statement and an accompanying blue proxy card with the SEC on January 31, 2023, in connection with the solicitation of shareholders of
      Amarin Corporation plc (the &#8220;Company&#8221;) at the general meeting of the Company for the election of Sarissa Capital&#8217;s slate of highly-qualified nominees (the &#8220;General Meeting&#8221;). Shareholders are advised to read the definitive proxy statement and other
      relevant documents related to the General Meeting as they contain important information.</div>
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    <div>The definitive proxy statement and other relevant documents are available at no charge on the SEC&#8217;s website at www.sec.gov and at www.freeamarin.com. The definitive proxy statement and other relevant documents are also available at no charge by
      directing a request to Sarissa Capital&#8217;s proxy solicitor, D.F. King &amp; Co., Inc., 48 Wall Street, New York, New York 10005 (Shareholders can call toll-free: (800) 331-7024).</div>
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            <div>Jean Puong<br>
              Sarissa Capital Management LP<br>
              info@sarissacap.com</div>
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