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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Shares
Treasury Stock
Additional Paid-in Capital
Accumulated Deficit
Treasury Stock, Shares     (7,486,767)    
Balance at Dec. 31, 2021 $ 667,099 $ 294,027 $ (60,726) $ 1,855,246 $ (1,421,448)
Balance (in shares) at Dec. 31, 2021   404,084,775      
Issuance of common stock under employee stock purchase plan 605 $ 283   322  
Issuance of common stock under employee stock purchase plan (in shares)   456,696      
Issuance of common stock for milestone payment 8,203 $ 3,461   4,742  
Issuance of common stock for milestone payment (in shares)   5,817,942      
Exercise of stock options $ 60 $ 21   39  
Exercise of stock options (in shares) 33,303 33,303      
Vesting of restricted stock units $ (1,044) $ 1,210 $ (1,044) (1,210)  
Vesting of restricted stock units (in shares)   1,940,371 (500,064)    
Stock-based compensation 26,213     26,213  
Income (loss) for the period (105,803)       (105,803)
Balance at Dec. 31, 2022 $ 595,333 $ 299,002 $ (61,770) 1,885,352 (1,527,251)
Balance (in shares) at Dec. 31, 2022   412,333,087      
Treasury Stock, Shares 7,986,831   (7,986,831)    
Issuance of common stock under employee stock purchase plan $ 330 $ 200   130  
Issuance of common stock under employee stock purchase plan (in shares)   319,610      
Exercise of stock options $ 1,882 $ 750   1,132  
Exercise of stock options (in shares) 1,239,763 1,239,763      
Vesting of restricted stock units $ (1,982) $ 2,804 $ (1,982) (2,804)  
Vesting of restricted stock units (in shares)   4,248,835 (1,330,371)    
Stock-based compensation 15,646     15,646  
Income (loss) for the period (59,112)       (59,112)
Balance at Dec. 31, 2023 $ 552,097 $ 302,756 $ (63,752) $ 1,899,456 $ (1,586,363)
Balance (in shares) at Dec. 31, 2023   418,141,295      
Treasury Stock, Shares 9,317,202   (9,317,202)