Exhibit 16

February 28, 2022

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549-7561

Dear Sirs/Madams:

We have read Item 4.01 of Quad/Graphics, Inc. Form 8-K dated February 24, 2022, and have the following comments:

1.We agree with the statements made in item 4.01(a).

2.We have no basis on which to agree or disagree with the statements made in item 4.01(b).

Yours truly,

/s/ Deloitte & Touche LLP