<SEC-DOCUMENT>0000929638-25-002585.txt : 20250714
<SEC-HEADER>0000929638-25-002585.hdr.sgml : 20250714
<ACCEPTANCE-DATETIME>20250714160912
ACCESSION NUMBER:		0000929638-25-002585
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20250708
FILED AS OF DATE:		20250714
DATE AS OF CHANGE:		20250714

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Boyd Matthew Ross
		CENTRAL INDEX KEY:			0002077001
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41854
		FILM NUMBER:		251121825

	MAIL ADDRESS:	
		STREET 1:		164 TELEGRAPH HILL RD
		CITY:			MARSHFIELD
		STATE:			MA
		ZIP:			02050

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			enGene Holdings Inc.
		CENTRAL INDEX KEY:			0001980845
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			Z4
		FISCAL YEAR END:			1031

	BUSINESS ADDRESS:	
		STREET 1:		4868 RUE LEVY, SUITE 220
		CITY:			SAINT-LAURENT
		STATE:			A8
		ZIP:			H4R 2P1
		BUSINESS PHONE:		(514) 332-4888

	MAIL ADDRESS:	
		STREET 1:		4868 RUE LEVY, SUITE 220
		CITY:			SAINT-LAURENT
		STATE:			A8
		ZIP:			H4R 2P1
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-07-08</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001980845</issuerCik>
        <issuerName>enGene Holdings Inc.</issuerName>
        <issuerTradingSymbol>ENGN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002077001</rptOwnerCik>
            <rptOwnerName>Boyd Matthew Ross</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 4868 RUE LEVY, SUITE 220</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAINT-LAURENT</rptOwnerCity>
            <rptOwnerState>A8</rptOwnerState>
            <rptOwnerZipCode>H4R 2P1</rptOwnerZipCode>
            <rptOwnerStateDescription>QUEBEC, CANADA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>Chief Regulatory Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Shares</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7500</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>6.6</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2034-09-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Shares</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>68000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>7.39</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2035-01-29</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Shares</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>51000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Non-qualified stock option grant awarded as an inducement award outside of the Amended and Restated enGene Holdings Inc. 2023 Incentive Equity Plan in accordance with NASDAQ Listing Rule 5635(c)(4). This option vests at 25% on September 16, 2025, which is the first anniversary of the employment commencement date, with the remaining portion to vest monthly over the next three years, subject to the reporting person's continued service.</footnote>
        <footnote id="F2">This option vests in equal monthly installments over forty-eight (48) months on the last day of each month commencing January 29, 2025, subject to the reporting person's continued service.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Lee Giguere, as attorney-in-fact for the Reporting Person</signatureName>
        <signatureDate>2025-07-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>exhibit24.htm
<DESCRIPTION>POWER OF ATTORNEY
<TEXT>
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  <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 24</font><br>
  </div>
  <div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; font-weight: bold;">LIMITED POWER OF ATTORNEY FOR SECTION 16 REPORTING OBLIGATION</div>
    <div>&#160;</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">I, Matthew Ross Boyd, hereby make, constitute and appoint each of Ronald H.W. Cooper, Ryan Daws or Lee Giguere, as well as any person
      holding the title of Chief Executive Officer, Chief Financial Officer, Secretary or Treasurer of enGene Holdings Inc. (the &#8220;Company&#8221;), as my true and lawful attorney-in-fact to:</div>
    <div>&#160;</div>
    <div style="margin-left: 36pt;">(1)<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> &#160;</font>execute for and on my behalf, in my capacity as an officer of the Company, Forms 3,
        4, and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules thereunder (the &#8220;Exchange Act&#8221;);</div>
    <div>&#160;</div>
    <div style="margin-left: 36pt;">(2)<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> &#160;</font>do and perform any and all acts for and on behalf of the undersigned which may be
        necessary or desirable to complete and execute any such Forms 3, 4, or 5, complete and execute any amendment(s) thereto, and timely file such form with the United States Securities and Exchange Commission and any stock exchange or similar
        authority; and</div>
    <div>&#160;</div>
    <div style="margin-left: 36pt;">(3)<font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;"> &#160;</font>take any other action of any type whatsoever in connection with the foregoing
        which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant
        to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">The undersigned hereby grants to such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever
      requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation,
      hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact&#8217;s substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The undersigned
      acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned, is not assuming, nor is the Company assuming, any of the undersigned&#8217;s responsibilities to comply with Section 16 of the Exchange Act.</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with
      respect to the undersigned&#8217;s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorney-in-fact.</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 8<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> day of July, 2025.</div>
    <div>&#160;</div>
    <div>&#160;</div>
    <div style="text-indent: 36pt;">By: <u>/s/ Matthew Ross Boyd</u></div>
    <div style="text-indent: 36pt;">Name: Matthew Ross Boyd</div>
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