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Income Taxes - Difference between Benefit from Income Taxes and Amount Computed by Applying Statutory Income Tax Rate to Income Before Taxes (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Income Tax Disclosure [Abstract]
Benefits from taxes at statutory rate	$ (19,300)	$ (13,418)	$ (25,952)
Rate differential	8,896	8,042	9,141
Change in valuation reserves	15,769	6,415	5,083
Nondeductible employee compensation	1,374	31	2,344
Stock option/RSU windfall	783	4,500	3,569
ISO disqualifying disposition windfall	459
Branded prescription drug fee	(280)
Research and development credits	(257)	(376)	(958)
Tax return to provision adjustments	544	4,187	424
Foreign exchange	0	(2,921)	7,859
Permanent and other	(1,048)	141	(1,542)
Stock Option/RSU Deferred Only Adjustment	(1,716)
Uncertain tax positions	921	780	(3,290)
Foreign-derived intangible income	(1,162)	(1,939)	(2,935)
Loss of tax attributes			8,255
Provision for income taxes	$ 4,983	$ 5,442	$ 1,998

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