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Income Taxes - Difference between Benefit from Income Taxes and Amount Computed by Applying Statutory Income Tax Rate to Income Before Taxes (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Income Tax Disclosure [Abstract] |  |  |
Benefits from taxes at statutory rate | $ (19,300) | $ (13,418) | $ (25,952)
Rate differential | 8,896 | 8,042 | 9,141
Change in valuation reserves | 15,769 | 6,415 | 5,083
Nondeductible employee compensation | 1,374 | 31 | 2,344
Stock option/RSU windfall | 783 | 4,500 | 3,569
ISO disqualifying disposition windfall | 459 |  |
Branded prescription drug fee | (280) |  |
Research and development credits | (257) | (376) | (958)
Tax return to provision adjustments | 544 | 4,187 | 424
Foreign exchange | 0 | (2,921) | 7,859
Permanent and other | (1,048) | 141 | (1,542)
Stock Option/RSU Deferred Only Adjustment | (1,716) |  |
Uncertain tax positions | 921 | 780 | (3,290)
Foreign-derived intangible income | (1,162) | (1,939) | (2,935)
Loss of tax attributes |  |  | 8,255
Provision for income taxes | $ 4,983 | $ 5,442 | $ 1,998

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