<SEC-DOCUMENT>0000929638-25-002530.txt : 20250708
<SEC-HEADER>0000929638-25-002530.hdr.sgml : 20250708
<ACCEPTANCE-DATETIME>20250708161056
ACCESSION NUMBER:		0000929638-25-002530
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20250708
FILED AS OF DATE:		20250708
DATE AS OF CHANGE:		20250708

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Grossman William
		CENTRAL INDEX KEY:			0001730229
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41854
		FILM NUMBER:		251111164

	MAIL ADDRESS:	
		STREET 1:		C/O BELLICUM PHARMACEUTICALS, INC.
		STREET 2:		2130 W. HOLCOMBE BLVD., STE. 800
		CITY:			HOUSTON
		STATE:			TX
		ZIP:			77030

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			enGene Holdings Inc.
		CENTRAL INDEX KEY:			0001980845
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			Z4
		FISCAL YEAR END:			1031

	BUSINESS ADDRESS:	
		STREET 1:		4868 RUE LEVY, SUITE 220
		CITY:			SAINT-LAURENT
		STATE:			A8
		ZIP:			H4R 2P1
		BUSINESS PHONE:		(514) 332-4888

	MAIL ADDRESS:	
		STREET 1:		4868 RUE LEVY, SUITE 220
		CITY:			SAINT-LAURENT
		STATE:			A8
		ZIP:			H4R 2P1
</SEC-HEADER>
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<TYPE>3
<SEQUENCE>1
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<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-07-08</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001980845</issuerCik>
        <issuerName>enGene Holdings Inc.</issuerName>
        <issuerTradingSymbol>ENGN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001730229</rptOwnerCik>
            <rptOwnerName>Grossman William</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 4868 RUE LEVY, SUITE 220</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAINT-LAURENT</rptOwnerCity>
            <rptOwnerState>A8</rptOwnerState>
            <rptOwnerZipCode>H4R 2P1</rptOwnerZipCode>
            <rptOwnerStateDescription>QUEBEC, CANADA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Lee Giguere, as attorney-in-fact for the Reporting Person</signatureName>
        <signatureDate>2025-07-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>exhibit24.htm
<TEXT>
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    <title></title>
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    <div style="text-align: center; margin-bottom: 8pt; font-family: 'Times New Roman', serif; font-size: 11pt; font-weight: bold;">LIMITED POWER OF ATTORNEY FOR SECTION 16 REPORTING OBLIGATION</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="text-indent: 36pt; margin-bottom: 8pt; font-family: 'Times New Roman', serif; font-size: 11pt;">I, William Grossman, hereby make, constitute and appoint each of Ronald H.W. Cooper, Ryan Daws or Lee Giguere, as well as any
      person holding the title of Chief Executive Officer, Chief Financial Officer, Secretary or Treasurer of enGene Holdings Inc. (the &#8220;Company&#8221;), as my true and lawful attorney-in-fact to:</div>
    <div style="margin-left: 36pt; margin-bottom: 8pt;"><font style="font-family: 'Times New Roman', serif; font-size: 11pt;">(1)</font><font style="text-indent: 0px; font-size: 5.14pt;" class="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="font-family: 'Times New Roman', serif; font-size: 11pt;"> execute for and on my behalf, in my capacity as a director of the Company, Forms 3, 4, and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules
        thereunder (the &#8220;Exchange Act&#8221;);</font></div>
    <div style="margin-left: 36pt; margin-bottom: 8pt;"><font style="font-family: 'Times New Roman', serif; font-size: 11pt;">(2)</font><font style="text-indent: 0px; font-size: 5.14pt;" class="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="font-family: 'Times New Roman', serif; font-size: 11pt;"> do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Forms 3, 4, or 5, complete and execute any
        amendment(s) thereto, and timely file such form with the United States Securities and Exchange Commission and any stock exchange or similar authority; and</font></div>
    <div style="margin-left: 36pt; margin-bottom: 8pt;"><font style="font-family: 'Times New Roman', serif; font-size: 11pt;">(3)</font><font style="text-indent: 0px; font-size: 5.14pt;" class="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="font-family: 'Times New Roman', serif; font-size: 11pt;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally
        required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such
        attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</font></div>
    <div style="text-indent: 36pt; margin-bottom: 8pt; font-family: 'Times New Roman', serif; font-size: 11pt;">The undersigned hereby grants to such attorney-in-fact full power and authority to do and perform any and every act and thing
      whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or
      revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact&#8217;s substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The
      undersigned acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned, is not assuming, nor is the Company assuming, any of the undersigned&#8217;s responsibilities to comply with Section 16 of the
      Exchange Act.</div>
    <div style="text-indent: 36pt; margin-bottom: 8pt; font-family: 'Times New Roman', serif; font-size: 11pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4,
      and 5 with respect to the undersigned&#8217;s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorney-in-fact.</div>
    <div style="text-indent: 36pt; margin-bottom: 8pt; font-family: 'Times New Roman', serif; font-size: 11pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 8<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> day of July,
      2025.</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman', serif; font-size: 11pt;">By: <u>/s/ William Grossman</u></div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman', serif; font-size: 11pt;">Name: William Grossman</div>
  </div>
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</SEC-DOCUMENT>
