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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common Shares | Treasury Stock | Additional Paid-in Capital | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Treasury Stock, Shares |  |  | (7,486,767) |  |
Balance at Dec. 31, 2021 | $ 667,099 | $ 294,027 | $ (60,726) | $ 1,855,246 | $ (1,421,448)
Balance (in shares) at Dec. 31, 2021 |  | 404,084,775 |  |  |
Issuance of common stock under employee stock purchase plan | 605 | $ 283 |  | 322 |
Issuance of common stock under employee stock purchase plan (in shares) |  | 456,696 |  |  |
Issuance of common stock for milestone payment | 8,203 | $ 3,461 |  | 4,742 |
Issuance of common stock for milestone payment (in shares) |  | 5,817,942 |  |  |
Exercise of stock options | $ 60 | $ 21 |  | 39 |
Exercise of stock options (in shares) | 33,303 | 33,303 |  |  |
Vesting of restricted stock units | $ (1,044) | $ 1,210 | $ (1,044) | (1,210) |
Vesting of restricted stock units (in shares) |  | 1,940,371 | (500,064) |  |
Stock-based compensation | 26,213 |  |  | 26,213 |
Income (loss) for the period | (105,803) |  |  |  | (105,803)
Balance at Dec. 31, 2022 | $ 595,333 | $ 299,002 | $ (61,770) | 1,885,352 | (1,527,251)
Balance (in shares) at Dec. 31, 2022 |  | 412,333,087 |  |  |
Treasury Stock, Shares | 7,986,831 |  | (7,986,831) |  |
Issuance of common stock under employee stock purchase plan | $ 330 | $ 200 |  | 130 |
Issuance of common stock under employee stock purchase plan (in shares) |  | 319,610 |  |  |
Exercise of stock options | $ 1,882 | $ 750 |  | 1,132 |
Exercise of stock options (in shares) | 1,239,763 | 1,239,763 |  |  |
Vesting of restricted stock units | $ (1,982) | $ 2,804 | $ (1,982) | (2,804) |
Vesting of restricted stock units (in shares) |  | 4,248,835 | (1,330,371) |  |
Stock-based compensation | 15,646 |  |  | 15,646 |
Income (loss) for the period | (59,112) |  |  |  | (59,112)
Balance at Dec. 31, 2023 | $ 552,097 | $ 302,756 | $ (63,752) | $ 1,899,456 | $ (1,586,363)
Balance (in shares) at Dec. 31, 2023 |  | 418,141,295 |  |  |
Treasury Stock, Shares | 9,317,202 |  | (9,317,202) |  |

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